An investigation of the in vivo hydrolysis and absorption of propylene glycol distearate

Long, Calvin L.; Zeitlin, B.R.; Thiessen, R.

doi:10.1016/0003-9861(58)90091-2

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…The biological disposition of 14 C‐labelled propane‐1,2‐diol ester of distearate after oral administration by gavage, was studied in male and female Wistar rats (Long et al., ,b).…”

Section: Assessmentmentioning

confidence: 99%

“…In a second study Long et al (1958b), using the same experimental design investigated the identification of in vivo digestion products, the uptake by the intestinal lymphatics, and the mechanism of transport of propane-1,2-diol ester of distearate (Long et al, 1958b). Chromotographic separation of the radioactivity revealed that after administration of PD*DS hydrolysis products were present in the content of the gastrointestinal tract; however, unhydrolysed PD*DS was also detected.…”

Section: In Vivo Studiesmentioning

confidence: 99%

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Re‐evaluation of propane‐1,2‐diol esters of fatty acids (E 477) as a food additive

Flavourings¹,

Younes²,

Aquilina³

et al. 2018

EFS2

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The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion re-evaluating the safety of propane-1,2-diol esters of fatty acids (E 477) when used as a food additive. The Scientific Committee on Food (SCF) in 1978 endorsed the acceptable daily intake (ADI) of 25 mg/kg body weight (bw) per day, expressed as propane-1,2-diol, established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1974. No adverse effects were observed in short-term studies in rats and dogs at the highest doses tested. The Panel considered that E 477 did not raise a concern for genotoxicity. No chronic toxicity, carcinogenicity, reproductive and developmental toxicity studies with propane-1,2-diol esters of fatty acids were available to the Panel. The Panel considered that any potential adverse effect of propane-1,2-diol ester of fatty acids would be due to propane-1,2-diol, previously re-evaluated as a food additive and for which an ADI of 25 mg/kg bw per day was established. Considering the overall metabolic and toxicity database, the Panel confirmed the previously established ADI for propane-1,2-diol esters of fatty acids (E 477) of 25 mg/kg bw per day expressed as propane 1,2 diol. This corresponds to an ADI for E 477 of 80 mg/kg bw per day, based on the concentration of free and bound propane-1,2-diol amounting to a maximum of 31% as laid down in the EU specification. The Panel concluded that there would not be a safety concern at the reported use levels for E 477 because exposure estimates from the refined non-brand loyal scenario did not exceed the ADI for E 477 in any of the population groups. However, the Panel aims to explore the feasibility of establishing a group ADI for those food additives that result in an exposure to propane-1,2-diol, such as E 477, E 1520 and E 405. Additionally, the Panel will also consider performing a combined exposure assessment to propane-1,2-diol resulting from the use of these food additives. The Panel also recommended some modifications of the EU specifications for E 477.This is an open access article under the terms of the Creative Commons Attribution-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.The EFSA Journal is a publication of the European Food Safety Authority, an agency of the European Union.Re-evaluation of propane-1,2-diol esters of fatty acids (E 477) as a food additive www.efsa.europa.eu/efsajournal 2 EFSA Journal 2018;16(12):5497 SummaryThe Joint FAO/WHO Expert Committee on Food Additives (JECFA) evaluated propane-1,2-diol esters of fatty acids in 1974 and stated that there is evidence for hydrolysis of propane-1,2-diol esters of fatty acids resulting in the products propane-1,2-diol, for which an acceptable daily intake (ADI) of 25 mg/kg body weight (bw) per day has previously established, and fatty acids. JECFA established an ADI of 25 mg/kg bw per day for propane-1,2-diol esters of fatty acids, this ADI was expressed as propane-1,2-dio...

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“…The biological disposition of 14 C‐labelled propane‐1,2‐diol ester of distearate after oral administration by gavage, was studied in male and female Wistar rats (Long et al., ,b).…”

Section: Assessmentmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%