An investigation of the effectiveness against bacteriuria of silver-coated catheters in short-term urinary catheter applications: A randomized controlled study

Akçam, Füsun Zeynep; Kaya, Onur; Temel, Esra Nurlu; Büyüktuna, Seyit Ali; Ünal, Onur; Yürekli, Vedat Ali

doi:10.1016/j.jiac.2019.04.004

Cited by 7 publications

(12 citation statements)

References 18 publications

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“…Data of bacteriuria (till the last follow-up) was pooled for a meta-analysis based on the type of noble metal coating (Fig 2). Seven studies [11,12,27,28,30,31,34] with eight reports were pooled for silver alloy catheter vs standard catheter. Results indicated a significant decrease in the risk of bacteriuria with silver alloy-coated catheters (RR 0.63, 95%CI 0.44-0.90, P = 0.01; I 2 = 72%).…”

Section: Discussionmentioning

confidence: 99%

“…The results were still significant for silver-alloy catheters (RR 0.46, 95%CI 0.26-0.81, P = 0.007; I 2 = 63%) when used for a catheterization period of <1week (Fig 4). A total of three trials [11,12,30,31] with four reports were pooled for the incidence of bacteriuria after >1week of indwelling silver alloy catheter vs standard catheter. Our results indicated significant difference between the two groups (RR 0.71, 95%CI 0.55-0.92, P = 0.01; I 2 = 0%) (Fig 4).…”

Section: Discussionmentioning

confidence: 99%

“…Three employed silver-oxide catheters [19,21,22], two studies were only in abstract form [20,23], two studied the effects of long-term catheterization [25,26] while one study compared two different types of silver-coated catheters [24]. A total of 13 studies were included in the review [10][11][12][13][14][15][27][28][29][30][31][32][33]. Details of the included studies are presented in Table 1.…”

Section: Plos Onementioning

confidence: 99%

“…For the comparative arm, studies described the catheters as standard/regular catheter, standard silicone catheter, standard latex catheter, standard silicone latex catheter, polytetrafluoroethylene (PTFE) coated latex catheter, teflonised latex catheter, standard hydrogel coated catheter and standard hydrogel-coated latex catheter. The mean, median or total duration of catheterization was �14 days for all studies except one study where catheterization was done up to 22 days [12]. However, the authors reported outcomes of bacteriuria at frequent intervals from 2-22 days.…”

Section: Plos Onementioning

confidence: 99%

“…In a Cochrane review by Lam et al, the authors had evaluated evidence on the efficacy of such noble-metal coated catheters in 2014 [8]. Since then many new trials have been published and there is a need for updated evidence on this subject, to provide guidelines to health-care providers [12][13][14][15]. Hence, the primary objective of this review was to perform a systematic literature search and conduct a meta-analysis to answer the clinical question: Does the use of noble-metal coated urinary catheters for short-term catheterization of adults reduce the incidence of CAUTI?…”

Section: Introductionmentioning

confidence: 99%

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Role of noble metal-coated catheters for short-term urinary catheterization of adults: a meta-analysis

2020

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Objective To evaluate the efficacy of noble-metal coated catheters in reducing catheter-associated urinary tract infections (CAUTI) in adult patients requiring short term catheterization. Methods An electronic literature search of PubMed, BioMed Central, Embase, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials) and Google scholar was carried out from inception to 10th October 2019. Any prospective study or randomized controlled trial (RCT) on adult patients comparing noble-metal coated urinary catheters with any standard catheter and evaluating the incidence of CAUTI or bacteriuria was included. Results A total of 13 studies were included in the systematic review. 12 were RCTs and one was a prospective cross-over trial. Catheters employed in the study group were grouped into two subgroups: Silver alloy coated or Noble metal alloy-coated (Gold, Silver, and Palladium) catheters. Bacteriuria was the most commonly studied outcome variable across trials. Metaanalysis indicated that silver alloy-coated catheters (RR 0.63, 95%CI 0.44-0.90, P = 0.01; I2 = 72%) and noble metal alloy catheters (RR 0.58, 95%CI 0.41-0.81, P = 0.001; I2 = 0%) significantly reduce the risk of bacteriuria. Subgroup analysis based on the duration of catheterization demonstrated that silver alloy catheters reduce the risk of bacteriuria with >1week of catheterization (RR 0.46, 95%CI 0.26-0.81, P = 0.007; I2 = 63%). Symptomatic CAUTI was evaluated only in four studies with variable results. The quality of the included studies was not high. Conclusions Our review indicates that bacteriuria may be reduced with the use of noble metal-coated catheters during short-term catheterization of adults, however, the quality of evidence is not

