An Investigation into the Rheology of Pharmaceutical Inter-granular Material Bridges at High Shear Rates

Crean, Barry; Chen, Xinyong; Banks, Simon R.; Cook, W. G.; Melia, Colin D.; Roberts, Clive J.

doi:10.1007/s11095-009-9828-z

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Granular materials are assemblies of solid discrete granules and granular material flows have extensive use in industries, such as granular lubrication, powder metallurgy, transport of sand and grains [1][2][3][4]. Granular material flow displays many characteristics preventing them from being simply categorized as either classical fluids or solids [5].…”

Section: Introductionmentioning

confidence: 99%

Fluctuation and self-diffusion research about dry granular materials under shearing

Meng

Hua

et al. 2019

J Braz. Soc. Mech. Sci. Eng.

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Flow and self-diffusion behaviors of granules in sheared granular systems are a typical study field but still not yet fully grasped because of the complexities and discreteness of granular matter systems. This paper presents a discrete element method-based simulation research of the fluctuation and self-diffusion characteristics of granules in a dense sheared granular system. Simulation results show that the average velocity of granules decreases with the altitude location, which is reverse to the variation of fluctuation velocity. It is noted that the model channel can be classified into "solid-like," "oscillating" and "fluid-like" region according to the magnitude of shear rate and fluctuation velocity of granules. The self-diffusion of granules is greater in the "solid-like" region, but smaller in the "fluid-like" region. These findings emphasize the importance of research on macroscopic dynamics of granules, such as rearrangement and self-diffusion of granular matter systems.

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Section: Introductionmentioning

confidence: 99%

Fluctuation and self-diffusion research about dry granular materials under shearing

Meng

Hua

et al. 2019

J Braz. Soc. Mech. Sci. Eng.

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“…Increased interest in AFM as a characterisation technique, along with the production of more accessible instruments with a range of novel analysis modes has led to new, innovative approaches to materials characterisation such as the assessment of rheological properties (Crean et al, 2009) and the incorporation of a condenser (Kwek et al, 2011) to determine particle charges via AFM. Referring back to the review of AFM adhesion measurements of interparticulate forces by Roberts (2005), much progress has been made in the last decade.…”

Section: Discussionmentioning

confidence: 99%

“…While three different scenarios describing the process of particle detachment-lift-off, sliding and rolling-are possible, a combination of colloidal probe measurements, simulations and computational modelling identified the rolling mechanism, closely followed by sliding, as the main mechanisms of particle detachment. Crean et al (2009) developed a novel AFM-based technique for rheological measurements. The group used colloidal probe AFM to determine the rheology of inter-granular bridges between lactose and polyvinylpyrrolidone particles at different RH.…”

Section: Adhesion Measurementsmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Continuous Single-Step Wet Granulation with Integrated in-Barrel-Drying

et al. 2018

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An Investigation into the Rheology of Pharmaceutical Inter-granular Material Bridges at High Shear Rates

Abstract: AFM has been employed as a rheometer to investigate the nano-scale rheology of inter-granular material bridges. This novel method may be used to obtain a fundamental understanding how different binders, granulated with different diluent fillers, behave at high shear rates.

Cited by 3 publications

References 14 publications

Fluctuation and self-diffusion research about dry granular materials under shearing

Fluctuation and self-diffusion research about dry granular materials under shearing

Characterisation of dry powder inhaler formulations using atomic force microscopy

Continuous Single-Step Wet Granulation with Integrated in-Barrel-Drying

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