An investigation of relationships between hypoxia-inducible factor-1α gene polymorphisms and ovarian, cervical and endometrial cancers

Konac, Ece; Onen, Hacer Ilke; Metindir, Jale; Alp, Ebru; Bırı, Aydan; Ekmekçi, Abdullah

doi:10.1016/j.cdp.2007.01.001

Cited by 52 publications

(47 citation statements)

References 25 publications

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“…In our study we did not found any association of c.C111A polymorphism with breast cancer risk as variant allele was completely absent in patients and only 0.5% of the controls carried the A allele. Similar to our findings, A allele was not previously observed in breast (Apaydin et al, 2008) and ovarian, cervical and endometrial cancer (Konac et al, 2007). However, Naidu et al observed a very low frequency of A allele in both breast cancer patients and controls (0.4 vs 0.2%) in Malaysian population (Naidu et al, 2009).…”

Section: Discussionsupporting

confidence: 90%

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

Sharma¹,

Kapahi²,

Sambyal³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

Sharma¹,

Kapahi²,

Sambyal³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Overall,26 relevant studies involving 6337 cases and 9302 controls were selected in this metaanalysis [21,26,27,29,30,32,[43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62]. The main characteristics of these studies were shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Genotype and allele distributions of 1790G/A polymorphism among cancer cases and controls and P value of HWE in controls were shown in Table 1 and 2. All studies were case-control studies, including three oral squamous cell carcinoma (OSCC) studies [46,51,59], three prostate cancer studies [29,44,60], three renal cell carcinoma studies [21,49,57], three breast cancer studies [30,32,50], two gynecologic carcinoma studies [27,53], two colorectal studies [26,62], two pancreatic cancer studies [55,58], three lung cancer studies [47,54,56] and the others(including head and neck squamous cell carcinoma(HNSCC) [43], transitional cell carcinoma of the bladder [45], hepatocellular carcinoma [52], gastric cancer [52], glottic cancer [61]). Cancers were histological or pathological in most studies.…”

Section: Resultsmentioning

confidence: 99%

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Update meta-analysis on 1790G/A polymorphism and cancer risk: Evidence from 26 studies

Liu¹,

Shi²,

Yang³

et al. 2014

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The results from the published studies on the association between hypoxia-inducible factor-1(Hif-1/HIF-1) polymorphisms and cancer risk are conflicting. The common 1790G/A rs11549467) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between 1790G/A (rs11549467) and cancer risk remains inconclusive.To better understand the role of 1790G/A (rs11549467) polymorphism in cancer, we conducted this comprehensive metaanalysis encompassing 6337 cases and 9302 controls.Overall, the 1790G/A (rs11549467) genetic polymorphism was associated with higher cancer risk. In the stratified analysis, significant associations were found between the Hif-1/HIF-1 1790G/A polymorphism and lung cancer, pancreatic cancer and oral squamous cell carcinoma. We also observed that the AA genotype might modulate lung cancer (OR=5. (AA vs. GG) and recessive genetic model (AA vs. AG/GG) among Caucasian population. When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC). The phenomenon also indicates that the SNP functions as a recessive mutation needs to be verified or linked with functional studies.

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“…Semenza et al (2013) have confirmed that if the function of HIF-1A is changed by mutations, the tissue became vulnerable to hypoxia which may correlate with tumor invasion and metastasis, and thereby the genetic polymorphisms of HIF-1A may have an impact on the incidence of cancers. Several subsequent studies have indicated that common genetic polymorphisms in HIF-1A gene is involved in pre-malignant phases and developmental steps of breast cancer, renal cell carcinoma, prostate cancer, and cervical cancer (Ling et al, 2005;Konac et al, 2007;Kim et al, 2008;Foley et al, 2009). Recently, a growing number of evidences have shown that HIF-1A gene mutations might play important roles in the development of digestive tract cancers (Cummins et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies

Xu¹,

Xu²,

Li³

et al. 2014

Genet. Mol. Res.

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ABSTRACT.Many existing studies have demonstrated that common polymorphisms in the hypoxia inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a precise estimation of the relationships between HIF1A Pro582Ser polymorphism and the risk of digestive tract cancers. We searched CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through May 1, 2013. Meta-analysis was performed using the STATA 12.0 software. We assessed 6 case-control studies that included a total of 911 digestive tract cancer patients and 2774 healthy controls. Our meta-analysis indicated that HIF1A Pro582Ser polymorphism was associated with an increased risk of digestive tract cancer. Subgroup analysis by ethnicity suggested that HIF1A Pro582Ser polymorphism might increase an individual's susceptibility to digestive tract cancer in Asian populations. However, similar association was not observed in Caucasian populations. In conclusion, our findings suggest that HIF1A Pro582Ser polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.

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An investigation of relationships between hypoxia-inducible factor-1α gene polymorphisms and ovarian, cervical and endometrial cancers

Cited by 52 publications

References 25 publications

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

Update meta-analysis on 1790G/A polymorphism and cancer risk: Evidence from 26 studies

HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies

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