An interpenetrated bioactive nonlinear optical MOF containing a coordinated quinolone-like drug and Zn(ii) for pH-responsive release

Abstract

A new interpenetrated bioactive nonlinear optical metal-organic framework [Zn2(ppa)2(1,3-bdc)(H2O)] has been designed and synthesized, which shows both a high drug content of 63.9% and a good slow release effect in simulated physical conditions compared to other non-interpenetrated bioactive MOFs. It also shows a large powder second-harmonic generation (SHG) efficiency of 5.6 times that of KH2PO4 (particle size: 150-200 μm).

Outlook on the Application of Metal-Liganded Bioactives for Stimuli-Responsive Release

“…The latter design is due to the fact that the interpenetrated metal-liganded bioactive bonds allow for slower release of the bioactive in physiological media [ 2 ]. An example of this behavior was observed for a novel MOF, with formula [Zn 2 (ppa) 2 (1,3-bdc)(H 2 O)]·2H 2 O, where ppa = pipemidic acid (bioactive), and bdc = 1,3-benzenedicarboxylate (low toxic ancillary ligand) [ 26 ] ( Figure 1 ). The ambidentate nature of pipemidic acid and bidentate properties of bdc are the structural building blocks for the generation of the MOF ( Figure 1 a–c) The corresponding in vitro release kinetics of Hppa from the MOF with particle size distribution of 25–40 μm was recorded in simulated gastric fluid (SGF, pH = 2), body fluid (SBF, pH = 7.4) and intestinum crassum fluid (SIC, pH = 8.3), respectively ( Figure 1 d).…”

“… ( a , b ) Graphical representation based on X-ray single-crystal diffraction data of complexation between Zn ions (green), with O donor in Hppa, O donors in bdc (red) with another Zn ion with N donor in Hppa (blue); ( c ) The structure of the MOF resembles a 2D interpenetrated network with 6-membered rings; ( d ) Reported release profile of Hppa from MOF. Reproduced with permission from the Royal Society of Chemistry [ 26 ]. …”

Smart Approach for In Situ One‐Step Encapsulation and Controlled Delivery of a Chemotherapeutic Drug using Metal–Organic Framework–Drug Composites in Aqueous Media

“…There are several reports that describe successful encapsulation and release of different small molecules (e.g. caffeine) from MOFs under the control of different triggering agents . Our group recently studied encapsulation and controlled release of dox from zeolitic imidazole frameworks under different external stimuli …”

“…caffeine) from MOFs under the control of different triggering agents. [15,[52][53][54][55][56][57] Our group recently studied encapsulation and controlled release of dox from zeolitic imidazole frameworks under different externals timuli. [58] In this study,w ei nvestigated the effect of pH change on drug release.…”

H3PW12O40 encapsulation by nanoporous metal organic framework HKUST-1: Synthesis, characterization, activity and stability

“…[1][2][3][4] The crystalline, porous structure in combination with huge surface area and pore volumes results in unique properties of these materials such as large porosity, high surface area, open metal centers, abundant aromatic ligands and ease of synthesis 2,[5][6][7][8][9][10] Up to now, several reactions have been carried out using MOFs as solid Lewis acid catalysts or catalyst supports but MOF materials usually do not possess Brönsted acidity, therefore some attempts have been made to introduce such functionality into them. 11 Recently, the use of conventional nano-metal functionality in combination with acidic supports such as Al 2 O 3 and MOFs supports investigated in recent years [12][13][14][15][16] Heteropoly acids (HPAs) can act as excellent acid, redox, and bi-functional catalysts in a variety of synthetically useful selective transformations of organic substances, due to their strong Brönsted acidity and fast reversible multi-electron redox transformation activities.…”