An investigation of how fungal infection influences drug penetration through onychomycosis patient’s nail plates

McAuley, William J.; Jones, Stuart A.; Traynor, Matthew J.; Guesné, S.; Murdan, Sudaxshina; Brown, Marc

doi:10.1016/j.ejpb.2016.03.008

Cited by 41 publications

(45 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,7,8 The structure of the nail plate prevents effective ungual treatment of nail disorders because active agents cannot permeate through nail plates. [9][10][11][12][13] In order to deliver a sufficient amount of active agent into and through the nail plate, the permeability of the nail plate to the drug needs to be enhanced. Nail disorders can be treated with topical or oral therapies.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Caffeine Loaded Liposome and Ethosome Formulations for Transungual Application

Tanrıverdi

2018

tjps

View full text Add to dashboard Cite

Amaç: Bu tasarım çalışması "International Conference on Harmonization" rehberleri kapsamındaki tasarımda kalite yaklaşımı çerçevesinde uygulanmıştır. Yapay sinir ağları (ANN) kullanılarak ketiapin fumaratın değiştirilmiş salımlı tablet formülasyonunun kalitesi değerlendirilmiş ve referans ürüne benzer olan yeni bir formülasyon tespit edilmiştir. Gereç ve Yöntemler: On iki farklı formül üretilmiş ve test edilmiştir. Referans ürünün analiz sonuçları ve deneysel sonuçlarımız çıktı olarak Intelligensys Ltd. şirketine ait programlarında ANN'nin eğitimi için kullanılmıştır. Bulgular: INForm V.4 ANN programı tarafından önerilen yeni bir formülasyon (F13) ile gastrointestinal sistemdeki üç farklı pH da çözünme testleri yapılmıştır. Bu formülasyonun uygunluğu da f2 benzerlik testi sonuçları karşılaştırılarak doğrulanmıştır. Sonuç: Bu programların kullanılması, çoklu değerlendirme yöntemleri ve daha düşük maliyetle Ar-Ge süreçlerini desteklemekte ve alternatif formülasyonlar daha hızlı tespit edilebilmektedir. Anahtar kelimeler: Ketiapin fumarat, tasarımda kalite, yapay sinir ağları, bulanık mantık, uzatılmış salım tabletler, yaş granülasyon Objectives: This design study was implemented within the scope of the quality by design approach, which included the "International Conference on Harmonization" guidelines. We evaluated the quality of a modified-release tablet formulation of quetiapine fumarate, which was designed using artificial neural networks (ANN), and determined a new formulation that was similar to the reference product. Materials and Methods: Twelve different formulations were produced and tested. The reference product's results and our experimental results were used as outputs for the training of the ANN programs of Intelligensys Ltd. Results: Dissolution tests were performed with the new formulation (F13) suggested by the INForm V.4 ANN program in three different pHs of the gastrointestinal system. The compliance of this formulation was confirmed by comparing the results with an f2 similarity test. Conclusion: Use of these programs supports research and development processes with multiple evaluation methods and alternative formulations may be determined faster and at lower cost.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Caffeine Loaded Liposome and Ethosome Formulations for Transungual Application

Tanrıverdi

2018

tjps

View full text Add to dashboard Cite

show abstract

“…Topical application of these drugs minimizes the potential for drug–drug interactions, acute liver injury, and systemic toxicity, so there is less concern when using topical antifungal agents in children, although in adults, the cure rate is inferior to that of systemic agents. Efinaconazole and tavaborole, used off‐label, could be practical alternatives to oral antifungals for the treatment of children with mild to moderate onychomycosis, and possibly even severe onychomycosis, because of their potent action against dermatophytes and their tolerability . They may also offer a broader spectrum of activity than terbinafine.…”

Section: Discussionmentioning

confidence: 99%

“…Efinaconazole and tavaborole, used off-label, could be practical alternatives to oral antifungals for the treatment of children with mild to moderate onychomycosis, and possibly even severe onychomycosis, because of their potent action against dermatophytes and their tolerability. [29][30][31][32][33] They may also offer a broader spectrum of activity than terbinafine.…”

Section: Discussionmentioning

confidence: 99%

Onychomycosis in children: Safety and efficacy of antifungal agents

Gupta

Mays

Versteeg

et al. 2018

Pediatric Dermatology

View full text Add to dashboard Cite

Onychomycosis is an uncommon condition in childhood, but prevalence in children is increasing worldwide.The objective was to review the efficacy and safety of systemic and topical antifungal agents to treat onychomycosis in children. Databases (Pubmed, OVID, Scopus, clinicaltrials.gov, Cochrane Library) were searched. Seven studies were selected for inclusion. Only one was a randomized controlled trial. In total, 208 children were administered antifungal agents for the treatment of onychomycosis. Four reports of mild adverse events were documented (1.9% of treated children), one of which discontinued treatment (0.5%). Limitations of this review are the lack of randomized controlled trials available in pediatric onychomycosis. These findings suggest that antifungal therapies used to treat onychomycosis in children are associated with a low incidence of adverse events. Current dosing regimens for antifungal drugs are effective and appear safe to use in children, notwithstanding that the Food and Drug Administration has not approved any of these agents for the treatment of onychomycosis in children. To our knowledge, this review is the most up-to-date, comprehensive summary of pediatric onychomycosis treatment.

show abstract

“…Prescribing antifungal therapy for suspected, but not confirmed nail fungus is therefore not recommended, and fungal confirmation or exclusion is an important initial step to ensure that patients are correctly treated. However, whether a nail has onychomycosis, or onychodystrophy due to other causes, barrier function and structural integrity are compromised in diseased nails, 5,6 and should be addressed. If fungus is indeed confirmed, oral and topical antifungal options are available.…”

Section: Methodsmentioning

confidence: 99%

“…Future clinical studies of poly-ureaurethane 16% in combination with oral or topical antifungals are of course necessary to determine both in vivo efficacy and the validity of these assumptions. However, whether a nail has onychomycosis, or onychodystrophy due to other causes, barrier function and structural integrity are compromised in diseased nails, 5,6 and should be addressed.…”

Section: Fpomentioning

confidence: 99%

Efinaconazole 10% and Tavaborole 5% Penetrate Across Poly-ureaurethane 16%: Results of In Vitro Release Testing and Clinical Implications of Onychodystrophy in Onychomycosis

Adigun¹,

Vlahovic²,

McClellan³

et al. 2017

J of Skin

View full text Add to dashboard Cite

show abstract

An investigation of how fungal infection influences drug penetration through onychomycosis patient’s nail plates

Abstract: Graphical abstract

Cited by 41 publications

References 35 publications

Preparation and Characterization of Caffeine Loaded Liposome and Ethosome Formulations for Transungual Application

Preparation and Characterization of Caffeine Loaded Liposome and Ethosome Formulations for Transungual Application

Onychomycosis in children: Safety and efficacy of antifungal agents

Efinaconazole 10% and Tavaborole 5% Penetrate Across Poly-ureaurethane 16%: Results of In Vitro Release Testing and Clinical Implications of Onychodystrophy in Onychomycosis

Contact Info

Product

Resources

About