An investigation of hearing impairment in de-novo Parkinson's disease patients: A preliminary study

Pisani, Valerio; Sisto, Renata; Moleti, Arturo; Mauro, Roberta Di; Pisani, Antonio; Brusa, Livia; Altavista, Maria Concetta; Stanzione, Paolo; Girolamo, Stefano Di

doi:10.1016/j.parkreldis.2015.06.007

Cited by 44 publications

(65 citation statements)

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“…Indeed, accumulation of Lewy bodies, the abnormal aggregates of α-synuclein, has been demonstrated at brainstem level of PD patients [16], suggesting that central neurodegeneration may contribute to PD auditory dysfunction. Moreover, in accordance with previous findings [6], we also observed a significant association between basal TEOAE and UPDRS III, which supports the idea of a common pathogenic mechanism underlying motor features and hearing impairment.…”

Section: 5supporting

confidence: 93%

“…Four PD patients and one ART were not included in our data analysis because of middle ear disease revealed by the acoustic impedance test The PD group, by history, showed a mean disease duration of 8.7 ± 1.1 years and, on clinical examination, a mean UPDRS III score of 9.64 ± 5.6 (range, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], H&Y staging ranged from 1.5 to 3 (mean 2.4 ± 1.2).…”

Section: Resultsmentioning

confidence: 99%

“…Dopamine receptors are also expressed on cholinergic medial olivocochlear system, that controls the motility of outer hair cells (OHC) and decrease the gain of the cochlear amplifier, but its role in hearing disorders is still unclear [15]. Indeed it has been recently shown that both cochlear dysfunction and hearing loss are levodopa-sensitive in PD patients [6].…”

Section: 5mentioning

confidence: 99%

“…The origin of hearing loss in PD has not been clarified yet; indeed it may be related to the physiological hypoacusis of aging, reaching 62% of population at the age of 85 [5]. Alternatively, it may also be determined by a specific impairment of neurotransmission of PD, resulting from the imbalance between glutamatergic and dopaminergic signaling [6]. Hearing loss could thus represent a peculiar sign of PD, being a candidate biomarker for the diagnosis and the progression of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Mauro¹,

Lazzaro²,

Schirinzi³

et al. 2017

J Alzheimers Dis Parkinsonism

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Section: 5supporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: 5mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Mauro¹,

Lazzaro²,

Schirinzi³

et al. 2017

J Alzheimers Dis Parkinsonism

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“…Previous studies by Yýlmaz et al [14], Vitale et al [15], Lai et al [16], and Pisani et al [17] reported greater hearing loss in PD patients compared to control groups without PD. Also, Guehl et al [18], Lewald et al [19], and Vitale et al [20] reported impaired auditory processing in PD patients compared to control groups.…”

Section: Introductionmentioning

confidence: 99%

Auditory Processing Abilities of Parkinson’s Disease Patients

Folmer

Vachhani

Theodoroff

et al. 2017

BioMed Research International

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Since Parkinson's Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests. Both study groups exhibited patterns of sensorineural hearing loss (slightly worse in the PD group) which were typical for their age and would contribute to difficulties in communication for many participants. Compared to the control group, PD patients reported greater difficulty in hearing words people are speaking. Although 27 PD patients (77%) were good candidates for amplification, only 7 (26%) of these hearing aid candidates used the devices. Because it is important for PD patients to optimize communication with their family members, caregivers, friends, and clinicians, it is vital to identify and remediate auditory dysfunction in this population as early as possible.

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Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population

et al. 2022

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IMPORTANCEEarly features of Parkinson disease (PD) have been described through population-based studies that overrepresent White, affluent groups and may not be generalizable.OBJECTIVE To investigate the association between risk factors and prediagnostic presentations of PD in an ethnically diverse UK population with high socioeconomic deprivation but universal access to health care. DESIGN, SETTING, AND PARTICIPANTSA nested case-control study was conducted using electronic health care records on 1 016 277 individuals from primary care practices in East London to extract clinical information recorded between 1990 and February 6, 2018. The data were analyzed between September 3, 2020, and September 3, 2021. Individuals with a diagnosis of PD were compared with controls without PD or other major neurological conditions. MAIN OUTCOMES AND MEASURESA matched analysis (10 controls matched for each patient with PD according to age and sex) and an unmatched analysis (adjusted for age and sex) were undertaken using multivariable logistic regression to determine associations between risk factors and prediagnostic presentations to primary care with subsequent diagnosis of PD. Three time periods (<2, 2-<5, and 5-10 years before diagnosis) were analyzed separately and together.RESULTS Of 1 016 277 individuals included in the data set, 5699 were excluded and 1055 patients with PD and 1 009 523 controls were included in the analysis. Patients with PD were older than controls (mean [SD], 72.9 [11.3] vs 40.3 [15.2] years), and more were male (632 [59.9%] vs 516 862 [51.2%]). In the matched analysis (1055 individuals with PD and 10 550 controls), associations were found for tremor (odds ratio [OR], 145.96; 95% CI, 90.55-235.28) and memory symptoms (OR, 8.60; 95% CI, 5.91-12.49) less than 2 years before the PD diagnosis. The associations were also found up to 10 years before PD diagnosis for tremor and 5 years for memory symptoms. Among midlife risk factors, hypertension (OR, 1.36; 95% CI,) and type 2 diabetes (OR, 1.39; 95% CI, 1.19-1.62) were associated with subsequent diagnosis of PD. Associations with early nonmotor features, including hypotension (OR, 6.84; 95% CI, 3.38-13.85), constipation (OR, 3.29; 95% CI, 2.32-4.66), and depression (OR, 4.69; 95% CI, 2.88-7.63), were also noted. Associations were found for epilepsy (OR, 2.5; 95% CI, 1.63-3.83) and hearing loss (OR, 1.66; 95% CI, 1.06-2.58), which have not previously been well reported. These findings were replicated using data from the UK Biobank. No association with future PD diagnosis was found for ethnicity or deprivation index level. CONCLUSIONS AND RELEVANCEThis study provides data suggesting that a range of comorbidities and symptoms are encountered in primary care settings before PD diagnosis in an ethnically diverse and deprived population. Novel temporal associations were observed for epilepsy and hearing loss with subsequent development of PD. The prominence of memory symptoms suggests an excess of cognitive dysfunction in early PD in this population or difficul...

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An investigation of hearing impairment in de-novo Parkinson's disease patients: A preliminary study

Cited by 44 publications

References 11 publications

Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Auditory Processing Abilities of Parkinson’s Disease Patients

Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population

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