An investigation of antibiofilm and cytotoxic property of MgO nanoparticles

MubarakAli, D.; Manzoor, Muhammed A.P.; Sabarinathan, A.; Devi, C. Anchana; Rekha, P. D.; Thajuddin, Nooruddin; Lee, Sang-Yul

doi:10.1016/j.bcab.2019.101069

Cited by 22 publications

(4 citation statements)

References 36 publications

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“…Based on the results, adding Ag to taC is a possible reason for the enhanced biofilm inhibition in the test pathogens. In accordance with the findings, the Ag, Cu, and MgO nanoparticles synthesized have a similar effect on the biofilm formation of other pathogens, such as E. coli, S. aureus, and P. aeruginosa [2,[49][50][51].…”

Section: Resultssupporting

confidence: 88%

Synthesis of Ag-Doped Tetrahedral Amorphous Carbon Coatings and Their Antibiofilm Efficacy for Medical Implant Application

MubarakAli,

Kim,

et al. 2024

Nanomaterials

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Tetrahedral amorphous carbon (taC) is a hydrogen-free carbon with extensive properties such as hardness, optical transparency, and chemical inertness. taC coatings have attracted much attention in recent times, as have coatings doped with a noble metal. A known antimicrobial metal agent, silver (Ag), has been used as a dopant in taC, with different Ag concentrations on the Ti64 coupons using a hybrid filtered cathodic vacuum arc (FCVA) and magnetron sputtering system. The physiochemical properties of the coated surface were investigated using spectroscopic and electron microscopy techniques. A doping effect of Ag-taC on biofilm formation was investigated and found to have a significant effect on the bacterial-biofilm-forming bacteria Staphylococcus aureus and Pseudomonas aeruginosa depending on the concentration of Ag. Further, the effect of coated and uncoated Ag-taC films on a pathogenic bacterium was examined using SEM. The result revealed that the Ag-taC coatings inhibited the biofilm formation of S. aureus. Therefore, this study demonstrated the possible use of Ag-taC coatings against biofilm-related complications on medical devices and infections from pathogenic bacteria.

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Section: Resultssupporting

confidence: 88%

Synthesis of Ag-Doped Tetrahedral Amorphous Carbon Coatings and Their Antibiofilm Efficacy for Medical Implant Application

MubarakAli,

Kim,

et al. 2024

Nanomaterials

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“…Furthermore, MubarakAli and colleagues [181] fabricated magnesium oxide nanoparticles through a facile co-precipitation synthetic approach and evaluated their cytotoxic effect towards human breast cancer cells (MCF-7). Based on their study, the magnesium oxide nanoparticles successfully restrained the viability of MCF-7 cells at a concentration equal to 50 µg/mL.…”

Section: Anticancer Activitymentioning

confidence: 99%

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine.

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“…In this regard, the drug-loaded nanoparticles have mostly been studied in vitro, and little is known about their potential in animal models. However, some nanoformulations have shown promising results in animal models, namely, silver [ 119 ], copper [ 127 , 235 , 236 ], magnesium oxide [ 237 ], polymeric [ 180 ], and silica nanoparticles [ 216 ]. Meanwhile, the use of drug-loaded nanoparticles in food systems has gained considerable attention from regulatory boards regarding the consumers’ health after ingesting food products with residual nanoparticles [ 238 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Exploring Possible Ways to Enhance the Potential and Use of Natural Products through Nanotechnology in the Battle against Biofilms of Foodborne Bacterial Pathogens

Kannappan

Prasath²,

Sathya

et al. 2023

Pathogens

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Biofilms enable pathogenic bacteria to survive in unfavorable environments. As biofilm-forming pathogens can cause rapid food spoilage and recurrent infections in humans, especially their presence in the food industry is problematic. Using chemical disinfectants in the food industry to prevent biofilm formation raises serious health concerns. Further, the ability of biofilm-forming bacterial pathogens to tolerate disinfection procedures questions the traditional treatment methods. Thus, there is a dire need for alternative treatment options targeting bacterial pathogens, especially biofilms. As clean-label products without carcinogenic and hazardous potential, natural compounds with growth and biofilm-inhibiting and biofilm-eradicating potentials have gained popularity as natural preservatives in the food industry. However, the use of these natural preservatives in the food industry is restricted by their poor availability, stability during food processing and storage. Also there is a lack of standardization, and unattractive organoleptic qualities. Nanotechnology is one way to get around these limitations and as well as the use of underutilized bioactives. The use of nanotechnology has several advantages including traversing the biofilm matrix, targeted drug delivery, controlled release, and enhanced bioavailability, bioactivity, and stability. The nanoparticles used in fabricating or encapsulating natural products are considered as an appealing antibiofilm strategy since the nanoparticles enhance the activity of the natural products against biofilms of foodborne bacterial pathogens. Hence, this literature review is intended to provide a comprehensive analysis of the current methods in nanotechnology used for natural products delivery (biofabrication, encapsulation, and nanoemulsion) and also discuss the different promising strategies employed in the recent and past to enhance the inhibition and eradication of foodborne bacterial biofilms.

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An investigation of antibiofilm and cytotoxic property of MgO nanoparticles

Cited by 22 publications

References 36 publications

Synthesis of Ag-Doped Tetrahedral Amorphous Carbon Coatings and Their Antibiofilm Efficacy for Medical Implant Application

Synthesis of Ag-Doped Tetrahedral Amorphous Carbon Coatings and Their Antibiofilm Efficacy for Medical Implant Application

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Exploring Possible Ways to Enhance the Potential and Use of Natural Products through Nanotechnology in the Battle against Biofilms of Foodborne Bacterial Pathogens

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