An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey

Reece, Albert Stuart

doi:10.1038/sj.bdj.2008.932

Cited by 11 publications

(7 citation statements)

References 97 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…And the subject is of even more interest now in view of the enquiries from interested ADJ readers; the increasing place of illicit drugs of addiction in youth culture worldwide particularly in nations such as the Netherlands, the UK, and many parts of the USA in the years since this publication; an increasing interest in the connection between dental and systemic disease in relation to atherosclerotic disease, 2,3 schizophrenia 4 and dementia; 5 and in particular in view of the demonstration from this clinic that there is a statistical association between simple indices of dental and important psychological disorders. 6 Moreover, the statistical sophistication of this group has increased since the earlier report was made. For this reason it was felt useful and informative to provide further detail in regard to the earlier report relating to illicit drugs of addiction to dental pathology inboth substance dependent patients and non-addicted controls 1 and to extend the findings of that report.…”

mentioning

confidence: 99%

Dental Health In Addiction

Reece¹

2009

Australian Dental Journal

View full text Add to dashboard Cite

If we are wrong, then there may well be an increase in the incidence of gingivitis (but possibly not periodontitis; neither of which is deadly) and we will look a little bit silly! If we are correct, then there is likely to be a decreased incidence of oral cancer in the Australian public. We both feel comfortable with either of these scenarios and do not believe we are voicing our suspicions prematurely. REFERENCES

show abstract

mentioning

confidence: 99%

Dental Health In Addiction

Reece¹

2009

Australian Dental Journal

View full text Add to dashboard Cite

show abstract

“…These patients were 1,112 (69.37%) and 1,554 (54.39%) male, respectively (χ 2 = 95.80, P < 0.0001). Druguse data from this cohort have been previously published (Reece, 2007b(Reece, , 2007c(Reece, , 2008a.…”

Section: Resultsmentioning

confidence: 99%

Manifold implications of forgotten hyperglycemia in clinical opiate dependence

Reece

2012

Drug and Chemical Toxicology

View full text Add to dashboard Cite

Both chronic opiate dependence and diabetes are widespread public health problems. The historically causal relationship between opiate pharmacology and hyperglycemia would appear to have fallen from current medical knowledge. The aims of this study were to assess the severity of hyperglycemia in our opiate substance use disorder (SUD) patient population and review its pathophysiological basis. A review was undertaken of our clinical pathology database, comparing SUD patients and general medical controls (NSUD). A total of 1,602 SUD patients were compared with 2,858 NSUD patients 15-50 years of age. Mean ages were 31.29 ± 7.40 and 31.55 ± 9.17 years, respectively (P = 0.42) and were 68.60 and 52.76% male (P < 0.0001). The glycosylated hemoglobin (HbA1c) level in diabetics was 8.14 ± 2.76 and 6.29 ± 1.88 (P = 0.0032). In a nested case-control subset, random glucose, HbA1c, and fructosamine levels were all significantly elevated (P < 0.05). Adjusted for age, the HbA1c level was elevated among the SUD group (P < 0.0001) the age at addiction interaction was also significant (P < 0.0001). Serum glucose, HbA1c, fructosamine, and microalbumin levels were shown to be biomarkers of age. At multiple regression analysis, interactions between age, addictive status, glycemia, and the inflammatory markers, ethrocyte sedimentation rate and C-reactive protein, were significant (P < 0.05). At age 50, diabetic SUD patients had a HbA1c of 8.31%, which was equivalent to that of NSUD patients at age 140.54 years, a 181.07% elevation. These results confirm that hyperglycemia is higher in both an absolute and an age-dependent sense among diabetic SUD patients. These results are consistent with an acceleration of age-related and degenerative pathologies in many tissues and therefore carry far-reaching implications for the safety of indefinite opiate maintenance.

show abstract

“…Während hier klinische Studien noch ausstehen, wird diese Hypothese bereits durch 1. Ergebnisse der Grundlagenforschung unterstützt: In einem Tiermodell für Parodontitis senkte die Plaqueentfernung deutlich die Stressantwort [21].…”

Section: Ido Produziert Kynurenine Die Im Nervensystem Wirksam Sindunclassified

Depression und Fatigue bei chronischer Entzündung – Welchen Einfluss haben zahnärztliche Maßnahmen?

Huesker¹

2014

ZWR

View full text Add to dashboard Cite

In Abh?ngigkeit der individuellen Suszeptibilit?t kann die Fremdstoffbelastung aus Zahnersatzmaterialien Trigger f?r chronische Entz?ndungen setzen, die von Symptomen aus dem depressiven Formenkreis begleitet werden. Dabei spielen Sensibilisierungen ebenso wie immuntoxische Reaktionen auf die im Mund freigesetzten Metalle, Kunststoffe und Einwei?zerfallsprodukte eine wichtige Rolle. Der Zusammenhang zwischen Depression, Fatigue und Entz?ndung ist auf die Wirkung inflammatorischer Zytokine und die Ver?nderung des Tryptophan-Serotonin-Stoffwechsels zur?ckzuf?hren. Die Identifizierung individuell relevanter Triggerfaktoren und deren Expositionsvermeidung ist daher gerade auch vor dem klinischen Hintergrund einer depressiven Symptomatik eine wichtige Aufgabe der ganzheitlichen Zahnmedizin.

show abstract

An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey

Cited by 11 publications

References 97 publications

Dental Health In Addiction

Dental Health In Addiction

Manifold implications of forgotten hyperglycemia in clinical opiate dependence

Depression und Fatigue bei chronischer Entzündung – Welchen Einfluss haben zahnärztliche Maßnahmen?

Contact Info

Product

Resources

About