An interdigitated microelectrode based aptasensor for real-time and ultratrace detection of four organophosphorus pesticides

Zhang, Jian; Fang, Xiaobo; Cheng, Cheng; Hu, Zhiwen; Jiang, Yanting; Qi, Haochen; Zheng, Lei; Xuan, Xiaofeng

doi:10.1016/j.bios.2019.111879

Cited by 34 publications

(19 citation statements)

References 37 publications

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“…The S-protein is tested with tenfold increase from 10 -5 to 10 -1 ng/mL in 0.1×PBS solution. Here the upper-limit concentration of 10 -1 ng/mL is determined by observing the saturation phenomenon [31,32] This indicates the sensor's primary performance of output monotonicity In Fig. 1a, the linearity of the transient curves become worse after 10 s when the concentration is high.…”

Section: Resultsmentioning

confidence: 99%

Real-time Sensing of Trace Biomarkers from Viruses with a Microfluidic Immunosensor: A Case Study of SARS-CoV-2 Detection in Cold-chain Food

Qi¹,

Zhang

Cheng³

et al. 2020

Preprint

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Section: Resultsmentioning

confidence: 99%

Real-time Sensing of Trace Biomarkers from Viruses with a Microfluidic Immunosensor: A Case Study of SARS-CoV-2 Detection in Cold-chain Food

Qi¹,

Zhang

Cheng³

et al. 2020

Preprint

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“…The solution of fluorescent particles (FluoSpheres ® Carboxylate-Modified Microspheres, 1 μm, nile red fluorescent 535/575, 2% solids) was diluted 1000 times by 0.5× SSC. Even though both ACEO and ACET microflows were generated by nonuniform electric fields between electrodes, for electrodes with a thermally insulative substrate, flow patterns were fundamentally different [31,32]. While ACEO flows went from the electrode edge to its inside, ACET flows followed the direction of thermal gradients, i.e., going opposite to the ACEO directions, in this case.…”

Section: Frequency Optimizationmentioning

confidence: 89%

“…Because both were larger than the miRNA-16b tested here, the DEP effect was much more pronounced for enrichment. Thereby, it was reasonable to have a better response at 10 kHz for miRNA-16b detection due to the dominance of the ACET effect for miRNA enrichment [24,31].…”

Section: Frequency Optimizationmentioning

confidence: 99%

Rapid and Sensitive Detection of miRNA Based on AC Electrokinetic Capacitive Sensing for Point-of-Care Applications

Wan

Jiang

Huang

et al. 2021

Sensors

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A sensitive and efficient method for microRNAs (miRNAs) detection is strongly desired by clinicians and, in recent years, the search for such a method has drawn much attention. There has been significant interest in using miRNA as biomarkers for multiple diseases and conditions in clinical diagnostics. Presently, most miRNA detection methods suffer from drawbacks, e.g., low sensitivity, long assay time, expensive equipment, trained personnel, or unsuitability for point-of-care. New methodologies are needed to overcome these limitations to allow rapid, sensitive, low-cost, easy-to-use, and portable methods for miRNA detection at the point of care. In this work, to overcome these shortcomings, we integrated capacitive sensing and alternating current electrokinetic effects to detect specific miRNA-16b molecules, as a model, with the limit of detection reaching 1.0 femto molar (fM) levels. The specificity of the sensor was verified by testing miRNA-25, which has the same length as miRNA-16b. The sensor we developed demonstrated significant improvements in sensitivity, response time and cost over other miRNA detection methods, and has application potential at point-of-care.

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“…AuNPs colorimetric assay combined with aptamer SS2-55 can realize the high-throughput screening of OPs [ 71 , 72 ]. Zhang et al [ 73 ] constructed an aptamer SS2-55-modified micro-interdigitated electrode chip for quantitative detection of the four OPs. The LODs for the target OPs were 0.24–1.67 fM.…”

Section: Rapid Multi-residue Detection Methods Based On Different mentioning

confidence: 99%

Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

et al. 2020

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The excessive use or abuse of pesticides and veterinary drugs leads to residues in food, which can threaten human health. Therefore, there is an extremely urgent need for multi-analyte analysis techniques for the detection of pesticide and veterinary drug residues, which can be applied as screening techniques for food safety monitoring and detection. Recent developments related to rapid multi-residue detection methods for pesticide and veterinary drug residues are reviewed herein. Methods based on different recognition elements or the inherent characteristics of pesticides and veterinary drugs are described in detail. The preparation and application of three broadly specific recognition elements—antibodies, aptamers, and molecular imprinted polymers—are summarized. Furthermore, enzymatic inhibition-based sensors, near-infrared spectroscopy, and SERS spectroscopy based on the inherent characteristics are also discussed. The aim of this review is to provide a useful reference for the further development of rapid multi-analyte analysis of pesticide and veterinary drug residues.

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An interdigitated microelectrode based aptasensor for real-time and ultratrace detection of four organophosphorus pesticides

Cited by 34 publications

References 37 publications

Real-time Sensing of Trace Biomarkers from Viruses with a Microfluidic Immunosensor: A Case Study of SARS-CoV-2 Detection in Cold-chain Food

Real-time Sensing of Trace Biomarkers from Viruses with a Microfluidic Immunosensor: A Case Study of SARS-CoV-2 Detection in Cold-chain Food

Rapid and Sensitive Detection of miRNA Based on AC Electrokinetic Capacitive Sensing for Point-of-Care Applications

Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

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