An intraoperative fluorescent imaging system in organ transplantation

Sekijima, M.; Tojimbara, Tamotsu; Sato, Shuichi; Nakamura, Michio; Kawase, Tateo; Kai, Kotaro; Urashima, Y.; Nakajima, Ichiro; Fuchinoue, S; Teraoka, Satoshi

doi:10.1016/j.transproceed.2004.09.001

Cited by 100 publications

(74 citation statements)

References 2 publications

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“…Their studies showed the ability to assess vascular function after vein ligation, vein stripping, and phlebectomy. Intraoperatively, intravenous administration of ICG and fluorescence imaging has been employed to assess patency of arterial grafts [54][55][56][57] and of transplanted organs [58]. In addition, ICG fluorescence has been used in fluorescence angiography to visualize arteriovenous malformations during surgical repair [59].…”

Section: Vascular Repairmentioning

confidence: 99%

Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update~!2009-12-07~!2009-12-23~!2010-05-26~!

Marshall¹,

Rasmussen²,

Tan³

et al. 2010

TOSOJ

247

117

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Near-infrared (NIR) fluorescence imaging clinical studies have been reported in the literature with six different devices that employ various doses of indocyanine green (ICG) as a non-specific contrast agent. To date, clinical applications range from (i) angiography, intraoperative assessment of vessel patency, and tumor/metastasis delineation following intravenous administration of ICG, and (ii) imaging lymphatic architecture and function following subcutaneous and intradermal ICG administration. In the latter case, NIR fluorescence imaging may enable new discoveries associated with lymphatic function due to (i) a unique niche that is not met by any other conventional imaging technology and (ii) its exquisite sensitivity enabling high spatial and temporal resolution. Herein, we (i) review the basics of clinical NIR fluorescence imaging, (ii) survey the literature on clinical application of investigational devices using ICG fluorescent contrast, (iii) provide an update of non-invasive dynamic lymphatic imaging conducted with our FDPM device, and finally, (iv) comment on the future NIR fluorescence imaging for non-invasive and intraoperative use given recent demonstrations showing capabilities for imaging following microdose administration of contrast agent.

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Section: Vascular Repairmentioning

confidence: 99%

Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update~!2009-12-07~!2009-12-23~!2010-05-26~!

Marshall¹,

Rasmussen²,

Tan³

et al. 2010

TOSOJ

247

117

View full text Add to dashboard Cite

show abstract

“…2 While some research groups have investigated its use as a far-red fluorophore, 29 the low fluorescence yield and lack of any functional groups for addition of ligands have limited its use in clinical applications. ICG is the only approved fluorophore in the NIR-window and several imagers have been designed and commercially launched to allow ICG guidance in surgery for blood flow assessment, [30][31][32] hepatic function assessment, 33,34 and vessel patency and perfusion evaluation especially in reconstructive 35,36 and bypass surgeries. 37,38 The low tissue autofluorescence in the NIR-wavelengths further simplifies the task of filtering out background signals, and since ICG is the primary reimbursable agent today, almost all imaging device companies have built systems specifically for ICG imaging.…”

Section: Introductionmentioning

confidence: 99%

Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging

et al. 2016

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Abstract. There is growing interest in using fluorescence imaging instruments to guide surgery, and the leading options for open-field imaging are reviewed here. While the clinical fluorescence-guided surgery (FGS) field has been focused predominantly on indocyanine green (ICG) imaging, there is accelerated development of more specific molecular tracers. These agents should help advance new indications for which FGS presents a paradigm shift in how molecular information is provided for resection decisions. There has been a steady growth in commercially marketed FGS systems, each with their own differentiated performance characteristics and specifications. A set of desirable criteria is presented to guide the evaluation of instruments, including: (i) real-time overlay of white-light and fluorescence images, (ii) operation within ambient room lighting, (iii) nanomolar-level sensitivity, (iv) quantitative capabilities, (v) simultaneous multiple fluorophore imaging, and (vi) ergonomic utility for open surgery. In this review, United States Food and Drug Administration 510(k) cleared commercial systems and some leading premarket FGS research systems were evaluated to illustrate the continual increase in this performance feature base. Generally, the systems designed for ICG-only imaging have sufficient sensitivity to ICG, but a fraction of the other desired features listed above, with both lower sensitivity and dynamic range. In comparison, the emerging research systems targeted for use with molecular agents have unique capabilities that will be essential for successful clinical imaging studies with low-concentration agents or where superior rejection of ambient light is needed. There is no perfect imaging system, but the feature differences among them are important differentiators in their utility, as outlined in the data and tables here. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…[6][7][8] Fluorescence-assisted techniques have also been successfully applied to cardiovascular surgery procedures, organ transplantation, as well as controlled photothermal treatments. [9][10][11] All of these techniques require the use of optical probes that could act as contrast agents. Molecular probes, such as fluorescent proteins and dyes, have been extensively used for this purpose and some of them have been approved for clinical use.…”

Section: Introductionmentioning

confidence: 99%

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Rosal

Pérez‐Delgado

Misiak

et al. 2015

Journal of Applied Physics

107

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The spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF 3 :Nd 3þ , SrF 2 :Nd 3þ , NaGdF 4 : Nd 3þ , NaYF 4 : Nd 3þ , KYF 4 : Nd 3þ , GdVO 4 : Nd 3þ , and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a "universal" optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymiumdoped nanoparticle to be preferentially used in each case. V C 2015 AIP Publishing LLC.

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An intraoperative fluorescent imaging system in organ transplantation

Cited by 100 publications

References 2 publications

Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update~!2009-12-07~!2009-12-23~!2010-05-26~!

Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update~!2009-12-07~!2009-12-23~!2010-05-26~!

Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

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