An interesting cause of esophageal ulcer etiology: Multiple myeloma of IgG kappa subtype

Abstract

Multiple myeloma is a neoplasm of mature and immature plasma cells. A 50-year-old woman with lumbago, dysphagia, and left arm pain was presented. Upper endoscopical examination was performed. There was an exudate-covered ulcer in the distal esophagus, located at 30-32 cm from the incisors, covering the whole mucosa. Histopathological examination of the specimens obtained from the lesion showed the involvement of plasma cells consistent with multiple myeloma of IgG kappa subtype. Esophageal involvement of multiple myeloma should be kept in mind in patients presenting with dysphagia.

Relapse of Multiple Myeloma Presenting as Extramedullary Plasmacytomas in Multiple Organs

“…Multiple myeloma (MM) is a neoplastic plasma cell disorder which usually presents as renal failure, anemia, hypercalcemia, lytic bone lesions, immunodeficiency, pathological fractures, and hyperviscosity. It constitutes 1% of all cancers and 10% of all hematological malignancies [ 1 – 3 ]. It usually occurs in the seventh or eighth decade of life [ 4 ].…”

Occult Esophageal Squamous Cell Carcinoma Presenting with Multiple Bony Osteolytic Lesions Clinically Mimicking Multiple Myeloma: A Diagnostic Dilemma

“…Calcemia, Renal dysfunction, unexplained Anemia, and Bone lytic lesions (CRAB). 10 There are reports of MM presenting with an esophageal ulcer. 10 The present case had features of end-organ damage like hypercalcemia, renal dysfunction, anemia, and bony lytic lesions, which led to the clinical suspicion of MM.…”

“…10 There are reports of MM presenting with an esophageal ulcer. 10 The present case had features of end-organ damage like hypercalcemia, renal dysfunction, anemia, and bony lytic lesions, which led to the clinical suspicion of MM. Bone marrow biopsy with negative monoclonal peak and urine Bence Jones protein helped in ruling out MM.…”

IgM‐ Kappa type multiple myeloma with simultaneous gastro‐esophageal involvement simulating linitis plastica

“…A previous treated patient of kappa-light chain multiple myeloma has been noted to have multilobulated submucosal mass with ulceration at the gastric body [2]. Pehlivan et al reported a rare endoscopic finding of exudate-covered ulcer in the distal esophagus in a 50-year-old woman with dysphagia and the biopsy result showed the involvement of plasma cells consistent with multiple myeloma of IgG kappa subtype [3].…”

“…Pehlivan et al. reported a rare endoscopic finding of exudate‐covered ulcer in the distal esophagus in a 50‐year‐old woman with dysphagia and the biopsy result showed the involvement of plasma cells consistent with multiple myeloma of IgG kappa subtype [3].…”