1996
DOI: 10.1007/bf02660884
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An interpretation of14C-urea and14C-primidone extraction in isolated rabbit lungs

Abstract: We measured the venous concentration versus time curves of 14C-urea and 14C-primidone after rapid bolus injections of a vascular reference indicator, fluorescein isothiocyanate dextran, and one of the two 14C-labeled indicators in isolated rabbit lungs perfused with Krebs-Ringer bicarbonate solution containing 4.5% bovine serum albumin at flow rates (F) of 6.67, 3.33, 1.67, and 0.83 ml/sec and with nearly constant microvascular pressure and total lung vascular volume. When we calculated the permeability-surfac… Show more

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Cited by 13 publications
(32 citation statements)
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“…The experiments were performed by using an isolated rabbit lung preparation, as previously described (1,2,5). New Zealand White rabbits of either sex were given chlorpromazine hydrochloride (25 mg/kg im), followed by pentobarbital sodium (20-25 mg/kg) via an ear vein, and then were heparinized (1,200 IU/kg) and exsanguinated via a carotid artery catheter.…”
Section: Animal Preparation (Isolated Rabbit Lung)mentioning
confidence: 99%
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“…The experiments were performed by using an isolated rabbit lung preparation, as previously described (1,2,5). New Zealand White rabbits of either sex were given chlorpromazine hydrochloride (25 mg/kg im), followed by pentobarbital sodium (20-25 mg/kg) via an ear vein, and then were heparinized (1,200 IU/kg) and exsanguinated via a carotid artery catheter.…”
Section: Animal Preparation (Isolated Rabbit Lung)mentioning
confidence: 99%
“…The pulmonary artery, vein, and trachea were cannulated, and a ligature was secured around the ventricles. The lungs were removed from the chest and attached to the perfusion system primed with a perfusate containing a PSS (in g/l: 0.35 KCl, 0.37 CaCl 2 ·2H 2 O, 0.29 MgSO 4 ·7H 2 O, 0.16 KH 2 PO 4 , 6.9 NaCl, 1 glucose, and 2.1 NaHCO 3 ) with 45 g/l of BSA (1,2,5). The perfusion system included a heated perfusate reservoir and a Master Flex roller pump, which pumped perfusate at a constant mean flow of 3.33 ml/s from the reservoir into the pulmonary artery, with the left atrial pressure set equal to atmospheric (pleural) pressure by adjusting the height of the venous outflow into the recirculation reservoir.…”
Section: Animal Preparation (Isolated Rabbit Lung)mentioning
confidence: 99%
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“…For example, Audi et al 1,2 have noted that the Crone-Renkin model and other axially distributed descriptions of tracer transport may lead to variations in estimates of parameters (such as permeability) with flow. A comparison of the behavior of an alternative model (our three-dimensional network model) to that of axial-distributed models, provides new insight into this issue.…”
Section: Introductionmentioning
confidence: 99%
“…(1), which is derived in Appendix A, (1) Here, D is the extravascular intratissue radial molecular diffusion coefficient, R o is the outer radius of the effective extravascular Krogh cylinder, R i is the inner radius, L is the length of the tissue cylinder, and ρ is the density of the tissue in g ml −1 . Using D = 1 × 10 −5 cm 2 s −1 , ρ = 1.0 g ml −1 , R i = 3.5 μm, and R o = 15 μm, one obtains an estimate of PS=500 ml min −1 g −1 .…”
Section: Introductionmentioning
confidence: 99%