1975
DOI: 10.1259/0007-1285-48-574-863
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An interesting case of possible abscopal effect in malignant melanoma

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Cited by 151 publications
(78 citation statements)
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“…Thus, ionizing radiation can achieve not only direct cancer cell death but also has an indirect and systemic anti-tumor mechanism outside of the irradiated field, which has been reported in some clinical settings (Antoniades, et al, 1977,Ehlers and Fridman, 1973,Kingsley, 1975,Nobler, 1969,Perego and Faravelli, 2000,Rees, 1981,Rees and Ross, 1983,Sham, 1995. Local irradiation resulted in an anti-tumor effect at a non-irradiated location in a patient with hepatocellular carcinoma that regressed after palliative local radiotherapy for pain control of bone metastases (Ohba, et al, 1998).…”
Section: Introductionmentioning
confidence: 94%
“…Thus, ionizing radiation can achieve not only direct cancer cell death but also has an indirect and systemic anti-tumor mechanism outside of the irradiated field, which has been reported in some clinical settings (Antoniades, et al, 1977,Ehlers and Fridman, 1973,Kingsley, 1975,Nobler, 1969,Perego and Faravelli, 2000,Rees, 1981,Rees and Ross, 1983,Sham, 1995. Local irradiation resulted in an anti-tumor effect at a non-irradiated location in a patient with hepatocellular carcinoma that regressed after palliative local radiotherapy for pain control of bone metastases (Ohba, et al, 1998).…”
Section: Introductionmentioning
confidence: 94%
“…79 A recent systematic review that included studies published between 1960 and 2014 identified 51 patients (23 case reports, 1 retrospective study; n 5 28) who reportedly had an abscopal effect. 80 Abscopal effects were observed a median of 5 months after RT (range, 1-24 months), with a median response duration of 13 months (range, 3-39 months).…”
Section: Reports Of the Abscopal Effectmentioning
confidence: 99%
“…Brain metastases approximately 3 cm in diameter or less are ideal targets for SRS, owing to their spherical shape and relatively small size [10 • ]. Like surgery alone, SRS alone has shown little impact on extracranial metastasis control, though individual case reports have shown evidence of the abscopal effect, a phenomenon whereby localized irradiation to metastatic tumor causes shrinkage of tumor in sites far from the irradiated area [27][28][29]. Overall survival has also seen limited impact from SRS therapy [3,11] Rades et al [30] have reported that in RPA Class 1 and 2, SRS is more effective than WBRT alone regarding local tumor control, as measured by tumor size and recurrence.…”
Section: Stereotactic Radiosurgerymentioning
confidence: 99%