We report the epitaxial growth of a monoclinic VO 2 thin film on the CoFe 2 O 4 (111) template, assisted by an interfacial layer of the metastable orthorhombic phase. The interface between orthorhombic VO 2 and CoFe 2 O 4 is atomically sharp without noticeable interfacial diffusion. The (010)-faceted orthorhombic VO 2 layer is lattice-matched to both the CoFe 2 O 4 (111) template and the monoclinic phase, although they have different surface symmetries. The occurrence of an orthorhombic VO 2 thin layer significantly lowers the in-plane misfit strains of the monoclinic VO 2 epilayer, along both the [100] and [001] axes. Our first-principles calculations confirm that the low-misfit orthorhombic VO 2 is preferred on CoFe 2 O 4 (111) over the large-misfit monoclinic phase, at the initial growth stage. Additionally, upon increasing the film thickness to ∼8 nm, the orthorhombic phase is no longer favored, and the bulk stable monoclinic VO 2 appears to minimize the free energy of the system. Moreover, we show that the metal-to-insulator transition of our VO 2 epilayer can be efficiently triggered by both the temperature and Joule self-heating effect.