An Investigation of Lesion Detection Accuracy for Artificial Intelligence–Based Denoising of Low-Dose64Cu-DOTATATE PET Imaging in Patients with Neuroendocrine Neoplasms
Abstract:Frequent somatostatin receptor PET, for example, 64 Cu-DOTATATE PET, is part of the diagnostic work-up of patients with neuroendocrine neoplasms (NENs), resulting in high accumulated radiation doses. Scanrelated radiation exposure should be minimized in accordance with the as-low-as-reasonably achievable principle, for example, by reducing injected radiotracer activity. Previous investigations found that reducing 64 Cu-DOTATATE activity to below 50 MBq results in inadequate image quality and lesion detection.… Show more
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