An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines

You, Jungmok; Madigan, Michele C.; Rowe, Alexandra; Sajinovic, Mila; Russell, Pamela J.; Jackson, Paul

doi:10.1016/j.urolonc.2010.02.013

Cited by 14 publications

(18 citation statements)

References 35 publications

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“…These results are consistent with previous data that KAI1/CD82 expression is associated with increased invasive behavior of solid tumors [7,26,29]. In analyzed glioma specimens overexpression of KAI1/CD82 was observed in glioma cells without malignancy features regardless of the tumor grade whereas the majority of malignant cells were negative for KAI1/CD82 immunostaining.…”

Section: Discussionsupporting

confidence: 92%

“…Our results demonstrate that parallel expression of both biomarkers in glioblastomas might identify the cases where KAI1/CD82 might lead to a reduction in PDGFRβ activity and probably inhibit angiogenesis dependent on PDGFRβ expression. Our observations are partly consistent with the studies reporting that the KAI1/CD82 attenuated pathway depends of receptor tyrosine kinase (RTKs) activity [7,24,29]. Based on earlier reports which describe the association between KAI1/CD82 and surface receptor responsible for a different signaling pathway we suggest that such mechanism may occur in gliomas [31].…”

Section: Discussionsupporting

confidence: 92%

“…Downregulation of both KAI1/CD82 mRNA and protein expression is observed during progression and increased invasive behavior of tumors [7,15,30]. Several mechanisms have been proposed by which KAI1/CD82 might influence and control tumor cell behavior [29]. It was established that KAI1/CD82 plays an important role in regulating melanoma cell migration through the controlling of Rho and GTPases signaling activity [23].…”

Section: Introductionmentioning

confidence: 99%

“…Another study revealed that KAI1/CD82 might have an inhibitory role in the PI3K/AKT pathway [1,6,23]. So far, the correlation between KAI1/CD82 expression and the signal transduction pathway has been examined in breast and ovarian cancers [29].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of the expression of KAI1/CD82 and PDGFRβ and their impact on glioma progression

Paradowski

Bilińska

Bär

2016

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A b s t r a c t The biological features of glioma cells may define their clinical outcome. Little is known about the interactions between KAI1/CD82 metastatic suppressor protein and PDGFRβ in gliomas. The aim of the study was to examine KAI1/CD82 and PDGFRβ expression in gliomas in order to find the impact of these proteins on progression of the tumors. PDGFRβ, KAI1/CD82 protein expression and mRNA of genes were evaluated on eighty four paraffin-embedded tissue of gliomas using immunohistochemical staining and RT-PCR analysis. The PDGFRβ expression was higher in IV/III than in I/II glioma grades (p = 0.0004). The level of mRNA PDGFRβ was associated with the degree of PDGFRβ immunoreactivity. Downregulation of KAI1/CD82 was associated with tumor malignancy (p = 0.007). The increased level of KAI1/CD82 gene expression (3-4-fold) was found in gliomas with

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characteristics of the expression of KAI1/CD82 and PDGFRβ and their impact on glioma progression

Paradowski

Bilińska

Bär

2016

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“…In our study, we might consider such regulation of MMP-2 and MMP-9 by isoforms of ERa, b, PR-A, and PR-B playing different biological functions in tumor cells [19]. Our data, showing a positive relation between KAI1 and MMP-2 expression in endometrial cancers, are partly consistent with recently published results which have shown a relationship between the expression of KAI1, MMP-2, and MMP-9 in bladder cancer cell lines [30]. The authors of that study showed that poorly invasive KAI1-positive cell lines express high levels of MMP-2 mRNA and (pro-MMP-2) protein, whereas cell lines that are KAI1-negative and possess an invasive phenotype show no detectable MMP-2 mRNA expression [30].…”

Section: Discussionsupporting

confidence: 92%

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Gryboś

Bär

2014

Folia Histochem Cytobiol.

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Abstract:The role of the parallel expression of the KAI1 protein and metalloproteinases (MMP-2 and MMP-9) in respect to the status of steroid receptors in endometrial cancer is still incompletely understood. The aim of this study was to evaluate the expression of and correlation between KAI1 on one hand and MMP-2 and MMP-9 on the other hand in terms of the status of the estrogen (ER) and progesterone receptors (PR) in 100 patients with endometrial cancer. The expressions of KAI1, MMP-2, MMP-9, ER and PR were assessed immunohistochemically on paraffin-embedded tissues. No correlations were found between these biomarkers and the clinical and pathological parameters of the endometrial cancer. However, in KAI1-positive cases, the expression was limited to a small area of tumor tissue in FIGO stages III-IV. A tendency towards the high expression of MMP-9 and MMP-2 was observed in the advanced stages of endometrial cancer (FIGO IIIA-IV). Positive correlations between the presence of KAI1 and PR and between the presence of MMP-9 and PR were found in endometrial cancer. A positive correlation was also observed between KAI1 and MMP-2 expression, and a borderline one between KAI1 and MMP-9 expression in endometrial cancer. KAI1 -/MMP-2 + and KAI1 -/MMP-9 + phenotypes were more often observed in FIGO stage II. Our study showed that KAI1 protein, as well as steroid receptors, might modulate MMP-2 and MMP-9 expression in endometrial cancer. Our study revealed that the overlapping expression of the biomarkers investigated here suggests that cooperation between these molecules exists, even at the early stages of endometrial cancer growth, and may determine the speed of tumor cell dissemination and might characterize the biological behavior of endometrial cancer.

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Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity

Feng

Huang

Wren

et al. 2015

Cancer Metastasis Rev

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Tetraspanin CD82 suppresses the progression and metastasis of a wide range of solid malignant tumors. However, its roles in tumorigenesis and hematopoietic malignancy remain unclear. Ubiquitously expressed CD82 restrains cell migration and cell invasion by modulating both cell-matrix and cell-cell adhesiveness and confining outside-in pro-motility signaling. This restraint at least contributes to, if not determines, the metastasis-suppressive activity and, also likely, the physiological functions of CD82. As a modulator of cell membrane heterogeneity, CD82 alters microdomains, trafficking, and topography of the membrane by changing the membrane molecular landscape. The functional activities of membrane molecules and the cytoskeletal interaction of the cell membrane are subsequently altered, followed by changes in cellular functions. Given its pathological and physiological importance, CD82 is a promising candidate for clinically predicting and blocking tumor progression and metastasis and also an emerging model protein for mechanistically understanding cell membrane organization and heterogeneity.

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An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines

Cited by 14 publications

References 35 publications

Characteristics of the expression of KAI1/CD82 and PDGFRβ and their impact on glioma progression

Characteristics of the expression of KAI1/CD82 and PDGFRβ and their impact on glioma progression

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity

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