An investigation of the association between the level of prolactin in serum and type II diabetes

Manshaei, Najmeh; Shakibaei, Feloria; Fazilati, Mohammad; Salavati, Hossein; Negahdary, Masoud; Palizban, Abbasali

doi:10.1016/j.dsx.2018.07.007

Cited by 14 publications

(8 citation statements)

References 41 publications

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“…A 22-year follow-up study in the United States studying serum PRL in women revealed that high levels of PRL reduce the risk of incident T2DM ((HR: 0.73 (0.55-0.95)) [ 10 ]. This finding was also consistent with another case-control study by Manshaei et al, which reported markedly lower serum PRL levels in females with T2DM than in healthy volunteers (5.32 ± 0.36 vs. 18.38 ± 2.3 ng/dl) [ 11 ]. The stronger association in females may be attributed to relatively higher serum PRL levels than males and a protective effect of estrogen on β-cells via anti-inflammatory effects and insulin sensitivity [ 12 ].…”

Section: Discussionsupporting

confidence: 92%

Association of Serum Prolactin With Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study From South India

Jayashankar¹,

Manohar²,

Joshi³

et al. 2022

Cureus

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Background: The association of serum prolactin (PRL) with diabetes is still uncertain, with a paucity of data in the south Indian population. This study aims to compare the serum PRL levels between type 2 diabetes mellitus (T2DM) patients and normoglycaemic volunteers and correlate the serum PRL level with fasting plasma glucose (FPG), postprandial plasma glucose (PPG), glycated haemoglobin (HbA1c) levels, and the lipid profile in the study population. Methods: This was a comparative cross-sectional study among 112 T2DM participants and 112 healthy volunteers in a tertiary care centre in India. All participants were tested for FPG, PPG, HbA1c, fasting serum lipid profile, and serum PRL, which were compared between T2DM patients and healthy volunteers. Results: The serum PRL in T2DM patients was significantly lower compared to healthy volunteers (8.67 ± 4.37 vs. 13.76 ± 6.55 ng/ml, P < 0.001). FPG, PPG, and HbA1c correlated inversely with serum PRL in our study population. On multivariable logistic regression adjusted for age and sex, a higher serum PRL level within the physiological range was protective for T2DM (adjusted odds ratio: 0.83, 95% CI: 0.77-0.90, P < 0.001). Serum PRL levels were inversely correlated with serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides, but not with high-density lipoprotein cholesterol. Conclusions: A high serum PRL within the physiological range was inversely associated with the prevalence of T2DM in the south Indian population. Serum PRL also correlated inversely with glycaemic and blood lipid parameters. Larger longitudinal studies are required to further validate the association of serum PRL with various components of metabolic syndrome in the south Indian population.

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Section: Discussionsupporting

confidence: 92%

Association of Serum Prolactin With Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study From South India

Jayashankar¹,

Manohar²,

Joshi³

et al. 2022

Cureus

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“…Though it is clear that high prolactin levels are metabolically unfavorable, multiple studies have also shown low prolactin levels to be associated with increased metabolic disease (107)(108)(109). For example, Manshaei et al found that prolactin levels in diabetic patients were significantly lower (5.32 ± 0.36 ng/ mL) when compared to healthy controls (18.38 ± 2.3 ng/mL) (109). There may be a "goldilocks zone" for serum prolactin that promotes metabolic homeostasis, though exact ranges are variable amongst studies (1,110,111).…”

Section: Prolactin: a "Goldilocks Zone"mentioning

confidence: 99%

Metabolic effects of prolactin and the role of dopamine agonists: A review

et al. 2022

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Prolactin is a polypeptide hormone that is well known for its role in reproductive physiology. Recent studies highlight its role in neurohormonal appetite regulation and metabolism. Elevated prolactin levels are widely associated with worsening metabolic disease, but it appears that low prolactin levels could also be metabolically unfavorable. This review discusses the pathophysiology of prolactin related metabolic changes, and the less commonly recognized effects of prolactin on adipose tissue, pancreas, liver, and small bowel. Furthermore, the effect of dopamine agonists on the metabolic profiles of patients with hyperprolactinemia are discussed as well.

