An Intraoperative Beta Probe Dedicated to Glioma Surgery: Design and Feasibility Study

Bonzom, S.; Ménard, Laurent; Pitre, S.; Duval, M.; Siebert, R.; Palfi, Stéphane; Pinot, L.; Lefèbvre, F.; Charon, Y.

doi:10.1109/tns.2006.885574

Cited by 23 publications

(23 citation statements)

References 30 publications

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“…The design of the intraoperative -probe was previously described [34]. Briefly, it consists of an exchangeable detection head composed of eight elements held around the excision tool in a closed packed annular arrangement (Fig.…”

Section: A Design Of the Intraoperative -Probementioning

confidence: 99%

“…Each detection element made of 2 mm diameter clear and scintillating plastic fibers (BCF-12 and BCF-98 series, Bicron) is based on the association of a -sensitive fiber and a -shielded one to perform the subtraction of the 511 keV ray background. The previous study has shown that a -sensitive fiber with a 0.5 mm thick scintillating part exhibits the optimal properties in terms of electron energy deposition from F sources ( keV, keV) and minimal contamination from background rays [34]. The 2 mm length of the -shielded fiber was also optimized to reduce the statistical fluctuations in the measurement of the photon signal while minimizing the sensitivity of the subtraction method to the variation in the background distribution [34].…”

Section: A Design Of the Intraoperative -Probementioning

confidence: 99%

“…The previous study has shown that a -sensitive fiber with a 0.5 mm thick scintillating part exhibits the optimal properties in terms of electron energy deposition from F sources ( keV, keV) and minimal contamination from background rays [34]. The 2 mm length of the -shielded fiber was also optimized to reduce the statistical fluctuations in the measurement of the photon signal while minimizing the sensitivity of the subtraction method to the variation in the background distribution [34]. In practice, the thickness of the scintillating part of the fused fibers was controlled with an additional experimental setup (cf.…”

Section: A Design Of the Intraoperative -Probementioning

confidence: 99%

“…The absolute detection efficiency of the complete probe system was addressed by implementing an additional experimental setup previously described and based on a high gain photomultiplier tube and a triggering PMT [34]. The high gain PMT both measures the count rate detected by the detection element and the amount of light output calibrated in photoelectron number [34].…”

Section: ) Detection Efficiency and Uniformitymentioning

confidence: 99%

“…A proof of principle investigation based on Monte Carlo simulations and preliminary measurements validated the technical choice for the configuration of the intraoperative probe and defined the optimal detector geometry in terms of sensitivity, ray rejection efficiency and minimum detectable radiotracer concentration [34]. This paper describes the design and performance characterization of the first prototype we developed for in situ detection of -labeled brain tumor remnants.…”

Section: Introductionmentioning

confidence: 99%

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Physical Performance of an Intraoperative Beta Probe Dedicated to Glioma Radioguided Surgery

Bogalhas¹,

Ménard²,

Bonzom³

et al. 2008

IEEE Trans. Nucl. Sci.

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The precise delineation and excision of brain tumor extent allows to improve survival outcome and quality of life of surgically treated patients. In order to refine the resection of gliomas, we are developing a novel intraoperative probe specifically dedicated to the localization of residual tumor after the bulk has been excised. The probe, built around clear and plastic scintillating fibers, was designed to detect positrons emitted from radiolabeled brain tissue in order to discriminate more specifically neoplastic from normal tissues. The probe was also built to be directly coupled to the excision tool leading to simultaneous detection and removal of tumor. We report here performances of the first radio-isotopic configuration of the intraoperative probe which consists of a detection head composed of eight detection elements held around the excision tool in a closed packed annular arrangement. This head is coupled to an optic fiber bundle that exports the scintillating light to a multi-channel photomultiplier tube. The ray background generated by the annihilation of + in tissues is eliminated by a real-time subtraction method. The detector exhibits a sensitivity of 139 cps/kBq and a ray rejection efficiency of 99.5%. The ability of the probe to detect residual lesions was evaluated with a realistic brain phantom representing the surgical cavity and the boundaries of the tumor. We showed that lesions as small as 5 mm in diameter can be detected for tumor to normal tissue uptake ratios of fluorinated tracers greater than 3.5. This ratio is achieved with radiopharmaceuticals like 18 F-FET or 18 F-choline. These promising results suggest that the features of our system are compatible with in situ localization of residual radiolabeled tumors.

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Section: A Design Of the Intraoperative -Probementioning

confidence: 99%

Section: A Design Of the Intraoperative -Probementioning

confidence: 99%

Section: A Design Of the Intraoperative -Probementioning

confidence: 99%

Section: ) Detection Efficiency and Uniformitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical Performance of an Intraoperative Beta Probe Dedicated to Glioma Radioguided Surgery

Bogalhas¹,

Ménard²,

Bonzom³

et al. 2008

IEEE Trans. Nucl. Sci.

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Nuclear‐medicine probes: Where we are and where we are going

González-Montoro

Donoso²,

Konstantinou³

et al. 2022

Medical Physics

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Nuclear medicine probes turned into the key for the identification and precise location of sentinel lymph nodes and other occult lesions (i.e., tumors) by using the systemic administration of radiotracers. Intraoperative nuclear probes are key in the surgical management of some malignancies as well as in the determination of positive surgical margins, thus reducing the extent and potential surgery morbidity. Depending on their application, nuclear probes are classified into two main categories, namely, counting and imaging. Although counting probes present a simple design, are handheld (to be moved rapidly), and provide only acoustic signals when detecting radiation, imaging probes, also known as cameras, are more hardware‐complex and also able to provide images but at the cost of an increased intervention time as displacing the camera has to be done slowly. This review article begins with an introductory section to highlight the relevance of nuclear‐based probes and their components as well as the main differences between ionization‐ (semiconductor) and scintillation‐based probes. Then, the most significant performance parameters of the probe are reviewed (i.e., sensitivity, contrast, count rate capabilities, shielding, energy, and spatial resolution), as well as the different types of probes based on the target radiation nature, namely: gamma (γ), beta (β) (positron and electron), and Cherenkov. Various available intraoperative nuclear probes are finally compared in terms of performance to discuss the state‐of‐the‐art of nuclear medicine probes. The manuscript concludes by discussing the ideal probe design and the aspects to be considered when selecting nuclear‐medicine probes.

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Introduction to Radioguided Surgery

Collamati

2016

An Intraoperative Beta−Probe for Cancer Surgery

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An Intraoperative Beta Probe Dedicated to Glioma Surgery: Design and Feasibility Study

Cited by 23 publications

References 30 publications

Physical Performance of an Intraoperative Beta Probe Dedicated to Glioma Radioguided Surgery

Physical Performance of an Intraoperative Beta Probe Dedicated to Glioma Radioguided Surgery

Nuclear‐medicine probes: Where we are and where we are going

Introduction to Radioguided Surgery

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