An Intervention to Improve Adherence and Management of Symptoms for Patients Prescribed Oral Chemotherapy Agents

Spoelstra, Sandra L.; Given, Barbara; Given, Charles W.; Grant, Marcia; Sikorskii, Alla; You, Mingxu; Decker, Veronica

doi:10.1097/ncc.0b013e3182551587

Cited by 98 publications

(113 citation statements)

References 21 publications

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“…Five of these studies were randomized trials, none of which demonstrated significant differences between the intervention and control groups with respect to their primary adherence outcomes [44,45,47,52,54]. One randomized, three-arm trial did show differences in adherence, favoring the intervention groups, when the investigators conducted a post hoc pooled analysis comparing both interventions to the control group [47].…”

Section: Interventions To Improve Adherence To Oral Antineoplastic Thmentioning

confidence: 99%

“…In a total of 12 studies ( [44][45][46][47], treatment monitoring [48], pharmacy-based programs [42,49,50], counseling programs [51,52], prefilled pill boxes [53], and automated voice response systems [54]. Five of these studies were randomized trials, none of which demonstrated significant differences between the intervention and control groups with respect to their primary adherence outcomes [44,45,47,52,54].…”

Section: Interventions To Improve Adherence To Oral Antineoplastic Thmentioning

confidence: 99%

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A Systematic Review of Adherence to Oral Antineoplastic Therapies

et al. 2016

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Background. Oral antineoplastic therapies not only improve survival but also reduce the burden of care for patients. Yet patients and clinicians face new challenges in managing adherence to these oral therapies. We conducted a systematic literature review to assess rates and correlates of adherence to oral antineoplastic therapies and interventions aimed at improving adherence. Methods. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search of the Ovid MEDLINE database from January 1, 2003 to June 30, 2015, using relevant terminology for oral antineoplastic agents. We included observational, database, and intervention studies. At least two researchers evaluated each paper to ensure accuracy of results and determine risk of bias. Results. We identified 927 records from the search and screened 214 abstracts. After conducting a full-text review of 167

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Section: Interventions To Improve Adherence To Oral Antineoplastic Thmentioning

confidence: 99%

Section: Interventions To Improve Adherence To Oral Antineoplastic Thmentioning

confidence: 99%

A Systematic Review of Adherence to Oral Antineoplastic Therapies

et al. 2016

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“…Spoelstra ve ark. tarafından yapılan çalışmada otomatik ses yanıt sistemi olarak adlandırılan yöntemin oral kemoterapi alan hastalarda semptom yönetiminde ve hasta uyumunun değerlendirilmesinde kullanılabilir olduğu gösterilmiştir (17). Otomatik ses yanıt sistemi ise bilgisayar destekli olarak hastaların ihtiyaç duydukları konulara istedikleri zaman yanıt aldıkları bir sistemdir.…”

Section: Hasta Eğitimiunclassified

Key Element in Oral Chemotherapy: Patient Adherence

Sözeri¹,

Kutlutürkan²

2016

Van Med J

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“…Interventions that were standardized were more effective than those that were tailored (Conn et al 2009). An OA intervention study found CBT alone did not support improved self-management (Spoelstra et al 2013). Additionally, others have reported that a major barrier to self-management involves motivation (Possidente et al 2005), which may be needed for more complex or challenging health conditions like OA treatment for cancer patients.…”

Section: Introductionmentioning

confidence: 99%

“…However, patients are known to experience symptoms from side effects of treatment and miss as much as one-third of the prescribed OA doses required for treatment of the cancer (Spoelstra et al 2013, Bassan et al 2014, Puts et al 2014. Thus, a need exists to test interventions to train patients to self-manage when OAs are prescribed.…”

Section: Introductionmentioning

confidence: 99%

A trial examining an advanced practice nurse intervention to promote medication adherence and symptom management in adult cancer patients prescribed oral anti‐cancer agents: study protocol

Spoelstra

Burhenn

DeKoekkoek

et al. 2015

Journal of Advanced Nursing

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AimTo report a study protocol that refines then examines feasibility, preliminary efficacy, and satisfaction of ADHERE, an intervention using motivational interviewing and brief cognitive behavioral therapy as a mechanism for goal-oriented systematic patient education to promote symptom management and adherence among cancer patients prescribed oral anti-cancer agents. Background Cancer treatment with oral anti-cancer agents shifts responsibility for managing treatment from clinicians in supervised cancer centers to patients and their caregivers. Thus, a need exists to standardize start-of-care for support patient self-management of care at home. Design A two-phase quasi-experimental sequential design with repeated measures. Methods Sixty five adult patients newly prescribed an oral anti-cancer agent will be recruited from three community cancer centers. Phase one will enroll 5 patients to refine the ADHERE intervention prior to testing, using an iterative process. After completion, Phase two will enroll 30 patients who receive usual care to examine symptoms and ahderence. Advanced practice nurses will then be trained. Then 30 patients will be enrolled in the intervention group and provided ADHERE, a 4-week intervention using semi-structured interactions (initial face-to-face session and once a week phone sessions over 3-weeks) and a Toolkit to promote selfmanagement of care. Outcome measures include: oral anti-cancer agents adherence rate, symptom presence and severity, feasibility, and satisfaction with ADHERE. This protocol was approved January 2014 and is registered at ClinicalTrials.gov (Identifier NCT02337296). Discussion This nurse-led intervention has the potential to standardize the start-of-care trainingfor the patients to self-manage when prescribed oral anti-cancer agents for treatment. Summary Statement Why this study is needed? No standard of care exists for patients newly prescribed oral anti-cancer agents.  Many cancer patients treated with oral anti-cancer agents have difficulty managing symptoms, which may lead to adverse events and difficulty adhering to the medication regimen.  Sub-optimal adherence rates for cancer patients prescribed oral anti-cancer agents exist, which may impact cancer treatment effectiveness.

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An Intervention to Improve Adherence and Management of Symptoms for Patients Prescribed Oral Chemotherapy Agents

Cited by 98 publications

References 21 publications

A Systematic Review of Adherence to Oral Antineoplastic Therapies

A Systematic Review of Adherence to Oral Antineoplastic Therapies

Key Element in Oral Chemotherapy: Patient Adherence

A trial examining an advanced practice nurse intervention to promote medication adherence and symptom management in adult cancer patients prescribed oral anti‐cancer agents: study protocol

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