An intrinsic connectivity network approach to insula-derived dysfunctions among cocaine users

Wisner, Krista; Patzelt, Edward H.; Lim, Kelvin O.; MacDonald, Angus W.

doi:10.3109/00952990.2013.848211

Cited by 48 publications

(51 citation statements)

References 88 publications

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“…Our findings add to mounting evidence that the insula plays a central role in addictive behavior (Cisler et al, 2013; Goldstein et al, 2009; McHugh et al, 2013; Naqvi et al, 2014; Noel et al, 2013a; Sutherland, McHugh, Pariyadath, & Stein, 2012; Viswanath et al, 2015; Volkow & Baler, 2015; Wisner, Patzelt, Lim, & MacDonald, 2013; Zhang et al, 2015), including cigarette addiction (Addicott et al, 2015; Clewett et al, 2014; Dinur-Klein et al, 2014; Forget, Pushparaj, & Le Foll, 2010; Gaznick, Tranel, McNutt, & Bechara, 2014; Janes et al, 2010; Naqvi et al, 2007; Suner-Soler et al, 2012; Zanchi et al, 2015). The link between the insula and addiction has largely been conceptualized as one that relates to the interoceptive functions commonly attributed to the region.…”

Section: Discussionsupporting

confidence: 75%

The first day is always the hardest: Functional connectivity during cue exposure and the ability to resist smoking in the initial hours of a quit attempt

et al. 2017

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Quitting smoking is the single best change in behavior that smokers can make to improve their health and extend their lives. Although most smokers express a strong desire to stop using cigarettes, the vast majority of quit attempts end in relapse. Relapse is particularly likely when smokers encounter cigarette cues. A striking number of relapses occur very quickly, with many occurring within as little as 24 hrs. Characterizing what distinguishes successful quit attempts from unsuccessful ones, particularly just after cessation is initiated, is a research priority. We addressed this significant issue by examining the association between functional connectivity during cigarette cue exposure and smoking behavior during the first 24 hrs of a quit attempt. Functional MRI was used to measure brain activity during cue exposure in nicotine-deprived daily smokers during the first day of a quit attempt. Participants were then given the opportunity to smoke. Using data collected in two parent studies, we identified a subset of participants who chose to smoke and a matched subset who declined (n = 38). Smokers who were able to resist smoking displayed significant functional connectivity between the left anterior insula and the dorsolateral prefrontal cortex, whereas there was no such connectivity for those who chose to smoke. Notably, there were no differences in mean levels of activation in brain regions of interest, underscoring the importance of assessing interregional connectivity when investigating the links between cue-related neural responses and overt behavior. To our knowledge, this is the first study to link patterns of functional connectivity and actual cigarette use during the pivotal first hours of attempt to change smoking behavior.

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Section: Discussionsupporting

confidence: 75%

The first day is always the hardest: Functional connectivity during cue exposure and the ability to resist smoking in the initial hours of a quit attempt

et al. 2017

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“…The group-level spatial maps were derived from resting-state scans of an independent community sample of 218 volunteers collected at the University of Minnesota (mean age = 26 years [range 20 to 39], 49% male) (Abram et al, 2015). Data were preprocessed using the following preprocessing steps in the MELODIC (Multivariate Exploratory Linear Optimized Decomposition into Independent Components) toolkit in FSL (http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/MELODIC): brain extraction, motion correction, and high-pass temporal filtering (threshold of 0.1 Hz) (Wisner, Patzelt, Lim, & MacDonald, 2013). As a final step, the data underwent motion regression outside of FSL using participant-specific movement parameters generated during registration (Moodie, Wisner, & MacDonald, 2014; Wisner, Atluri, Lim, & MacDonald, 2013).…”

Section: Methodsmentioning

confidence: 99%

“…More specifically, the MELODIC function in FSL was used to run 25 temporal concatenation (model-free and multi-subject) group-level pICAs. Each ICA included a random order of 80 participants as inputs to decrease the likelihood of over-fitting, with a dimensionality constraint of 60 based on reliability research (Poppe et al, 2013) and findings that large-scale networks, such as the DMN, fractionate at higher dimensionalities (Ray et al, 2013; Wisner, Atluri, et al, 2013; Wisner, Patzelt, et al, 2013). The 60 components from each ICA were merged into one file which was used as the input to a meta-level MELODIC (meta-ICA).…”

Section: Methodsmentioning

confidence: 99%

“…We calculated inter-network connectivity metrics between all group-level spatial maps using the participant-level timeseries data from the dual regression (Wisner, Patzelt, et al, 2013). These values were Pearson correlations between all pairs of participant-level timeseries (i.e., for all combinations of the 60 networks), and reflect the temporal association between network pairs.…”

Section: Methodsmentioning

confidence: 99%

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Default mode functional connectivity is associated with social functioning in schizophrenia.

