An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol

Rodd, Helen; Nazzal, Hani; Bonifácio, Clarissa Calil; Ruth, Choe Wei; Crombie, Felicity; Shahawy, Osama El; Foláyan, Morẹ́nikẹ́ Oluwátóyìn; Gambetta-Tessini, Karla; Goyal, Ashima; Hasmun, Noren; Issa, Ahmad I.; Jundi, Suhad; Manton, David J.; Narasimhan, S.; Omar, Samah I.; Parekh, Susan; Popoola, Bamidele Olubukola; Silva, Mihiri; Gd, Taylor; Naomi, Yang Qiyue

doi:10.3390/dj11050117

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Finally, it is worth mentioning a large-scale multicenter protocol currently being developed, involving 22 research groups from 15 countries located on all continents [49]. The objective is to investigate possible associations of MIH with other dental developmental anomalies, in different geographical locations.…”

Section: Discussionmentioning

confidence: 99%

Potential Association of Molar-Incisor Hypomineralization (MIH) with Dental Agenesis and Infraoccluded Deciduous Molars: Is MIH Related to Dental Anomaly Pattern (DAP)? An Observational Cross-Sectional Study

Marcianes,

Garcia-Camba,

Albaladejo

et al. 2024

JCM

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Background: Dental Anomaly Pattern (DAP) is a collection of morphologic, numeric, and eruptive anomalies of teeth that are often observed together, suggesting a potential genetic relationship. Our objective was to assess the potential associations of Molar-Incisor Hypomineralization (MIH), a common developmental defect of enamel mineralization with a controversial etiology, with two specific components of DAP: (1) agenesis (AG) and (2) infraoccluded deciduous molars (IODM). Establishing such an association between MIH and one or both anomalies would provide evidence supporting a genetic link between MIH and DAP. Methods: We examined pretreatment intraoral standardized photographies and panoramic radiographs from 574 children aged 8–14 years, 287 having MIH and 287 without MIH, comparing the frequencies of AG and IODM in both groups. The subject samples were sourced from the databases of the orthodontic department at a university hospital. Results: The frequencies of AG in the MIH and non-MIH groups were 7% and 8%, respectively (p = 0.751). The corresponding frequencies of IODM were 27% and 19.2%, respectively (p = 0.082). That is, children with MIH did not exhibit an increased frequency of AG or IODM compared to those without MIH. Conclusions: These findings do not support the inclusion of MIH in DAP. Nevertheless, further analysis of possible associations is necessary to definitively validate or invalidate this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Potential Association of Molar-Incisor Hypomineralization (MIH) with Dental Agenesis and Infraoccluded Deciduous Molars: Is MIH Related to Dental Anomaly Pattern (DAP)? An Observational Cross-Sectional Study

Marcianes,

Garcia-Camba,

Albaladejo

et al. 2024

JCM

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Association between molar–incisor hypomineralisation and dental anomalies

Fernandes,

Santos

2024

Int J Paed Dentistry

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BackgroundCommon etiological factors have been reported in the development of molar–incisor hypomineralisation (MIH) and dental anomalies (DA).AimTo assess the association between MIH and DAs.DesignA cross‐sectional study was performed to evaluate the presence of MIH and other six DAs in a sample of 415 pretreatment records from patients aged 9–18 years. Statistical analyses were performed using the chi‐squared and Fisher's exact tests, and logistic regressions.ResultsThere was statistically significant association between the prevalence of DAs and MIH (CI: 1.43–2.43, φ‐coefficient: 0.204, PR: 1.87). Higher percentage of tooth agenesis (CI: 1.37–1.68, φ‐coefficient: 0.271, PR: 1.50), maxillary premolar agenesis (CI: 1.70–3.65, φ‐coefficient: 0.125, PR: 2.49), mandibular second premolar agenesis (CI: 1.68–3.16, φ‐coefficient: 0.172, PR: 2.30) and distoangulation of the mandibular second premolars (CI: 1.31–3.47, φ‐coefficient: 0.103, PR: 2.13) was observed among children who had MIH‐affected teeth. Individuals with MIH had a 2.95 times greater chance of having DAs (R2 = .153). The number of patients with DAs was higher when the first molar showed severe defects (OR = 4.47; R2 = .149).ConclusionThere is a weak association between MIH and DAs. Patients with severe MIH lesions have a slightly higher risk of presenting DAs.

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An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol

Cited by 2 publications

References 19 publications

Potential Association of Molar-Incisor Hypomineralization (MIH) with Dental Agenesis and Infraoccluded Deciduous Molars: Is MIH Related to Dental Anomaly Pattern (DAP)? An Observational Cross-Sectional Study

Potential Association of Molar-Incisor Hypomineralization (MIH) with Dental Agenesis and Infraoccluded Deciduous Molars: Is MIH Related to Dental Anomaly Pattern (DAP)? An Observational Cross-Sectional Study

Association between molar–incisor hypomineralisation and dental anomalies

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