An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract ofPlumbago zeylanica

Olagunju, J. A.; Jobi, A. A.; Oyedapo, O. O.

doi:10.1002/(sici)1099-1573(199906)13:4<346::aid-ptr444>3.0.co;2-d

Cited by 40 publications

(23 citation statements)

References 8 publications

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“…The roots of P. zeylanica L. (Plumbaginaceae), locally known as 'Amira', are also used to treat various ailments, including malaria and various topical and systemic microbial infections (Abebe and Ayehu, 1993;Ahmad et al, 1998;Olagunju et al, 1999; GebreMariam et al, 2006). The major chemical constituents seem to be plumbagin and various plumbagic acid glycosides and coumarins …”

mentioning

confidence: 99%

Potential genotoxicity of plant extracts used in Ethiopian traditional medicine

Demma

Engidawork

Hellman

2009

Journal of Ethnopharmacology

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mentioning

confidence: 99%

Potential genotoxicity of plant extracts used in Ethiopian traditional medicine

Demma

Engidawork

Hellman

2009

Journal of Ethnopharmacology

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“…PZ is being used as hepatoprotective and also added to several herbal or ayurvedic formulations like Liv-52, Chitraka haritaki and Yograjguggal, prescribed to treat various hepatic insufficiencies like liver enlargement, jaundice, Science Publications AJPT cirrhosis (Karandikar et al, 1963;Tilak et al, 2004). Moreover, PZ is also reported to have anti-atherogenic, anti-hyperglycemic, anticancer, anti-ulcer, anti-pyretic and antibacterial activities (Lin et al, 2003;Olagunju et al, 1999).…”

Section: Plumbagomentioning

confidence: 99%

POSSIBLE MECHANISM OF <i>PLUMBAGO ZEYLANICA</i> IN PREVENTION OF HEPATIC DAMMAGE IN WISTAR RAT

Goyal¹

2012

American Journal of Pharmacology and Toxicology

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Plumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl 4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kgto Wistar albino rats (180-240 g of either sex, n = 8) caused significant increase in serum ALT, AST, ALP and bilirubin; tissue lipid peroxidation, nitrite/nitrate, collagen; and decrease in tissue GSH and SOD levels. The liver histopathology revealed central vein dilation, infiltration and fatty degeneration in hepatotoxicant control groups. Pretreatment with methanolic extract of Plumbago zeylanica (100, 200 and 400 mg kg −1 ) and silymarin (50 mg kg −1 ) as standard significantly reversed these toxic changes dose dependently, as compared to hepatotoxicant control. The results in present study suggested that Plumbago zeylanica root possesses marked hepatoprotective potential through its oxidative, inflammatory and fibrotic effects against experimentally induced liver toxicity. These findings support and extend the rational basis for the use of this plant as hepatoprotective in traditional and folk-lore medicine.

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“…The anticancer property of PLN against HeLa, P388 lymphocytic, leukemia, colon cancer and hepatoma has been reported (Aziz et al, 2008;Kuo et al, 2006;Lin et al, 2003;Olagunju et al, 1999;Srinivas et al, 2004). Our group carried out the studies on plumbagin metal-based antitumour agents.…”

Section: Plumbagin-metal Based Anticancer Agentsmentioning

confidence: 99%