An Investigation into the Serum Thioredoxin, Superoxide Dismutase, Malondialdehyde, and Advanced Oxidation Protein Products in Patients with Breast Cancer

Kılıç, Nedret; Taşlıpınar, Mine Yavuz; Güney, Yıldız; Tekin, Ercüment; Onuk, Erhan

doi:10.1245/s10434-014-3859-3

Cited by 49 publications

(28 citation statements)

References 25 publications

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“…Trx-1 stimulates MMP-9 expression and promotes MMP-9 dependent invasion in breast cancer cells [12]. Thioredoxin system is highly expressed in breast tumors [23,24] and Trx-1 has been previously suggested as a suitable and diagnostic biomarker for breast cancer [8,13]. Our results extend these previous studies to show that Trx-1 level is significantly increased in breast cancer patients as compared to control.…”

Section: Discussionsupporting

confidence: 85%

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Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients

Salam

Ebrahim

Eissa

et al. 2018

Egyptian Journal of Basic and Applied Sciences

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Patients were classified according to the American Joint Committee on Cancer (AJCC) TNM system [16] to stage 0 (3 patients), stage I (9 patients), stage II (12 patients), stage III (13 patients) and stage IV (38 patients). The patients and controls do not have renal, liver disorders or any other type of malignancies. Recorded clinical and pathological features for each patient were obtained from Oncology Center including age, grade, stage, serum

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Section: Discussionsupporting

confidence: 85%

“…In addition, ROS initiate lipid peroxidation of polyunsaturated fatty acids in cell membrane producing malondialdehyde (MDA). MDA used as biomarker of oxidative stress and play an important role in breast cancer initiation, progression and metastasis [13].…”

Section: Introductionmentioning

confidence: 99%

Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients

Salam

Ebrahim

Eissa

et al. 2018

Egyptian Journal of Basic and Applied Sciences

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“…Letrozole slightly augments ROS (34) and ASD concentrations (18). Breast cancer (33) or incidental inflammatory processes (48) may boost oxidative stress, thus increasing the possibility of the simultaneous presence of the three TRPA1 stimulants. However, the current hypothesis does not exclude that additional agents, able to activate or sensitize the TRPA1, may act along with AIs and ASD to reach the threshold for AIMSS generation.…”

Section: Discussionmentioning

confidence: 99%

TRPA1 Mediates Aromatase Inhibitor–Evoked Pain by the Aromatase Substrate Androstenedione

et al. 2016

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Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of patients, we hypothesized that additional factors may cooperate to induce AIMSS. Here we report that the aromatase substrate androstenedione, unique among several steroid hormones, targeted TRPA1 in peptidergic primary sensory neurons in rodent and human cells expressing the native or recombinant channel. Androstenedione dramatically lowered the concentration of letrozole required to engage TRPA1. Notably, addition of a minimal dose of androstenedione to physiologically ineffective doses of letrozole and oxidative stress byproducts produces AIMSS-like behaviors and neurogenic inflammatory responses in mice. Elevated androstenedione levels cooperated with low letrozole concentrations and inflammatory mediators were sufficient to provoke AIMSS-like behaviors. The generation of such painful conditions by small quantities of simultaneously administered TRPA1 agonists justifies previous failure to identify a precise link between AIs and AIMSS, underscoring the potential of channel antagonists to treat AIMSS. Cancer Res; 76(23); 7024-35. Ó2016 AACR.

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“…To the best of our knowledge, to date, no other study has examined the relation of auditory processing with the variables here investigated, but many authors have already described an association, for example, of high levels of AOPP with different implications: nephrology [Descamps-Latscha et al, 2005], cardiac disease [Feng et al, 2010], depression [Vargas et al, 2013], diabetes [Korkmaz et al, 2013], autistic spectrum [Rossignol and Frye, 2012], and different types of cancer [Maia Ribeiro et al, 2013;Kilic et al, 2014].…”

Section: Discussionmentioning

confidence: 99%

Impact of Lipid-Inflammatory-Oxidative Metabolism on Auditory Skills after Hearing Aid Fitting in the Elderly

Lessa

Cruz²,

Manica-Cattani³

et al. 2017

Audiol Neurotol

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This study aimed to assess whether lipid-inflammatory-oxidative metabolism influences auditory processing skills, and whether they function in changing auditory performance after hearing aid fitting in the elderly. Twelve subjects with bilateral hearing loss were submitted to blood tests (to check their lipid-inflammatory-oxidative metabolism) and auditory processing skill tests. After 3 months of using the hearing aids, their auditory skills were re-evaluated and the data were correlated statistically. Oxidative stress levels mainly showed some impact on auditory temporal processing; such a relation and others should best be examined in further studies with larger populations.

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An Investigation into the Serum Thioredoxin, Superoxide Dismutase, Malondialdehyde, and Advanced Oxidation Protein Products in Patients with Breast Cancer

Cited by 49 publications

References 25 publications

Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients

Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients

TRPA1 Mediates Aromatase Inhibitor–Evoked Pain by the Aromatase Substrate Androstenedione

Impact of Lipid-Inflammatory-Oxidative Metabolism on Auditory Skills after Hearing Aid Fitting in the Elderly

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