An interesting case of possible abscopal effect in malignant melanoma

Kingsley, D. P. E.

doi:10.1259/0007-1285-48-574-863

Cited by 151 publications

(78 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, ionizing radiation can achieve not only direct cancer cell death but also has an indirect and systemic anti-tumor mechanism outside of the irradiated field, which has been reported in some clinical settings (Antoniades, et al, 1977,Ehlers and Fridman, 1973,Kingsley, 1975,Nobler, 1969,Perego and Faravelli, 2000,Rees, 1981,Rees and Ross, 1983,Sham, 1995. Local irradiation resulted in an anti-tumor effect at a non-irradiated location in a patient with hepatocellular carcinoma that regressed after palliative local radiotherapy for pain control of bone metastases (Ohba, et al, 1998).…”

Section: Introductionmentioning

confidence: 94%

Abscopal Effect of Radiation Therapy: Current Concepts and Future Applications

Shiraishi¹

2012

Modern Practices in Radiation Therapy

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 94%

Abscopal Effect of Radiation Therapy: Current Concepts and Future Applications

Shiraishi¹

2012

Modern Practices in Radiation Therapy

View full text Add to dashboard Cite

“…79 A recent systematic review that included studies published between 1960 and 2014 identified 51 patients (23 case reports, 1 retrospective study; n 5 28) who reportedly had an abscopal effect. 80 Abscopal effects were observed a median of 5 months after RT (range, 1-24 months), with a median response duration of 13 months (range, 3-39 months).…”

Section: Reports Of the Abscopal Effectmentioning

confidence: 99%

Irradiation and immunotherapy: From concept to the clinic

Salama

Postow

Salama

2016

Cancer

View full text Add to dashboard Cite

In recent years, an increased understanding of T‐cell–regulatory mechanisms has led to the development of a novel class of immune‐checkpoint inhibitors that have robust clinical activity against a broad array of malignancies—even those that historically were not believed to be sensitive to immune therapy. With this, there has been renewed interest in the potential for synergy with more traditional forms of anticancer therapy like radiation therapy (RT). The role of RT in palliation or as definitive treatment for certain malignancies has been well established. Yet, in recent years, the concept has come to light that RT could be an attractive partner for use in combination with other immunotherapies. The effects of RT include not only control of an irradiated tumor but also multiple immunomodulatory effects on both the tumor and the microenvironment, priming tumors for an immune‐mediated response. Herein, the authors summarize relevant preclinical data and rationale supporting the synergy of combined RT and immunotherapy and highlight recent clinical work on promising combination strategies. Cancer 2016;122:1659‐71. © 2016 American Cancer Society.

show abstract

“…Brain metastases approximately 3 cm in diameter or less are ideal targets for SRS, owing to their spherical shape and relatively small size [10 • ]. Like surgery alone, SRS alone has shown little impact on extracranial metastasis control, though individual case reports have shown evidence of the abscopal effect, a phenomenon whereby localized irradiation to metastatic tumor causes shrinkage of tumor in sites far from the irradiated area [27][28][29]. Overall survival has also seen limited impact from SRS therapy [3,11] Rades et al [30] have reported that in RPA Class 1 and 2, SRS is more effective than WBRT alone regarding local tumor control, as measured by tumor size and recurrence.…”

Section: Stereotactic Radiosurgerymentioning

confidence: 99%

Management of Cerebral Brain Metastasis

2014

View full text Add to dashboard Cite

Brain metastasis is associated with a poor overall prognosis, but combination therapies have emerged that may prevent recurrence or serve as palliative therapies. There is a wide range of treatment options for those with 1-3 intracranial metastases and stable disease, including combinations of surgery, whole brain radiation therapy (WBRT), and stereotactic radiosurgery (SRS). Those with few, small metastases may be served well by SRS and adjuvant WBRT, whereas those with larger metastases that are amenable to resection may be treated with surgical excision and adjuvant WBRT. Whole brain radiation alone is reserved for individuals with greater than three brain metastases or unstable disease. A number of studies have been conducted to clarify the optimal treatment regimen for patients with varying intracranial disease. This review aims to synthesize the most current findings pertaining to the neurosurgical treatment of brain metastases.

show abstract

An interesting case of possible abscopal effect in malignant melanoma

Cited by 151 publications

References 7 publications

Abscopal Effect of Radiation Therapy: Current Concepts and Future Applications

Abscopal Effect of Radiation Therapy: Current Concepts and Future Applications

Irradiation and immunotherapy: From concept to the clinic

Management of Cerebral Brain Metastasis

Contact Info

Product

Resources

About