An interesting case of adenoviral hepatitis in a cardiac transplant recipient

Gupta, Alok; Philip, Alexander; Ranga, K. Vinay; Cappa, Joseph; Dougherty, James E.; Lawlor, Michael W.

doi:10.1111/j.1399-3062.2009.00471.x

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…reported adenoviral hepatitis in a cardiac transplant recipient (15). Abdominal CT scan showed multiple indeterminate low-attenuation masses in the liver.…”

Section: Discussionmentioning

confidence: 99%

Fulminant Hepatic Failure Caused by Adenovirus Infection Mimicking Peliosis Hepatitis on Abdominal Computed Tomography Images after Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2012

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Disseminated adenovirus disease after allogeneic hematopoietic stem cell transplantation (HSCT) is lethal in most cases, especially when it develops as fulminant hepatic failure. We encountered a patient who developed fulminant hepatic failure caused by adenovirus infection. She did not show manifestations of graftversus-host disease and the results of serum tests for viral infection were all negative. Abdominal computed tomography (CT) findings were consistent with peliosis hepatitis. She died of fulminant hepatic failure, however, and pathological examinations of the liver specimen obtained after her death revealed adenovirus infection. In this report, we review the clinical characteristics and imaging findings of fulminant hepatic failure caused by adenovirus infection.

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“…reported adenoviral hepatitis in a cardiac transplant recipient (15). Abdominal CT scan showed multiple indeterminate low-attenuation masses in the liver.…”

Section: Discussionmentioning

confidence: 99%

Fulminant Hepatic Failure Caused by Adenovirus Infection Mimicking Peliosis Hepatitis on Abdominal Computed Tomography Images after Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2012

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“…121 124 AdV infections have been seen principally in pediatric heart transplant recipients (HTRs) 203 226 ; in adult HTRs, serious AdV infections are limited primarily to case reports. 227 228 229 In pediatric HTRs, AdV has been observed in myocardial biopsies with or without necrosis or inflammation. 217 226 The presence of AdV in myocardial tissues increases the risk for graft loss and posttransplant coronary artery disease.…”

Section: Specific Patient Populations At Riskmentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Lynch

Kajon

2021

Semin Respir Crit Care Med

103

187

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Adenoviruses (AdVs) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or meningoencephalitis. AdV infections are more common in young children, due to lack of humoral immunity. Epidemics of AdV infection may occur in healthy children or adults in closed or crowded settings (particularly military recruits). The vast majority of cases are self-limited. However, the clinical spectrum is broad and fatalities may occur. Dissemination is more likely in patients with impaired immunity (e.g., organ transplant recipients, human immunodeficiency virus infection). Fatality rates for untreated severe AdV pneumonia or disseminated disease may exceed 50%. More than 100 genotypes and 52 serotypes of AdV have been identified and classified into seven species designated HAdV-A through -G. Different types display different tissue tropisms that correlate with clinical manifestations of infection. The predominant types circulating at a given time differ among countries or regions, and change over time. Transmission of novel strains between countries or across continents and replacement of dominant viruses by new strains may occur. Treatment of AdV infections is controversial, as prospective, randomized therapeutic trials have not been done. Cidofovir has been the drug of choice for severe AdV infections, but not all patients require treatment. Live oral vaccines are highly efficacious in reducing the risk of respiratory AdV infection and are in routine use in the military in the United States but currently are not available to civilians.

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“…8 Shirali et al 16 isolated mainly the serotype 2 from myocardial biopsies of their heart transplant recipients that developed adverse cardiac events. Few reports of adenovirus pneumonia, 18,19 hepatitis, 20 and disseminated disease have been published. 21 In heart transplantation, besides the invasive adenovirus disease which is similar to other solid organ transplants, the allograft can be affected indirectly.…”

Section: Epidemiologymentioning

confidence: 98%

Adenovirus Infections in Heart Transplantation

Florescu¹,

Kwon

Dumitru

2013

Cardiology in Review

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Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.

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An interesting case of adenoviral hepatitis in a cardiac transplant recipient

Cited by 10 publications

References 6 publications

Fulminant Hepatic Failure Caused by Adenovirus Infection Mimicking Peliosis Hepatitis on Abdominal Computed Tomography Images after Allogeneic Hematopoietic Stem Cell Transplantation

Fulminant Hepatic Failure Caused by Adenovirus Infection Mimicking Peliosis Hepatitis on Abdominal Computed Tomography Images after Allogeneic Hematopoietic Stem Cell Transplantation

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Adenovirus Infections in Heart Transplantation

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