An inverse-designed electrochemical platform for analytical applications

Cancelliere, Rocco; Tinno, Alessio Di; Lellis, A. M. Di; Tedeschi, Yannick; Bellucci, Stefano; Carbone, Katya; Signori, Emanuela; Contini, G.; Micheli, Laura

doi:10.1016/j.elecom.2020.106862

Cited by 14 publications

(15 citation statements)

References 27 publications

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“…The following current results were obtained: 29.4 ± 0.5, 40 ± 1, 35 ± 9 nA, and 132 ± 14 nA for SWNTs, MWNTs, GNPs, and bare SPEs, respectively. By using the standard deviation [ 50 ] as the index of signal/noise ratio, it was possible to ascertain that the modification with CNMs produced a more dependable electrochemical device with an important minimization of capacitive current. After that, six different platforms ( n = 6) for each modified-SPEs were analyzed voltammetrically (CV) using the reversible couple (10 mM) [Fe(CN) 6 ] 3-/4- as an electroactive reporter.…”

Section: Resultsmentioning

confidence: 99%

“…Spectrophotometric methods have also been used [ 44 , 45 , 46 , 47 , 48 , 49 ]. Although these methods to measure HQ and BQ levels have been demonstrated to be effective, they still require a minimum of in-presence sample processing and high employment of reagents and time [ 50 , 51 ]. In this context, electrochemical sensors represent a valid alternative to the traditional staple techniques due to their instrumental simplicity, cost-effectiveness, and portability [ 50 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although these methods to measure HQ and BQ levels have been demonstrated to be effective, they still require a minimum of in-presence sample processing and high employment of reagents and time [ 50 , 51 ]. In this context, electrochemical sensors represent a valid alternative to the traditional staple techniques due to their instrumental simplicity, cost-effectiveness, and portability [ 50 , 52 ]. Indeed, several works have been reported in the literature where electrochemical methods are used for the determination of quinones.…”

Section: Introductionmentioning

confidence: 99%

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Sensitive Detection of Industrial Pollutants Using Modified Electrochemical Platforms

et al. 2022

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Water pollution is nowadays a global problem and the effective detection of pollutants is of fundamental importance. Herein, a facile, efficient, robust, and rapid (response time < 2 min) method for the determination of important quinone-based industrial pollutants such as hydroquinone and benzoquinone is reported. The recognition method is based on the use of screen-printed electrodes as sensing platforms, enhanced with carbon-based nanomaterials. The enhancement is achieved by modifying the working electrode of such platforms through highly sensitive membranes made of Single- or Multi-Walled Carbon Nanotubes (SWNTs and MWNTs) or by graphene nanoplatelets. The modified sensing platforms are first carefully morphologically and electrochemically characterized, whereupon they are tested in the detection of different pollutants (i.e., hydroquinone and benzoquinone) in water solution, by using both cyclic and square-wave voltammetry. In particular, the sensors based on film-deposited nanomaterials show good sensitivity with a limit of detection in the nanomolar range (0.04 and 0.07 μM for SWNT- and MWNT-modified SPEs, respectively) and a linear working range of 10 to 1000 ppb under optimal conditions. The results highlight the improved performance of these novel sensing platforms and the large-scale applicability of this method for other analytes (i.e., toxins, pollutants).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sensitive Detection of Industrial Pollutants Using Modified Electrochemical Platforms

et al. 2022

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“…Taking a look at the literature, Cancelliere et al used biochar obtained from brewer waste to improve the properties of an interesting inverse-designed graphite SPE; using Fe[(CN) 6 ] 4–/3– as a redox probe, Δ E = 205 mV (50 mV s –1 ) and K 0 of 1.8 × 10 –3 cm s –1 were obtained. The same group, using another type of biochar, demonstrated comparable results, modifying graphite-SPE ( K 0 = 2.3 × 10 –3 cm s –1 ) .…”

Section: Resultsmentioning

confidence: 99%

Water-Phase Exfoliated Biochar Nanofibers from Eucalyptus Scraps for Electrode Modification and Conductive Film Fabrication

Bukhari

Silveri

Pelle

et al. 2021

ACS Sustainable Chem. Eng.

