An Introduction to Bioreactor Hydrodynamics and Gas‐Liquid Mass Transfer

Kadic, Enes; Heindel, Theodore J.

doi:10.1002/9781118869703

Cited by 35 publications

(39 citation statements)

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“…Laminar flow regimes are typically associated with low speeds or highly viscous media, while turbulent flow regimes require high air flow rates to support the high oxygen demand [6,13]. However, the internal hydrodynamics depends on operating conditions.…”

Section: Introductionmentioning

confidence: 99%

Global performance parameters for different pneumatic bioreactors operating with water and glycerol solution: experimental data and CFD simulation

Rodriguez

Valverde-Ramírez

Mendes

et al. 2015

Bioprocess Biosyst Eng

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Global variables play a key role in evaluation of the performance of pneumatic bioreactors and provide criteria to assist in system selection and design. The purpose of this work was to use experimental data and computational fluid dynamics (CFD) simulations to determine the global performance parameters gas holdup ([Formula: see text]) and volumetric oxygen transfer coefficient (k L a), and conduct an analysis of liquid circulation velocity, for three different geometries of pneumatic bioreactors: bubble column, concentric-tube airlift, and split tube airlift. All the systems had 5 L working volumes and two Newtonian fluids of different viscosities were used in the experiments: distilled water and 10 cP glycerol solution. Considering the high oxygen demand in certain types of aerobic fermentations, the assays were carried out at high flow rates. In the present study, the performances of three pneumatic bioreactors with different geometries and operating with two different Newtonian fluids were compared. A new CFD modeling procedure was implemented, and the simulation results were compared with the experimental data. The findings indicated that the concentric-tube airlift design was the best choice in terms of both gas holdup and volumetric oxygen transfer coefficient. The CFD results for gas holdup were consistent with the experimental data, and indicated that k L a was strongly influenced by bubble diameter and shape.

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Section: Introductionmentioning

confidence: 99%

Global performance parameters for different pneumatic bioreactors operating with water and glycerol solution: experimental data and CFD simulation

Rodriguez

Valverde-Ramírez

Mendes

et al. 2015

Bioprocess Biosyst Eng

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“…For instance, addition of 42 (nano)particles in the media have been demonstrated to enhance 43 k L values by facilitating the transport of gas molecules into the bulk 44 liquid [12,13]. However, additives with potential toxicity in the 45 fermentation media could lead to cell damage, possibly interrupt-46 ing the cultivation of microorganism [14]. 47 Gas-liquid interfacial area ('a') could relatively easily be 48 increased by decreasing the bubble size [11].…”

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confidence: 99%

“…Certain additives 49 such as electrolytes have been known to inhibit bubble coales-50 cence, leading to smaller bubble size and enhanced gas-liquid 51 interfacial area [15]. However, high salt concentration could hinder 52 growth of microorganisms [14,16]. Although increasing impeller 53 speed could easily induce smaller bubble size by breaking bubbles, Polyvinylidine fluoride (PVDF) hollow fiber membranes were employed to enhance mass transfer rate of methane in water for the fermentation of Methylosinus trichosporium OB3b.…”

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confidence: 99%

“…The 14 development of shale gas, natural gas trapped within shale formation, 15 has accelerated the use of methane in industry [1,2]. Among various 16 processes utilizing methane as a major resource, biological conver-17 sion of methane into secondary product such as alcohol by 18 microorganism or enzyme has potential to be developed as cost- 19 effective, energy-efficient, and eco-friendly industrial process [3,4].…”

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confidence: 99%

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Enhanced mass transfer rate of methane via hollow fiber membrane modules for Methylosinus trichosporium OB3b fermentation

Lee

Jang

Yasin

et al. 2016

Journal of Industrial and Engineering Chemistry

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“…The airlift reactor is a class of pneumatic reactor that is designed to address the shortcomings found in the bubble column [1]. This device is attractive for its lower likelihood for mechanical failures, relatively lower shear rate in the absence of mechanical agitation and minimal loss of sterility [2].…”

Section: Introductionmentioning

confidence: 99%

Experimental measurement and CFD simulation on the hydrodynamics of an internal-loop airlift reactor

2017

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Abstract. This paper concerns with the experimental measurement and computational fluid dynamics simulation on local hydrodynamics of a gas-liquid internal-loop airlift reactor. The aim of this work is to study the sensitivity of the drag models and the significance of considering the lift force on the predictive accuracy of the simulation. The experimental analysis was carried out using laser Doppler anemometry at three different heights (i.e. Y = 0.20 m, 0.30 m and 0.38 m) across the riser and downcomer at volumetric flow rate of 0.30 m 3 /h to provide validation for the simulation results. A transient three-dimensional gasliquid internal-loop airlift reactor was carried out using FLUENT 16.2 by implementing the two-fluid model approach. The Eulerian-Eulerian multiphase and standard k-İ dispersed turbulence model were employed in this study. Results suggest that the spherical drag model performed poorly and that the drag model governed by Rayleigh-Taylor shows promising accuracy in the prediction of overall mean axial liquid velocity. On the other hand, the consideration of lift model shows slightly improvement in accuracy. These findings may serve as a guidance for future scale-up and design of airlift reactor studies

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An Introduction to Bioreactor Hydrodynamics and Gas‐Liquid Mass Transfer

Cited by 35 publications

References 0 publications

Global performance parameters for different pneumatic bioreactors operating with water and glycerol solution: experimental data and CFD simulation

Global performance parameters for different pneumatic bioreactors operating with water and glycerol solution: experimental data and CFD simulation

Enhanced mass transfer rate of methane via hollow fiber membrane modules for Methylosinus trichosporium OB3b fermentation

Experimental measurement and CFD simulation on the hydrodynamics of an internal-loop airlift reactor

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