An interesting bone scan in multiple myeloma—? myeloma superscan

Anscombe, Anthony R.; Walkden, S B

doi:10.1259/0007-1285-56-667-489

Cited by 10 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 34 case reports, malignancy was the cause of the superscan, and prostate cancer ( n = 15) was the most common cause, followed by gastric cancer ( n = 10). Other less common cancers that caused superscans included metastatic pheochromocytoma (Tan et al, 2015), paediatric neuroblastoma (Tripathi et al, 2015), intracranial glioma (Shinya et al, 2007), multiple myeloma (Anscombe & Walkden, 1983) and angiogenic myeloid metaplasia (Pour et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Frequency of superscan on bone scintigraphy: A systematic review

Kovacsne

Kozon

Bentestuen

2023

Clin Physio Funct Imaging

View full text Add to dashboard Cite

Introduction Bone scintigraphy (BS) is an important tool for detecting bone metastasis. BS with diffuse increased skeletal radioisotope uptake with absent or faint urinary tract and soft tissue activity is defined as a superscan. In this review, we investigate the different etiologies causing superscan and the reported frequency of superscan among different disease entities. Materials and Methods The search terms were ‘bone’ AND ‘superscan’ OR ‘superscan’ in the PubMed database from 1980 to November 2020. Eligibility criteria included the following: Peer‐reviewed studies containing original data using 99mTc‐phosphate‐analogue BS reporting a superscan pattern. Unretrievable papers, imaging modalities other than BS or with insufficient information to assess the aetiology were excluded. The abstracts of every paper and full texts of potentially eligible papers were assessed independently by three observers. Results Sixty‐seven papers were included (48 case reports and 19 cohort studies). Studies conducted in patients with osteomalacia or skeletal fluorosis revealed superscan in all patients. Other benign causes of superscan were hyperparathyroidism and kidney disease. Among papers with malignant cause, prostate cancer was the most common cause, followed by gastric cancer. The frequency of superscans ranged from 1.3% in a cohort of mixed cancer types up to 2.6% in patients with gastric cancer and up to 23% in a cohort of prostate cancer patients. Conclusion Superscan is most frequently seen in prostate cancer, but numerous other cancers and metabolic bone diseases can cause superscan, which should be kept in mind when encountering an unexpected superscan on BS.

show abstract

Section: Resultsmentioning

confidence: 99%

Frequency of superscan on bone scintigraphy: A systematic review

Kovacsne

Kozon

Bentestuen

2023

Clin Physio Funct Imaging

View full text Add to dashboard Cite

show abstract

“…That descriptive term in prostate, breast and lung metastases was followed by numerous publications describing superscan appearances in other clinical aetiologies -renal osteodystrophy [4], multiple myeloma [5], metabolic bone disease and lymphoma [6], gastric cancer [8] renal tubular acidosis [12], nasopharangeal carcinoma [13] and hyperparathyroidism [14]. The superscan findings are more frequently correlated with prostate cancer than with other conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Anscombe and Walkden [5] described a single case of superscan arising from multiple myeloma. Wilson et al [6] identified three distinctive patterns of superscan uptake: increased axial and appendicular uptake associated with metabolic bone disease; increased periarticular involvement of the appendicular skeleton found in patients with marrow proliferation including lymphoma; and the superscan of prostate carcinoma with raised axial skeleton uptake.…”

Section: Introductionmentioning

confidence: 99%

Technical note: identifying the prostate cancer ‘superscan’ by quantitative skeletal scintigraphy

Hawkins

Halewood

2008

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

“…Another reported scintigram appearance is the``superscan'', commonly associated with extensive metastatic or metabolic bone disease. The superscan shows prominent skeletal uptake of the radioisotope, with little or no radioisotope reaching the renal tract, leading to absent renal and delayed bladder demonstration [3]. Amyloidosis is often associated with MM as a result of light chain deposition within solid organs, blood vessels and connective tissues.…”

Section: Discussionmentioning

confidence: 99%

Extensive soft tissue uptake of 99Tcm methylene diphosphonate in a patient with multiple myeloma.

Evans

Murphy²,

Eyes³

2000

The British Journal of Radiology

View full text Add to dashboard Cite

Bone scintigraphy is not usually performed in multiple myeloma (MM), as marrow deposits characteristically show no tracer uptake. However, metastatic bone disease often mimics MM both clinically and biochemically, resulting in a substantial number of MM patients undergoing bone scintigraphy. Variable appearances in these cases have been reported, ranging from normal to a superscan, the latter a result of massive tracer uptake within bone. Soft tissue uptake has been documented, often when MM is complicated by secondary amyloidosis. This usually results in mainly solid organ uptake of tracer. We report a case of MM where massive soft tissue uptake occurred, primarily within muscles, with very little isotope elsewhere.

show abstract

An interesting bone scan in multiple myeloma—? myeloma superscan

Cited by 10 publications

References 8 publications

Frequency of superscan on bone scintigraphy: A systematic review

Frequency of superscan on bone scintigraphy: A systematic review

Technical note: identifying the prostate cancer ‘superscan’ by quantitative skeletal scintigraphy

Extensive soft tissue uptake of 99Tcm methylene diphosphonate in a patient with multiple myeloma.

Contact Info

Product

Resources

About