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A solvent-free strategy to produce water-dispersed biochar-nanofibers (BH-CNF) is reported, demonstrating the potential of this cost-effective and sustainable material in electrochemical sensing and fabrication of conductive films. Water-phase BH-CNF from eucalyptus scraps were achieved using a Kraft process followed by liquid-phase exfoliation assisted by the biological stabilizing agent sodium cholate. BH-CNF-based sensors were constructed following two strategies: surface modification of screen-printed electrodes and fabrication of exclusively nanofiber-based flexible sensors. The latter were fabricated through a procedure that is cost-effective and within everyone’s reach. The potentiality of the BH-CNF-based sensors has been challenged toward a wide range of analytes containing phenol moieties and applied for detection of o-diphenols and m-phenols in olive oil samples. The BH-CNF-based sensors exhibited repeatable (RSD ≤ 7%, n = 5) and reproducible (RSD ≤ 10%; n = 3) results, proving their applicability in electroanalytical applications and the robustness of the exfoliation and fabrication strategy. For sample analysis, LODs for hydroxytyrosol (LOD ≤ 0.6 μM) and tyrosol (LOD ≤ 3.8 μM), intersensor precision (RSD calibration slope < 7%, n = 3), and recoveries obtained in real sample analysis (91–111%, RSD ≤ 6%; n = 3) endorse the material exploitability in real analytical applications.

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“…Critical importance in electroanalytical measurement is given to the magnitude of the electrochemical response and its reproducibility. There are different ways in which this target can be achieved: first, improving the electron transfer conductivity of the transducers; second, reshaping the geometry of the working or reference electrode [ 1 ] (avoiding post-printing modification procedure); finally, attempting to alter the surface area of the electrode. Among these, the electronic transfer is the cardinal attribute behind all the different electrochemical sensors.…”

Section: Introductionmentioning

confidence: 99%

Powerful Electron-Transfer Screen-Printed Platforms as Biosensing Tools: The Case of Uric Acid Biosensor

et al. 2021

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The use of carbon nanomaterials (CNMs) in sensors and biosensor realization is one of the hottest topics today in analytical chemistry. In this work, a comparative in-depth study, exploiting different nanomaterial (MWNT-CO2H, -NH2, -OH and GNP) modified screen-printed electrodes (SPEs), is reported. In particular, the sensitivity, the heterogeneous electron transfer constant (k0), and the peak-to-peak separation (ΔE) have been calculated and analyzed. After which, an electrochemical amperometric sensor capable of determining uric acid (UA), based on the nano-modified platforms previously characterized, is presented. The disposable UA biosensor, fabricated modifying working electrode (WE) with Prussian Blue (PB), carbon nanotubes, and uricase enzyme, showed remarkable analytical performances toward UA with high sensitivity (CO2H 418 μA μM−1 cm−2 and bare SPE-based biosensor, 33 μA μM−1 cm−2), low detection limits (CO2H 0.5 nM and bare SPE-based biosensors, 280 nM), and good repeatability (CO2H and bare SPE-based biosensors, 5% and 10%, respectively). Moreover, the reproducibility (RSD%) of these platforms in tests conducted for UA determination in buffer and urine samples results are equal to 6% and 15%, respectively. These results demonstrate that the nanoengineered electrode exhibited good selectivity and sensitivity toward UA even in the presence of interfering species, thus paving the way for its application in other bio-fluids such as simple point-of-care (POC) devices.

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An inverse-designed electrochemical platform for analytical applications

Cited by 14 publications

References 27 publications

Sensitive Detection of Industrial Pollutants Using Modified Electrochemical Platforms

Sensitive Detection of Industrial Pollutants Using Modified Electrochemical Platforms

Water-Phase Exfoliated Biochar Nanofibers from Eucalyptus Scraps for Electrode Modification and Conductive Film Fabrication

Powerful Electron-Transfer Screen-Printed Platforms as Biosensing Tools: The Case of Uric Acid Biosensor

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