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of noble metal-coated catheters for short-term urinary catheterization of adults: a meta-analysis

2020

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Use of Antimicrobial-Coated Catheters in Preventing Catheter-Associated Urinary Tract Infections and Bacteriuria: A Meta-Analysis for Clinicians

et al. 2021

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Introduction:Catheter-associated urinary tract infections comprise a significant burden to the health care system and are of major concern for indwelling catheter use. Catheter coatings have been studied for their potential to reduce risk of infection. The purpose of this meta-analysis is to determine the efficacy of coated catheters across clinical studies in preventing these common nosocomial infections.Methods:Searches were conducted on PubMed Central® and ScienceDirect using the terms “catheter,” “urinary tract infection” and “coated” or “antimicrobial.” Articles included were prospective randomized clinical studies of coated (experimental) vs uncoated (control) catheters published in English between the years 2000 and 2020. Results from included studies were analyzed using Fisher’s exact test and conditional logistic regression.Results:Fifteen studies met the inclusion criteria. Tested urinary catheter coatings include silver, silver salt, nitrofurazone and metal-alloy. Conditional logistic regression (p <0.001) shows statistically significant negative association between coated catheter use and the incidence of catheter-associated urinary tract infections. The odds ratio of 0.80 and 95% confidence interval (0.74, 0.88) support protective effect of catheter coatings.Conclusions:Meta-analysis demonstrates a negative association of coated catheter and incidence of catheter-associated urinary tract infections, supporting that antimicrobial catheter coatings decreases incidence of infection across studies. Further clinical research is recommended to determine the potential for catheter coating adoption in clinical practice to reduce catheter-associated urinary tract infection risk and incidence.

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A comparative study of experimental urinary catheters containing silver and zinc for biofilm inhibition

Vaitkus¹,

Simoes-Torigoe²,

Wong³

et al. 2021

J Biomater Appl

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Both commercial and experimental antibacterial urinary catheters were investigated for their efficacy in preventing planktonic growth and biofilm formation of Escherichia Coli bacteria in a synthetic urine solution. Experimental antibacterial catheters having thin (<500 µm) dispersions of Ag, Ag/Ag2O, or Zn/Ag2O in polydimethylsiloxane (PDMS) binder all exhibited significant antimicrobial activity, outperforming traditional commercial antibacterial catheters. All experimental catheters prevented planktonic growth of bacteria and did not exhibit biofilm formation during a six-day test period using a colony forming unit (CFU) measurement method. On the other hand, the best performing commercial catheters demonstrated efficacy for only 3 days in planktonic growth tests and formed multiple bacterial colonies in CFU measurements. The Zn/Ag2O/PDMS experimental catheter was the only catheter observed to produce hydrogen peroxide, a reactive oxygen species known to inhibit biofilm formation; lack of detectable hydrogen peroxide production by the Ag2O/PDMS and Ag/Ag2O/PDMS experimental catheters suggests that bactericidal action most likely arises from release of silver ions present in the PDMS coatings.

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An investigation of the effectiveness against bacteriuria of silver-coated catheters in short-term urinary catheter applications: A randomized controlled study

Cited by 7 publications

References 18 publications

Role of noble metal-coated catheters for short-term urinary catheterization of adults: a meta-analysis

Role of noble metal-coated catheters for short-term urinary catheterization of adults: a meta-analysis

Use of Antimicrobial-Coated Catheters in Preventing Catheter-Associated Urinary Tract Infections and Bacteriuria: A Meta-Analysis for Clinicians

A comparative study of experimental urinary catheters containing silver and zinc for biofilm inhibition

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