An intraventricular meningioma and recurrent astrocytoma collision tumor: a case report and literature review

Abstract

BackgroundIntracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles.Case presentationHere, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors.ConclusionsWe conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells in the choroid plexus.

A rare intracranial tumor consisting of malignant anaplastic and papillary meningioma subtypes

“…[ 6 9 ] The pathogenesis of collision tumors has been hypothesized to be secondary to simple chance alone or by one tumor acting as an irritating agent for the local proliferation and growth of the other and factors such as surgical trauma, ionizing radiation, and genetic predisposition have been associated with these tumors. [ 6 16 23 ] In our case, the patient had no prior history of cranial surgery or radiotherapy making the hypothesis of local proliferative factors of each tumor stimulating the growth of the other or genetic predisposition the most likely causes.…”

De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited

“…The development of two or more distinct types of brain tumors is a rare phenomenon associated mostly with radiation exposure or phakomatosis [ 10 , 11 ]. However, there are scattered reports describing the co-occurrence of two or more histologically different tumors in patients who were not exposed to radiation, nor had phakomatosis [ 2 , 12 , 13 ]. The most commonly reported association is the co-occurrence of meningioma and glioblastoma [ 2 ].…”

“…The most commonly reported association is the co-occurrence of meningioma and glioblastoma [ 2 ]. The majority of these reports describe a collision where the two tumors co-exist in a single primary lesion or close proximity [ 2 , 13 ], while cases where the two tumors are located in totally different sites are less frequently reported [ 14 , 15 ].…”

“…Our case presents a unique situation where the patient developed a glioblastoma on the background of a residual meningioma and an ischemic infarction. To our knowledge, this is the first report describing such a case, and we postulate, as Zhang et al have hypothesized, that the development of meningioma and glioma collision tumor is a dynamic process, where one type occurs after the other [ 13 ]. Our case together with other reported cases where the two tumors have not appeared at the same time might add further support to this hypothesis of dynamic development [ 2 , 4 ].…”

Collision occurrence of meningioma and astrocytoma: A case report and literature review

“…[1] However, the simultaneous development of these tumors at adjacent sites in the same patient without a history of radiotherapy or phakomatosis is extremely rare. [23456] The exact pathogenesis of this condition is still in controversies. Here, we present a case of collision tumors composed of a low-grade glioma and a meningioma.…”