Fox¹,

Abram²,

Reilly³

et al. 2017

Journal of Abnormal Psychology

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Individuals with schizophrenia display notable deficits in social functioning. Research indicates that neural connectivity within the default mode network (DMN) is related to social cognition and social functioning in healthy and clinical populations. However, the association between DMN connectivity, social cognition, and social functioning has not been studied in schizophrenia. For the present study, we used resting-state neuroimaging data to evaluate connectivity between the main DMN hubs (i.e., the medial prefrontal cortex (mPFC) and the posterior cingulate cortex-anterior precuneus (PPC)) in individuals with schizophrenia (n=28) and controls (n=32). We also examined whether DMN connectivity was associated with social functioning via social attainment (measured by the Specific Levels of Functioning Scale) and social competence (measured by the Social Skills Performance Assessment), and if social cognition mediates the association between DMN connectivity and these measures of social functioning. Results revealed that DMN connectivity did not differ between individuals with schizophrenia and controls. However, connectivity between the mPFC and PCC hubs was significantly associated with social competence and social attainment in individuals with schizophrenia but not in controls as reflected by a significant group-by-connectivity interaction. Social cognition did not mediate the association between social functioning and DMN connectivity in individuals with schizophrenia. Our findings suggest that fronto-parietal DMN connectivity in particular may be differentially associated with social functioning in schizophrenia and controls. As a result, DMN connectivity may be used as a neuroimaging marker to monitor treatment response or as a potential target for interventions that aim to enhance social functioning in schizophrenia.

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“…Thus, the connectivity within the insula, inferior frontal lobe, and DLPFC has been suggested as involving a cognitive control network [15] . Further, the inter-network connectivity involving the insula has been reported to be weaker in cocaine users and related to their impulsivity [16] . The insular-striatal connection also mediates the association between impulsivity and cocaine relapse [17] .…”

Section: The Insula and Addictionmentioning

confidence: 99%

Altered Functional Connectivity of the Insula and Nucleus Accumbens in Internet Gaming Disorder: A Resting State fMRI Study

Chen¹,

Yen

Wang

et al. 2016

Eur Addict Res

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Aims: A possible addiction mechanism has been represented by altered functional connectivity (FC) in the resting state. The aim of this study was to evaluate the FCs of the insula and nucleus accumbens among subjects with Internet gaming disorder (IGD). Methods: We recruited 30 males with IGD and 30 controls and evaluated their FC using functional magnetic imaging scanning under resting, a state with relaxation, closed eyes, with inducement to think of nothing systematically, become motionless, and instructed not to fall asleep. Results: Subjects with IGD had a lower FC with the left insula over the left dorsolateral prefrontal cortex (DLPFC) and orbital frontal lobe and a higher FC with the insula with the contralateral insula than controls. The inter-hemispheric insula connectivity positively correlated with impulsivity. Further, they had lower FC with the left nucleus accumbens over the left DLPFC and with the right nucleus accumbens over the left DLPFC, and insula and a higher FC with that over the right precuneus. Conclusion: The elevated inter-hemispheric insula FC is found to be associated with impulsivity and might explain why it is involved in IGD. The attenuated frontostriatal suggests that the emotion-driven gaming urge through nucleus accumbens could not be well regulated by the frontal lobe of subjects with IGD.

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An intrinsic connectivity network approach to insula-derived dysfunctions among cocaine users

Abstract: Aberrant insula-derived intrinsic connectivity patterns are observed in cocaine users and include dysfunctions in insula to striatal connectivity, which is furthermore linked to increased impulsivity pertaining to forethought.

Cited by 48 publications

References 88 publications

The first day is always the hardest: Functional connectivity during cue exposure and the ability to resist smoking in the initial hours of a quit attempt

The first day is always the hardest: Functional connectivity during cue exposure and the ability to resist smoking in the initial hours of a quit attempt

Default mode functional connectivity is associated with social functioning in schizophrenia.

Altered Functional Connectivity of the Insula and Nucleus Accumbens in Internet Gaming Disorder: A Resting State fMRI Study

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