An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides

Nuclear blebbing of biologically active organoselenium compound towards human cervical cancer cell (HeLa): In vitro DNA/HSA binding, cleavage and cell imaging studies

“…A C C E P T E D ACCEPTED MANUSCRIPT 4 compound 1 was based on our understanding of a series of diselenides synthesized by our group, wherein we found that the molecule having bistrifluoromethyl phenyl moiety displayed most potent anticancer activity [12]. With this rationale, in vitro DNA binding profile of organoselenium compound 1 with CT-DNA and cleavage studies of 1 with pBR322 plasmid DNA by agarose gel electrophoresis was evaluated.…”

Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair

“…1–4 Unfortunately, polyamides can be limited by synthetic costs, aggregation and cell-uptake problems. 5,6 In an interesting contrast, relatively simple AT sequence selective minor-groove binders have had good success in therapeutic targeting of DNA in cells ranging from various types of cancers 7–13 to bacteria 14–16 and parasitic microorganisms. 17–22 DNA minor-groove binding heterocyclic diamidines, such as pentamidine and berenil, are examples with a long history of therapeutic use.…”

Cyanuric‐Chloride‐Mediated Synthesis of 2‐Aryl‐3‐tert‐butoxycarbonyl‐thiazolidine‐4‐carboxylic Acid Anilides: Mechanistic, X‐Ray Crystal Structures and Cytotoxicity Studies

“…All the synthesized anilides were initially evaluated for their selective anticancer activity towards a panel of seven different human cancer cell lines as A549 (Adenocarcinomic human alveolar basal epithelial cells), MIA PaCa (Human pancreatic carcinoma cells), PC3 (Human prostate cancer cell line), HCT116 (Human colon cancer cell line), SW620 (Metastatic Colon carcinoma cell lines), MCF‐7 (Human breast cancer cell line), MDA MB 231(Human breast cancer cell lines). The cytotoxicity profile of the synthesized compounds was evaluated through the % cell viability test by using the well‐known in vitro cell proliferation MTT assay . The % cell viability test of the synthesized compounds at an uniform concentration of 50 μM was performed using Doxorubicin (DOX) as a standard and the results for the three series are demonstrated in Table S1 (supporting information) and depicted in Figure –.…”