An International Pilot Study of CNV in Mental Illness

Timsit‐Berthier, M.; Gerono, A.; Rousseau, Jean-Charles; Mantanus, H.; Abraham, Péter; Verhey, F; Lamers, Th.B.; Emonds, P.

doi:10.1111/j.1749-6632.1984.tb23588.x

Cited by 20 publications

(8 citation statements)

References 5 publications

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“…All findings suggest that the changes in post-warning ERPs and CNV activity recorded in our presenile normal subjects, who showed no appreciable deficits in behavioral and mental performances, could be alerting signs of early brain involutional processes related to minimal and subclinical decline of stimulus orienting, attentiveness, short term memory function and response preparation capabilities. This particular bioelectric event has frequently been observed in the psychiatric population but is not specific to a single diagnoses, even if it appears to be a sensitive index of psychopathology, particularly of schizophrenia [1, 55,571, depression [56,58] and dementia [25,26]. In the PICD patients so far examined, the drastic CNV amplitude reduction was particularly accentuated in the frontal region, where indeed the mean WA3 was actually found to be positive.…”

Section: Cnv/rtmentioning

confidence: 90%

Cognitive event-related potentials and reaction time in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia

et al. 1990

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The so-called contingent negative variation (CNV) is a slow brain potential representing a complex of variously overlapped "endogenous" components of behavior related to different reasonably well-known neurocognitive processes. CNV complex evoked with a standard paradigm (S1-2 sec-S2-motor response) and reaction time (RT) to imperative signal (S2) were recorded and measured in 11 patients with initial presenile idiopathic cognitive decline (PICD), 8 with presenile Alzheimer-type dementia (PAD) and 10 healthy age-matched controls. Significant group differences were obtained for measures of some CNV components, particularly of the late pre-S2 CNV. No significant CNV activity, very prolonged RTs and sometimes characteristic post-imperative negative variation (PINV) were observed in the majority of patients with PAD. These results suggest that CNV complex and RT changes similar to those observed in our patients may constitute a valuable clue for the study of pathophysiological brain functioning in the early stages of presenile idiopathic mental deterioration.

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Section: Cnv/rtmentioning

confidence: 90%

Cognitive event-related potentials and reaction time in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia

et al. 1990

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“…The two challenge tests for each subject were separated by an interval of at least 5 days. All tests began at approximately 17.00 h. The CNV procedure has been described elsewhere (1,2,(21)(22). Briefly, the subjects sat in an upright position and pairs of tones (S1-S2) with moderate intensity were presented to them.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Aspirin on the CNV in Healthy Individuals

1995

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The effects of aspirin on the contingent negative variation (CNV) of 16 healthy, right-handed volunteers were studied in accordance with a placebo-controlled double-blind crossover design. Early and late CNV factors were measured. Aspirin caused a statistically significant decrease of the early wave and an increase of mean amplitude of the late wave. A central action of aspirin, affecting noradrenergic and dopaminergic structures, may be responsible for the CNV changes.

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“…The CNV recording procedure has been described previously in detail (Timsit-Berthier et al, 1984). Brie¯y, the CNV paradigm consisted of a warning stimulus (S1 : 1000 Hz, 50 ms tone) followed 1 s later by an imperative stimulus (S2 : 18 s light ashes) that the subject had to stop by pushing a button.…”

Section: Cnv Proceduresmentioning

confidence: 99%

“…Two components, probably coupled, have been reported in CNV: an early wave, maximal at the frontal cortex, and a late wave, maximal on the controlateral motor cortex of movement onset (BoÈ cker et al, 1990). In clinical routine, we used a CNV paradigm with a short interstimulus interval of 1 s duration, which is easier to record, but where the early and late components are mixed (Timsit-Berthier et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Influence of Diazepam on Contingent Negative Variation

Papart

Ansseau

Timsit‐Berthier³

1997

Hum. Psychopharmacol. Clin. Exp.

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Contingent Negative Variation (CNV) is an event-related potential that develops during a simple experimental situation associating a warning and an imperative stimuli. A neurochemical model of CNV has been recently proposed where CNV amplitude and duration are mediated by cholinergic neurons, themselves stimulated by catecholaminergic neurons and inhibited by GABAergic mechanisms. To test this inhibitory in¯uence of GABAergic mechanisms on CNV amplitude, we recorded CNV and spectral analysis in 10 depressed patients before and after 4 weeks of treatment with diazepam (30±45 mg/day) which potentiates GABAergic transmission. The results showed a signi®cant decrease of CNV amplitude after diazepam (from À12Á4 mV+ 8Á0 to À4Á5 mV+9Á8, t À3Á4, p`0Á01). This modi®cation did not depend on changes in depressive symptomatology as assessed by the Hamilton depression scale or on changes in the level of arousal, as evaluated by spectral analysis. Therefore, these results support our hypothesis of a speci®c GABA inhibitory tone in the genesis of CNV.

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An International Pilot Study of CNV in Mental Illness

Cited by 20 publications

References 5 publications

Cognitive event-related potentials and reaction time in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia

Cognitive event-related potentials and reaction time in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia

The Effects of Aspirin on the CNV in Healthy Individuals

Influence of Diazepam on Contingent Negative Variation

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