An investigation of potential sources of artifacts in SPECT-CT myocardial perfusion studies

Celler, Anna; Shcherbinin, Sergey; Hughes, Tyler

doi:10.1007/s12350-009-9171-0

Cited by 14 publications

(7 citation statements)

References 16 publications

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“…This means that in patients with a high BMI, quantifying smaller lesions will be more challenging. Using more iterations in the reconstruction of images of larger patients might improve convergence and thereby improve resolution and prevent artifacts, which was also shown for SPECT/CT myocardial perfusion studies by Celler et al [46]. The effect of increased attenuation could be canceled by an increase in scan time per projection or by increasing patient dose.…”

Section: Discussionmentioning

confidence: 74%

Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study

et al. 2019

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Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many factors. Using phantom measurements, this multi-vendor and multi-center study evaluates the quantitative accuracy and inter-system variability of various SPECT/CT systems as well as the effect of patient size, processing software and reconstruction algorithms on recovery coefficients (RC). Methods: Five SPECT/CT systems were included: Discovery™ NM/CT 670 Pro (GE Healthcare), Precedence™ 6 (Philips Healthcare), Symbia Intevo™, and Symbia™ T16 (twice) (Siemens Healthineers). Three phantoms were used based on the NEMA IEC body phantom without lung insert simulating body mass indexes (BMI) of 25, 28, and 47 kg/m 2. Six spheres (0.5-26.5 mL) and background were filled with 0.1 and 0.01 MBq/mL 99m Tc-pertechnetate, respectively. Volumes of interest (VOI) of spheres were obtained by a region growing technique using a 50% threshold of the maximum voxel value corrected for background activity. RC, defined as imaged activity concentration divided by actual activity concentration, were determined for maximum (RC max) and mean voxel value (RC mean) in the VOI for each sphere diameter. Inter-system variability was expressed as median absolute deviation (MAD) of RC. Acquisition settings were standardized. Images were reconstructed using vendor-specific 3D iterative reconstruction algorithms with institute-specific settings used in clinical practice and processed using a standardized, in-house developed processing tool based on the SimpleITK framework. Additionally, all data were reconstructed with a vendor-neutral reconstruction algorithm (Hybrid Recon™; Hermes Medical Solutions). Results: RC decreased with decreasing sphere diameter for each system. Intersystem variability (MAD) was 16 and 17% for RC mean and RC max , respectively. Standardized reconstruction decreased this variability to 4 and 5%. High BMI hampers quantification of small lesions (< 10 ml). Conclusion: Absolute SPECT quantification in a multi-center and multi-vendor setting is feasible, especially when reconstruction protocols are standardized, paving the way for a standard for absolute quantitative SPECT.

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Section: Discussionmentioning

confidence: 74%

Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study

et al. 2019

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“…This is probably due to the effect of subdiaphragmatic activity and diaphragmatic attenuation especially in the case of inferior wall which is not corrected in FBP reconstruction. This finding may suggest that, although the compensation techniques for the photon attenuation and scatter might be effective with Flash 3D, it does not decrease the difficulties associated with the inferior wall attenuation artifacts [16]. Also, a certain degree of misregistration might be present between SPECT and CT data, even after manual realignment.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Comparison of Myocardial Perfusion Defects using Different Reconstruction Algorithms

Naum¹,

Kleven-Madsen²

2012

J Clinic Experiment Cardiol

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Objective: To investigate the impact of a reconstruction method incorporating corrections for scatter, attenuation, and distance dependent detector response on cardiac single emission computed tomography (SPECT) perfusion studies compared with filtered back projection (FBP). Materials and methods: A total of 20 patients underwent same-day, rest-stress SPECT/CT myocardial perfusion imaging. Images were reconstructed using iterative 3D ordered-subsets expectation-maximization (OSEM 3D) and FBP algorithms. Stress and rest myocardial perfusion defects were quantified using polar maps and normal database comparisons. The Bland-Altman plots were used to assess their degree of agreement. Results were confirmed by coronary angiography. The contrast, contrast to noise ratio and signal to noise ratio were used for the quantitative evaluation of the reconstruction quality. Results: Perfusion defect extent quantification on OSEM 3D reconstructed images agreed and correlated well with defect extent quantification on FBP reconstructed images (bias ± standard deviation,-15% ± 20; r = 0.63) during stress and at rest (-10% ±15; r=0.70). Agreement and correlation were similar for severity scores during stress (-1.02 ± 1.77 SD's; r=0.62), and at rest (-1.10 ± 1.49 SD's; r=0.61). There were no statistically significant differences between the methods regarding perfusion defect extent or severity. The overall agreement rate with coronary angiography was similar. OSEM 3D reconstruction algorithm significantly increases the image contrast by 31% (P<0.05). Conclusions: Compensation for detector response, attenuation and scatter improves image contrast compared with FBP. Applying quantitative analysis, OSEM 3D reconstruction produced increased image contrast compared to FBP, but similar results regarding the size and severity of left ventricular perfusion defects.

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“…However, results may vary, and CT-AC may improve specificity but decrease sensitivity, limiting improvement in the diagnostic accuracy of MPI [12,13]. Further, CT-AC may show false-positive defects [14]. Therefore, the utility of CT-AC in routine clinical practice is controversial.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography attenuation correction improves the risk stratification accuracy of myocardial perfusion imaging

Jiang²,

Huang³

et al. 2013

Nuclear Medicine Communications

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An investigation of potential sources of artifacts in SPECT-CT myocardial perfusion studies

Abstract: In situations with strong and non-uniform attenuation, the reconstruction methods with sophisticated data processing (large matrix size, AC + RR corrections) may require substantially more processing than is currently used and/or recommended.

Cited by 14 publications

References 16 publications

Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study

Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study

Quantitative Comparison of Myocardial Perfusion Defects using Different Reconstruction Algorithms

Computed tomography attenuation correction improves the risk stratification accuracy of myocardial perfusion imaging

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