An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 Mouse
Kishore Chittimalli,
Stephen Adkins,
Sanjay Arora
et al.
Abstract:Background: The APP/PS1 mouse model recapitulates pathology of human Alzheimer’s disease (AD). While amyloid-β peptide deposition and neurodegeneration are features of AD, the pathology may involve inflammation and impaired vascular regeneration. Objective: This study evaluated inflammatory environments in the brain and bone marrow (BM), and the impact on brain microvascular density. Methods: BM and frontal cortex from male nine-month-old APP/PS1 or the control C57Bl6/j mice were studied. Vascular density and … Show more
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