An intelligent ZIF-8-gated polydopamine nanoplatform for <i>in vivo</i> cooperatively enhanced combination phototherapy

Feng, Jie; Yu, Wenjie; Xu, Zhen; Wang, Fuan

doi:10.1039/c9sc06337d

Cited by 70 publications

(51 citation statements)

References 34 publications

(45 reference statements)

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“…The characteristic peak of PQ912 shifted from 280 to 300 nm after encapsulating into ZIF‐8 on account of the coordination between PQ912 and Zn 2+ (Figure 1i). The Fourier transform infrared spectroscopy (FTIR) spectra of ZIF‐PQ‐PDA‐AUN presented one characteristic FTIR peak of AUNP‐12 (1663 cm −1 ) after loading AUNP‐12 onto the nanoplatform, which resulted from the amide I, demonstrating an efficient encapsulation of the AUNP‐12 payload [ 33 ] (Figure 1j). The loading capacity of AUNP‐12 was about 16.2 wt.%, which was assessed through calculating the loading amount by high‐performance liquid chromatography (HPLC), while the loading capacity of PQ912 was determined to be about 8.7 wt.% by UV–vis spectroscopy measurements at 280 nm (Figure S3, Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

M2‐Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

Zhao

et al. 2021

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Immune checkpoint inhibitor (ICI) therapy is considered to be a revolutionary anti-tumor strategy that may surpass other traditional therapies. Breast cancer is particularly suitable for it theoretically due to upregulation of programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) immune checkpoint pathway which exhausts the adaptive immune response mediated by T lymphocytes. However, its blockades exhibit very little effect in breast cancer, owing to the lack of T lymphocytes pre-infiltration and co-existing of intricate immune negative microenvironment including the macrophage-suppressed "Don't eat me" CD47 signal overexpression. Herein, a stimuli-responsive multifunctional nanoplatform (ZIF-PQ-PDA-AUN) is built. Its photothermal therapy can promote the infiltration of T lymphocytes in addition to ablating tumor cells and AUNP-12 and PQ912 further boost both the innate and adaptive immune reactions by cutting off PD-L1 and CD47 signals, respectively. In contrast to earlier single immunotherapy, the nanocomposites exhibit a stronger anti-tumor immune effect without obvious autoimmune side effects, promoting infiltration of T lymphocyte into the tumor site and strengthening phagocytosis of macrophages, even more exciting, significantly reversing pro-tumor M2-like tumor-associated macrophages (TAMs) to anti-tumor M1-like TAMs. The research may provide a promising strategy to develop high-efficient and low-toxic immunotherapy based on nanotechnology. therapies such as surgery, radiotherapy, and chemotherapy [3] are often of limited benefits while triggering undesirable complications. In recent years, programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors have stolen the limelight in the fight against tumors because of its elicited impressive clinical efficacy in non-small cell lung cancer, melanoma, etc. However, breast cancer is proven to be an immune "cold" tumor, characterized by the low response to immunotherapies including the PD-1/ PD-L1 inhibitors. [4] It's attributed to the insufficient T lymphocytes infiltration and the intricate immunosuppressive tendency in the tumor microenvironment (TME). [5] Of note, the emerging photothermal therapy (PTT) has been confirmed to promote the migration of immune cells into the tumors. PTT, a noninvasive therapeutic modality, is capable of thermal ablation local tumor cells by converting near-infrared light energy into heat. Intriguingly, PTT has shown an enormous potential use in cancer immunotherapy. It is a high-efficiency method for inducing T cells to eliminate cancer cells through releasing tumor neoantigen in situ. [6] What's more, heat-stressed tumor cells will also generate exosomes [7] containing antigens and a variety of chemokines, chemoattracting CD11c + DC and CD4 + /CD8 + T cells to infiltrate the tumor. [8] PTT combined with check point blockade by PD-1 or CTLA-4 antibodies was proved to reinvigorate the exhausted CD8+ T cells, thereby significantly enhancing the anti-tumor effect. [6,9] Unfortunately, the TME is ...

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Section: Methodsmentioning

confidence: 99%

M2‐Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

Zhao

et al. 2021

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“…Feng et al successfully synthesised a multifunctional zeolitic imidazolate frameworks 8 (ZIF-8)-gated PDA NP carrier for simultaneously delivering a photosensitiser and a catalase (CAT) into tumour cells [133]. The ZIF-8 gatekeeper enables the concurrent and effective delivery of these functional payloads and the successive tumour acidic pH-stimulated drug release.…”

Section: Biocompatibility Of Pda Npsmentioning

confidence: 99%

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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Biological structures have emerged through millennia of evolution, and nature has fine-tuned the material properties in order to optimise the structure-function relationship. Following this paradigm, polydopamine (PDA), which was found to be crucial for the adhesion of mussels to wet surfaces, was hence initially introduced as a coating substance to increase the chemical reactivity and surface adhesion properties. Structurally, polydopamine is very similar to melanin, which is a pigment of human skin responsible for the protection of underlying skin layers by efficiently absorbing light with potentially harmful wavelengths. Recent findings have shown the subsequent release of the energy (in the form of heat) upon light excitation, presenting it as an ideal candidate for photothermal applications. Thus, polydopamine can both be used to (i) coat nanoparticle surfaces and to (ii) form capsules and ultra-small (nano)particles/nanocomposites while retaining bulk characteristics (i.e., biocompatibility, stability under UV irradiation, heat conversion, and activity during photoacoustic imaging). Due to the aforementioned properties, polydopamine-based materials have since been tested in adhesive and in energy-related as well as in a range of medical applications such as for tumour ablation, imaging, and drug delivery. In this review, we focus upon how different forms of the material can be synthesised and the use of polydopamine in biological and biomedical applications. platform is highlighted ( Figure 1A). Then, theoretical and experimental proof of the chemical formation of polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applications are envisaged. Materials 2019, 12, x FOR PEER REVIEW 2 of 22polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applicatio...

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“…In order to overcome this obstacle a core-shell photothermal agent was designed, which could achieve tumor-specific drug administration and simultaneous hypoxia amelioration via sufficient O 2 generation from endogenous hydrogen peroxide. Illustratively, the PS methylene blue (MB) and a catalase (CAT) were simultaneously delivered into tumor cells via their encapsulation in ZIF-8-gated PDA nano-carrier [ 223 ]. The ZIF-8 shell acted as a smart gatekeeper facilitating the simultaneous and also effective delivery of the two payloads into tumor tissues, where the acidic tumor microenvironment could trigger their slow release via acidic dissolution of ZIF-8.…”

Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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An intelligent ZIF-8-gated polydopamine nanoplatform for in vivo cooperatively enhanced combination phototherapy

Abstract: The extreme complexity and heterogeneity of fatal tumors requires the development of combination phototherapy considering the limited therapeutic efficiency of conventional monomodal photodynamic therapy (PDT) or photothermal therapy (PTT).

Cited by 70 publications

References 34 publications

M2‐Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

M2‐Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

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