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“…Так как средние значения и показатели медианы ПРЛ и ТТГ сопоставимы в возрастных группах 25- [20,21]. Эти исследования были расширены и подтверждены в разных популяциях [22][23][24][25]. В третьем исследовании участвовали дети (средний возраст 10,7 года), и было обнаружено, что низкие уровни ПРЛ имели место при ожирении и были фактором риска для развития МС независимо от других факторов [26].…”

Section: обсуждение основного результата исследованияunclassified

“…В немногочисленных работах показано, что «более высокие» (в пределах и выше физиологического диапазона 25 мкг/л, или 525 мЕД/л) уровни ПРЛ способствуют благоприятному метаболическому гомеостазу при диабете и метаболических изменениях, вызванных ожирением [7]. В разные годы в ряде клинических и экспериментальных работ было показано, что низкие уровни ПРЛ связаны с неблагоприятным метаболическим профилем [8][9][10]. Нужно отметить, что метаболические последствия низконормальных значений и гиперпролактинемии у женщин молодого возраста в большей степени мало изучены.…”

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The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

et al. 2021

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Background: Hyperprolactinemia is one of the most common hypothalamic-pituitary-endocrine disorders in women of reproductive age, with the highest frequency at the age of 25–44 years. In addition to influencing the reproductive system, it is important to study the effects of prolactin (PRL) on various metabolic links. Available data indicate that the effect of PRL on metabolism depends on its level. In this regard, the study of the relationship of different levels of PRL with anthropometric parameters, indicators of lipid and carbohydrate metabolism in young women is relevant.Aim: To study the frequency of metabolic syndrome (MS) and its individual components in women aged 25–45 years with different levels of prolactin.Materials and methods: Work design — cross-sectional research. A randompopulationsample of women 25–45 agedwas examined. Pregnant and breastfeeding women with macroprolactinoma, and taking antipsychotics were excluded. Information was collected using a structured questionnaire, including, but not limited to, the presence of pregnancies, childbirth, menstrual irregularities, and a clinical examination, anthropometric measurements, biochemical and hormonal blood analyzes were performed. Statistical data processing was carried out.Results: According to the inclusion and exclusion criteria, this analysis presents data from 401 women, the average age of the examibed was 36.14±6.19 years. There was no difference in the levels of thyroid-stimulating hormone and prolactin (PRL) in the age groups of 25–34 and 35–45 years. According to the survey, the incidence of thyroid diseases in the studied groups is comparable. Every fifth woman indicated menstrual irregularities. Among women 25–45 years old, women with low-normal PRL values (Me = 4.49 [3.52; 5.41] ng/ml) have more unfavorable metabolic indicators. Metabolic syndrome (MS) was detected in 28%,with a predominant increase in the frequency of abdominal obesity — 55%, hypercholesterolemic LDL — 63%. Women with high PRL (Me = 41.35 [34.78; 45.88] ng / ml) also have an unfavorable metabolic profile: MS was detected in 47%, abdominal obesity — 56%, hypertension — 39%.Conclusions: In women 25–45 years old, low and high PRL values are more often associated with metabolic ill health. PRL values are from 7.8 to 28 ng / ml, i.e. conditionally defined as normal, highly normal and at the level of moderate hyperprolactinemia contribute to the maintenance of a favorable metabolic profile. When deciding on the treatment of women with non-tumor etiology hyperprolactinemia, it is important to assess the metabolic status, expanding their understanding of PRL as a hormone associated only with lactation and with the pituitary-gonad axis.

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An investigation of the association between the level of prolactin in serum and type II diabetes

Cited by 14 publications

References 41 publications

Association of Serum Prolactin With Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study From South India

Association of Serum Prolactin With Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study From South India

Metabolic effects of prolactin and the role of dopamine agonists: A review

The frequency of metabolic syndrome and its individual components in women aged 25–45 years, depending on the level of prolactin

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