An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice

Xenakis, James G.; Douillet, Christelle; Bell, Timothy A; Hock, Pablo; Farrington, Joseph; Liu, Tianyi; Murphy, Caroline; Saraswatula, Avani; Shaw, Ginger D; Nativio, Gustavo; Shi, Qing; Venkatratnam, Abhishek; Zou, Fei; Fry, Rebecca C.; Stýblo, Miroslav; Villena, Fernando P Pardo Manuel De

doi:10.1007/s00335-022-09957-w

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…A total of 16 studies conducted on animals used mice [ 13 , 14 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], Wistar rats [ 12 , 27 , 28 , 29 ], Sprague-Dawley rats [ 30 ], and a diversity of outbred male mice [ 31 ]. The animals were exposed to different As doses ranging from 0.20 to 800 mg/L for different periods, with the lowest exposure being 15 min and the highest being 12 months, and these studies were published between 2006 and 2022 ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among the included studies, only three [15,20,43] did not identify an association between As exposure and glycemic alterations (Table 2). A total of 16 studies conducted on animals used mice [13,14,[19][20][21][22][23][24][25][26], Wistar rats [12,[27][28][29], Sprague-Dawley rats [30], and a diversity of outbred male mice [31]. The animals were exposed to different As doses ranging from 0.20 to 800 mg/L for different periods, with the lowest exposure being 15 min and the highest being 12 months, and these studies were published between 2006 and 2022 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Epidemiological studies have reported that exposure to As may be associated with increased HOMA-IR index [ 47 ], hemoglobin A1c [ 3 , 4 ], fasting glucose level [ 12 , 31 , 41 ], insulin resistance [ 21 , 31 , 36 , 45 ], and glucose intolerance [ 13 , 21 , 23 , 30 ]. In contrast, mice (C57BL/6) exposed to iAs in drinking water (5 and 50 ppm) for 18 weeks showed no significant changes in serum glucose and insulin concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies

Rosendo,

Ferreira,

Aquino

et al. 2024

Nutrients

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Background: Arsenic (As) is a risk factor associated with glycemic alterations. However, the mechanisms of action and metabolic aspects associated with changes in glycemic profiles have not yet been completely elucidated. Therefore, in this review, we aimed to investigate the metabolic aspects of As and its mechanism of action associated with glycemic changes. Methods: We searched the PubMed (MEDLINE) and Google Scholar databases for relevant articles published in English. A combination of free text and medical subject heading keywords and search terms was used to construct search equations. The search yielded 466 articles; however, only 50 were included in the review. Results: We observed that the relationship between As exposure and glycemic alterations in humans may be associated with sex, smoking status, body mass index, age, occupation, and genetic factors. The main mechanisms of action associated with changes induced by exposure to As in the glycemic profile identified in animals are increased oxidative stress, reduced expression of glucose transporter type 4, induction of inflammatory factor expression and dysfunction of pancreatic β cells. Conclusions: Therefore, As exposure may be associated with glycemic alterations according to inter-individual differences.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies

Rosendo,

Ferreira,

Aquino

et al. 2024

Nutrients

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Metabolic Derangement by Arsenic: a Review of the Mechanisms

Bibha,

Akhigbe,

Hamed

et al. 2023

Biol Trace Elem Res

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The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice

Blanchard,

Sigmon,

Brennan

et al. 2024

Preprint

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The MiniMUGA genotyping array is a popular tool for genetic QC of laboratory mice and genotyping of samples from most types of experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of the production version of the MiniMUGA array is fixed; however, there is the opportunity to improve array’s performance and the associated report’s usefulness by leveraging thousands of samples genotyped since the initial description of MiniMUGA in 2020. Here we report our efforts to update and improve marker annotation, increase the number and the reliability of the consensus genotypes for inbred strains and increase the number of constructs that can reliably be detected with MiniMUGA. In addition, we have implemented key changes in the informatics pipeline to identify and quantify the contribution of specific genetic backgrounds to the makeup of a given sample, remove arbitrary thresholds, include the Y Chromosome and mitochondrial genome in the ideogram, and improve robust detection of the presence of commercially available substrains based on diagnostic alleles. Finally, we have made changes to the layout of the report, to simplify the interpretation and completeness of the analysis and added a table summarizing the ideogram. We believe that these changes will be of general interest to the mouse research community and will be instrumental in our goal of improving the rigor and reproducibility of mouse-based biomedical research.

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An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice

Cited by 5 publications

References 49 publications

Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies

Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies

Metabolic Derangement by Arsenic: a Review of the Mechanisms

The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice

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