An investigation into the toxicity of tissue extracts from two distinct marine Polychaeta

D’Ambrosio, Mariaelena; Ramos, Íris; Martins, Carla; Costa, Pedro M.

doi:10.1016/j.toxcx.2022.100116

Cited by 7 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glycera alba (a burrowing ambush predator) secretes toxins through the proboscis to overpower its highly motile prey, while H. diversicolor has been hypothesized to secrete noxious biomolecules (proteins and secondary metabolites) through the skin mostly for defense against potential predators and pathogens while foraging, as suggested elsewhere based on microanatomical and histochemical data. 21,67 These findings agree with the expression of toxins in venom glands that has been described in other Glycera, 6 as well as in further predatory Polychaeta whose proboscis secrete thiol-rich toxins. 21 Moreover, a recent study showed that tissue extracts from the proboscis of G. alba and the skin of H. diversicolor provoke more DNA damage on the gills of mussels compared to the control, suggesting the secretion of toxins from both of these two organs.…”

Section: Identification Of Potential Venom Components In the Transcri...supporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

“…21 Moreover, a recent study showed that tissue extracts from the proboscis of G. alba and the skin of H. diversicolor provoke more DNA damage on the gills of mussels compared to the control, suggesting the secretion of toxins from both of these two organs. 67 Distinct venom apparatuses and predatory behaviors can also be indicative of differential specificity of toxins towards molecular and cellular targets. Since G. alba injects toxins and other venom components to overwhelm its prey, this could suggest an investment in toxins with increased specificity (e.g., neurotoxins), which is adjuvated by permeabilizing enzymes, whereas H. diversicolor's secretions may have a broader action as they might passively diffuse through mucus and water.…”

Section: Identification Of Potential Venom Components In the Transcri...mentioning

confidence: 99%

See 2 more Smart Citations

A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids: Glycera alba and Hediste diversicolor

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Identification Of Potential Venom Components In the Transcri...supporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Identification Of Potential Venom Components In the Transcri...mentioning

confidence: 99%

See 1 more Smart Citation

A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids: Glycera alba and Hediste diversicolor

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…DNA breaks were produced in mussel gills by a skin extract from Hediste diversicolor and Glycera alba jaw proboscis. It was suggested that H. diversicolor secretes toxins via the skin for protection against predators, but G. alba secretes toxins for predation [ 62 ].…”

Section: Results Of Literature Searchmentioning

confidence: 99%

A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin

Sjakste

Gajski

2023

Toxins

View full text Add to dashboard Cite

Envenomation by animal venoms remains a serious medical and social problem, especially in tropical countries. On the other hand, animal venoms are widely used as a source of biologically active compounds for the development of novel drugs. Numerous derivatives of animal venoms are already used in clinical practice. When analysing the mechanisms of action of animal venoms, attention is usually focused on the main target of the venom’s enzymes and peptides such as neurotoxic, cytotoxic or haemorrhagic effects. In the present review, we would like to draw attention to the “hidden” effects of animal venoms and their derivatives in regard to DNA damage and/or protection against DNA damage. Alkaloids and terpenoids isolated from sponges such as avarol, ingenamine G or variolin B manifest the capability to bind DNA in vitro and produce DNA breaks. Trabectidin, isolated from a sea squirt, also binds and damages DNA. A similar action is possible for peptides isolated from bee and wasp venoms such as mastoparan, melectin and melittin. However, DNA lesions produced by the crude venoms of jellyfish, scorpions, spiders and snakes arise as a consequence of cell membrane damage and the subsequent oxidative stress, whereas certain animal venoms or their components produce a genoprotective effect. Current research data point to the possibility of using animal venoms and their components in the development of various potential therapeutic agents; however, before their possible clinical use the route of injection, molecular target, mechanism of action, exact dosage, possible side effects and other fundamental parameters should be further investigated.

show abstract

“…A recent paper on the venom of the ribbon worm Antarctonemertes valida [ 10 ] revealed distinct defensive and predatory toxins, a scenario analogous to the separate defensive and predatory venoms produced by some cone snails ( Conus spp.) [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Envenoming by a Marine Blood Worm (Glycera)

Durkin

Young²,

Khtikian³

et al. 2022

Toxins

View full text Add to dashboard Cite

Bites from venomous marine annelid ‘bloodworms’ (e.g., Glycera spp.) do not appear to have been described in the medical literature despite being seemingly well-known to bait diggers and fishermen. The few laboratory study reports describe their venom composition and physiological effects in vitro to be primarily proteolytic enzymes and neurotoxins apparently used for predation and defense. Herein, we present the report of a symptomatic envenoming suffered by a marine ecologist bitten while performing her field research. The local effects included a rapid onset of pain, swelling, and numbness at the bite site “as if injected with local anesthetic”. Additional signs and symptoms appearing over a two-week period were consistent with both delayed venom effects and potentially secondary infection. The late signs and symptoms resolved during a course of antibiotic treatment with doxycycline prescribed as a precaution and lack of resources to consider a wound culture. Comments about annelid bites sporadically appear in the popular literature, especially pertaining to the fishing industry, under names such as ‘bait-diggers hand’. While these bites are not known to be dangerously venomous, they seem to produce painful local symptoms and possibly increase the risk of marine bacterial infections that could be associated with more serious outcomes. More cases need to be formally described to better understand the natural history of these types of envenomation.

show abstract

An investigation into the toxicity of tissue extracts from two distinct marine Polychaeta

Cited by 7 publications

References 20 publications

A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids: Glycera alba and Hediste diversicolor

A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids: Glycera alba and Hediste diversicolor

A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin

Envenoming by a Marine Blood Worm (Glycera)

Contact Info

Product

Resources

About