An interview based approach to the anorectal portion of the International Standards of Neurological Classification of Spinal Cord Injury Exam (I-A-ISNCSCI): a pilot study

Chun, Audrey; Delgado, Andrew; Tsai, Chung‐Ying; Spielman, Lisa; Taylor, Kristell; Ramirez, Arianny; Huang, Vincent; Kolakowsky-Hayner, Stephanie A.; Escalón, Miguel X.; Bryce, Thomas N.

doi:10.1038/s41393-019-0399-5

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…The analysis reason was that the compression and invasion of spinal cord tumors in the lesion layer caused the destruction of fiber bundles and involved the white matter fibers at the distal end of the lesion, resulting in fine structural changes, while the upper layer of the lesion reflected the degree of anisotropy of normal spinal cord [ 18 ]. ISNCSCI score is a commonly used score to reflect the neurological function of spinal cord, which can be used to evaluate the neurological function of patients from the aspects of motor and sensation in detail [ 19 ]. The research shows that ADC in the lesion layer of patients with high cervical spinal cord tumor is negatively correlated with ISNCCSI score, while FA, FT, FTR1, and FTR2 are positively correlated with ISNCCSI score, which indicates that DTI parameters can reflect the spinal nerve function injury of patients.…”

Section: Discussionmentioning

confidence: 99%

The Value of DTI Parameters in Predicting Postoperative Spinal Cord Function Fluctuations in Patients with High Cervical Disc Tumors

Wang

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the characteristics of magnetic resonance diffusion tensor imaging (DTI) parameters in patients with high cervical spinal myeloma and the evaluation of postoperative spinal cord function. Methods. In recent years, 42 patients with high cervical spine myeloma were selected as the observation group, and 42 healthy volunteers were selected as the control group during the same period. The apparent dispersion coefficient (ADC), the fractional anisotropy (FA), the number of fiber bundles (FT), and the fiber bundle ratio (FTR) were compared between the two groups. The correlation between the ADC, FA, FT, FTR, and the International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) score in the observation group were analyzed. Spinal cord function was evaluated using the Japanese Orthopaedic Association Score (JOA). Logistic regression model was used to analyze the factors affecting the recovery of spinal cord function after surgery. The receiver operating characteristic curve (ROC) was used to analyze the value of ADC, FA, FT, FTR1, and FTR2 in predicting the recovery of spinal cord function. Results. The ADCs of the lesion layer and lower layer of the observation group were higher than the middle and lower layers of the control group, the FA and FT were lower than the middle and lower layers of the control group, and FTR1 and FTR2 were lower than those of the control group ( P < 0.05 ). The ADC of the lesion layer in the observation group was negatively correlated with ISNCSCI score, and the FA, FT, FTR1, FTR2, and ISNCSCI scores were positively correlated ( P < 0.05 ). Three months after the operation, JOA was used to evaluate the spinal cord function, which was excellent in 23 cases and poor in 19 cases. Logistic regression model analysis showed that after the ISNCSCI score was controlled, the increase in ADC and the decrease in FA, FT, FTR1, and FTR2 of the lesion layer were independent risk factors for poor postoperative body function recovery ( P < 0.05 ). ROC analysis showed that the combination of ADC, FA, FT, FTR1, and FTR2 of the lesion layer predicted the AUC of spinal cord functional recovery was 0.941, which was better than the single prediction ( P < 0.05 ). Conclusion. The abnormal DTI parameter values of patients with high cervical spinal myeloma can better reflect the lack of spinal cord function, and they can effectively predict the recovery of the patient’s body function after surgery, providing a reference for clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

The Value of DTI Parameters in Predicting Postoperative Spinal Cord Function Fluctuations in Patients with High Cervical Disc Tumors

Wang

2022

Computational and Mathematical Methods in Medicine

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“…Due to the complexity of the mechanism underlying SCI, it is difficult to quantitatively evaluate the degree of nerve injury in clinical practice, and this challenge hinders SCI research. At present, clinical assessment of SCI severity and prediction of long-term neurological function recovery are mainly based on functional examination according to the International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) and the American Spinal Injury Association (ASIA) scale (AIS) [ 3 ]. However, in clinical settings, these assessments largely rely on doctors to make judgments on the basis of their clinical experience and are highly subjective and unreliable; therefore, their clinical application has certain limitations [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Steroid inhibited Serpina3n expression which was positively correlated with the degrees of spinal cord injury

Chen,

Wu,

Zhang

et al. 2024

Heliyon

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“…However, early MRI is not always suitable or accessible in patients with unstable SCIs (Wang et al, 2018;Albayar et al, 2019;Seif et al, 2019). Regarding physical examination, although the International Standards for Neurological Classification of Spinal Cord Injury examination is generally considered as the gold standard and is widely applied for the assessment of SCI severity and prognosis (Hales et al, 2015;Chun et al, 2020), this relatively subjective evaluation has certain limitations associated with its time-consuming nature and the need for patient cooperation, which is not applicable to patients in a state of coma, sedation, or spinal shock (Thomas and Murphy, 2018).…”

Section: Introductionmentioning

confidence: 99%

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

Wang

Wei

et al. 2022

Neural Regen Res

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Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI diagnosis and treatment. This paper reviews the research progress and application prospects of recently identified SCI-related biomarkers. Many structural proteins, such as glial fibrillary acidic protein, S100-β, ubiquitin carboxy-terminal hydrolase-L1, neurofilament light, and tau protein were correlated with the diagnosis, American Spinal Injury Association Impairment Scale, and prognosis of SCI to different degrees. Inflammatory factors, including interleukin-6, interleukin-8, and tumor necrosis factor α, are also good biomarkers for the diagnosis of acute and chronic SCI, while non-coding RNAs (microRNAs and long non-coding RNAs) also show diagnostic potential for SCI. Trace elements (Mg, Se, Cu, Zn) have been shown to be related to motor recovery and can predict motor function after SCI, while humoral markers can reflect the pathophysiological changes after SCI. These factors have the advantages of low cost, convenient sampling, and ease of dynamic tracking, but are also associated with disadvantages, including diverse influencing factors and complex level changes. Although various proteins have been verified as potential biomarkers for SCI, more convincing evidence from large clinical and prospective studies is thus required to identify the most valuable diagnostic and prognostic biomarkers for SCI.

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An interview based approach to the anorectal portion of the International Standards of Neurological Classification of Spinal Cord Injury Exam (I-A-ISNCSCI): a pilot study

Cited by 4 publications

References 14 publications

The Value of DTI Parameters in Predicting Postoperative Spinal Cord Function Fluctuations in Patients with High Cervical Disc Tumors

The Value of DTI Parameters in Predicting Postoperative Spinal Cord Function Fluctuations in Patients with High Cervical Disc Tumors

Steroid inhibited Serpina3n expression which was positively correlated with the degrees of spinal cord injury

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

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