An inulin-type fructan isolated from Serratula chinensis alleviated the dextran sulfate sodium-induced colitis in mice through regulation of intestinal barrier and gut microbiota

Li, Zhenwei; Wen, Qiuyi; Pi, Jiaju; Zhang, Daidi; Nie, J.; Wei, Wenlong; Li, Wei; Guo, De‐An

doi:10.1016/j.carbpol.2023.121206

Cited by 10 publications

(2 citation statements)

References 60 publications

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“…The mechanical barrier, primarily supported by tight junction proteins such as occludin and ZO-1, was crucial in preventing harmful substances and microorganisms from penetrating the mucosa. [19] When this barrier was damaged, a notable loss of tight junction proteins became the defining characteristic. The colonic tissue pathology was assessed using a grading scheme (Table S2).…”

Section: Effects Of Rlp On the Colon Structure And Intestinal Barrier...mentioning

confidence: 99%

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Peng,

Lu,

Lin

et al. 2024

Chemistry & Biodiversity

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Rosa laevigata Michx. polysaccharides (RLP) have been demonstrated to possess antioxidant and anti‐inflammatory properties. However, the mechanisms and efficacy of these polysaccharide components in preventing ulcerative colitis (UC) remain to be elucidated. The efficacy and mechanisms of RLP were investigated in a study that utilized healthy adult beagles to establish a UC model, considering the similarities in gut microbiota between humans and dogs. In the study, the beagle model induced by sodium dextran sulfate exhibited typical symptoms of ulcerative colitis, such as weight loss and diarrhea. All these symptoms and changes were significantly ameliorated through oral supplementation of RLP. Additionally, microbial community analysis based on the 16S rDNA gene revealed that RLP alleviated UC by increasing the abundance of beneficial bacteria and reducing the abundance of harmful bacteria. In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.

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Section: Effects Of Rlp On the Colon Structure And Intestinal Barrier...mentioning

confidence: 99%

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Peng,

Lu,

Lin

et al. 2024

Chemistry & Biodiversity

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“…Dietary supplementation inulin also attenuated age-related muscle loss in aged rats 12 . Inulin could exert beneficial anti-inflammatory effects through short-chain fatty acid metabolites fermented by gut microbiota 13 , and also alleviate intestinal inflammation by modulating the intestinal barrier and gut microbiota 14 . However, studies on the improvement in the gut microbiota of burn patients with inulin have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders

Gao,

Zhao,

Leng

et al. 2024

Sci Rep

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Inulin, as a prebiotic, could modulate the gut microbiota. Burn injury leads to gut microbiota disorders and skeletal muscle catabolism. Therefore, whether inulin can improve burn-induced muscle atrophy by regulating microbiota disorders remains unknown. This study aimed to clarify that inulin intake alleviates gut microbiota disorders and skeletal muscle atrophy in burned rats. Rats were divided into the sham group, burn group, prebiotic inulin intervention group, and pseudo-aseptic validation group. A 30% total body surface area (TBSA) third-degree burn wound on dorsal skin was evaluated in all groups except the sham group. Animals in the intervention group received 7 g/L inulin. Animals in the validation group received antibiotic cocktail and inulin treatment. In our study inulin intervention could significantly alleviate the burn-induced skeletal muscle mass decrease and skeletal myoblast cell apoptosis. Inulin intake increased the abundances of Firmicutes and Actinobacteria but decreased the abundance of Proteobacteria. The biosynthesis of amino acids was the most meaningful metabolic pathway distinguishing the inulin intervention group from the burn group, and further mechanistic studies have shown that inulin can promote the phosphorylation of the myogenesis-related proteins PI3K, AKT and P70S6K and activate PI3K/AKT signaling for protein synthesis. In conclusion, inulin alleviated burn induced muscle atrophy through PI3K/AKT signaling and regulated gut microbiota dysbiosis.

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Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive “polysaccharides‐bond‐bacteria‐enzyme” equation

Rong,

Shen,

Shu

2024

Phytotherapy Research

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Polysaccharides are one of the most important components of traditional Chinese medicine (TCM) and have been extensively studied for their immunomodulatory properties. The functions and effects of TCM polysaccharides are closely related to the gut microbiota, making the study of their interaction a hot topic in the field of TCM metabolism. This review follows two main inquiries: first, how the gut microbiota breaks down TCM polysaccharides to produce bioactive metabolites; and second, how TCM polysaccharides reshape the gut microbiota as a carbon source. Understanding the interaction mechanism involves a challenging equation of the structural association of TCM polysaccharides with the metabolic activities of the microbiota. This review has meticulously searched, partially organized literature spanning the past decade, that delves into the interaction mechanism between TCM polysaccharides and gut microbiota. It also gives an overview of the complex factors of the elusive “polysaccharides‐bond‐bacteria‐enzyme” equation: the complexity of polysaccharide structures, the diversity of glycosidic bond types, the communal nature of metabolizing microbiota, the enzymes involved in functional degradation by microbiota, and the hierarchical roles of polysaccharide utilization locus and gram‐positive PULs. Finally, this review aims to facilitate discussion among peers in the field of TCM microbiota and offers prospects for research in related fields, paving the way for pharmacological studies on TCM polysaccharides and gut microbiota therapeutics, and providing a reference point for further clinical research.

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An inulin-type fructan isolated from Serratula chinensis alleviated the dextran sulfate sodium-induced colitis in mice through regulation of intestinal barrier and gut microbiota

Cited by 10 publications

References 60 publications

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders

Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive “polysaccharides‐bond‐bacteria‐enzyme” equation

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