An integrative Tai Chi program for patients with breast cancer undergoing cancer therapy: study protocol for a randomized controlled feasibility study

Liu, Lizhou; Petrich, Simone; McLaren, Blair; Kelly, Lyndell; Baxter, G. David

doi:10.1016/j.joim.2017.12.011

Cited by 10 publications

(8 citation statements)

References 51 publications

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“…However, with the advancement and development of screening diagnosis and treatment techniques, the early diagnosis rate, surgical resection rate, and postoperative survival rate of liver cancer patients have increased significantly. In addition, cancer-related symptoms and treatment measures impair both body function and the quality of life of patients [3]. As a result, cancer rehabilitation has been increasingly considered important for the treatment and prognosis of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aerobic Exercise on Serum Metabolites in Mice with Hepatocellular Carcinoma After Surgery

et al. 2019

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Background Modern medicine has suggested exercise therapy is one of the main treatments for postoperative rehabilitation of tumors. It can influence the recovery of cancer patients by changing the body’s material metabolism and energy metabolism. However, studies on metabolic changes of exercise therapy on hepatocellular carcinoma (HCC) patients after surgery are limited. The aim of this study was to explore the effect of aerobic exercise on mice after orthotopic HCC surgery by serum metabolomics test and explore the related mechanism. Material/Methods A total of 60 C57Bl/6 mice were used to establish an orthotopic xenograft model of H22 mouse hepatoma cells. Mice were randomly divided into 6 groups and it was found that the metabolic products of the early postoperative exercise group and sedentary group mainly included L-tryptophan, citric acid, and other energy-related metabolites. Results Energy metabolites, such as succinic acid of the high-intensity exercise group were increased after surgery, whereas phospholipid metabolites, including phosphatidylethanolamine (18: 0/0: 0), were decreased. In the moderate-intensity exercise group, the change tendency was consistent, and the level of various metabolites decreased. Conclusions Thus, it is likely that aerobic exercise reduced the degree of postoperative stress responses and improved energy metabolism in mice. The underlying mechanism involves improving the tricarboxylic acid cycle, intervening in energy metabolism, reorganization caused by the tumor, reducing the abnormal increase of phospholipase activity caused by the stress of liver cancer, reducing the level of hemolytic phospholipids, thereby inhibiting mitochondrial pathway-initiated apoptosis.

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Section: Introductionmentioning

confidence: 99%

Effect of Aerobic Exercise on Serum Metabolites in Mice with Hepatocellular Carcinoma After Surgery

et al. 2019

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“…One other trial (52) was suspended (no reason provided). Six of the trials without published results were ongoing trials, and only one had exceeded their anticipated completion date [721 days over as of 22 nd January 2020 (53)]. The remaining five studies had a median of 222 (min-max: 38-648) days from the time of writing to the anticipated study completion date (as recorded in the trial registrations).…”

Section: Resultsmentioning

confidence: 99%

Outcome Reporting bias in Exercise Oncology trials (OREO): a cross-sectional study

Singh

Fairman

Christensen

et al. 2021

Preprint

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Background: Despite evidence of selective outcome reporting across multiple disciplines, this has not yet been assessed in trials studying the effects of exercise in people with cancer. Therefore, the purpose of our study was to explore prospectively registered randomised controlled trials (RCTs) in exercise oncology for evidence of selective outcome reporting. Methods: Eligible trials were RCTs that 1) investigated the effects of at least partially supervised exercise interventions in people with cancer; 2) were preregistered (i.e. registered before the first patient was recruited) on a clinical trials registry; and 3) reported results in a peer-reviewed published manuscript. We searched the PubMed database from the year of inception to September 2020 to identify eligible exercise oncology RCTs clinical trial registries. Eligible trial registrations and linked published manuscripts were compared to identify the proportion of sufficiently preregistered outcomes reported correctly in the manuscripts, and cases of outcome omission, switching, and silently introduction of non- novel outcomes. Results: We identified 31 eligible RCTs and 46 that were ineligible due to retrospective registration. Of the 405 total prespecified outcomes across the 31 eligible trials, only 6.2% were preregistered complete methodological detail. Only 16% (n=148/929) of outcomes reported in published results manuscripts were linked with sufficiently preregistered outcomes without outcome switching. We found 85 total cases of outcome switching. A high proportion (41%) of preregistered outcomes were omitted from the published results manuscripts, and many published outcomes (n=394; 42.4%) were novel outcomes that had been silently introduced (median, min-max=10, 0-50 per trial). We found no examples of preregistered efficacy outcomes that were measured, assessed, and analysed as planned. Conclusions: We found evidence suggestive of widespread selective outcome reporting and non-reporting bias (omitted preregistered outcomes, outcome switching, and silently introduced novel outcomes). The existence of such reporting discrepancies has implications for the integrity and credibility of RCTs in exercise oncology.

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“…TCC as an intervention may provide benefit to cancer survivors in these multiple areas of need based on its characteristics of combining aspects of meditation and aerobic exercise. Various protocols of the Tai Chi exercise have been created, multiple factors such as the expertise of Tai Chi practitioners, inconsistent designs of the Tai Chi programs (frequency, intensity, content, and duration), multivariant control group and biological and sociological characteristics of breast cancer greatly affect the clinical significance of the mean effect size [20]. Consequently, these clinical and methodological factors may affect the reliability of the conclusions.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer

Pan¹

2018

CMR

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Background: In the case of large heterogeneity, the data combination of randomized controlled trials will lead to the decrease of the reliability of systematic review and meta analysis, so we conducted the present study. Objectives: To explore sources of heterogeneity in studies on Tai Chi Chuan (TCC) as a complementary and alternative method for managing the overall quality of life of postoperative breast cancer patients. Methods: Randomized controlled trials were searched for in PubMed, EMBASE, Web of Science and the Cochrane Library through August 2017. The Cochrane Handbook 5.2 standards and Stata software version 10.0 were adopted for evaluating the quality of the included studies and the data was analyzed on overall quality of life of TCC. A separate univariate meta-regression analysis was performed on the study duration, sample size, cancer staging, prior breast cancer treatment, different types of TCC intervention group, different types of control group, intervention duration, mean age, and ethnicity to detect important factors leading to heterogeneity. Results: Significant heterogeneity was present in the included studies that used TCC to improve the overall quality of life of postoperative breast cancer patients from the retrieved literature (P < 0.05). The univariate meta-regression analysis indicated that the source of heterogeneity was not apparent in the analyzed factors within or between studies. Conclusions: A normative approach in studies evaluating the use of TCC for improving the overall quality of life of postoperative breast cancer patients was not sufficiently explored in the existing randomized controlled trials (RCTs). An insufficient number of RCTs in this field may be the reason that the effect size had unclear clinical significance. The existing evidence provided limited judgment on sources of heterogeneity between studies evaluating the use of TCC for improving overall quality of life in postoperative breast cancer patients.

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An integrative Tai Chi program for patients with breast cancer undergoing cancer therapy: study protocol for a randomized controlled feasibility study

Cited by 10 publications

References 51 publications

Effect of Aerobic Exercise on Serum Metabolites in Mice with Hepatocellular Carcinoma After Surgery

Effect of Aerobic Exercise on Serum Metabolites in Mice with Hepatocellular Carcinoma After Surgery

Outcome Reporting bias in Exercise Oncology trials (OREO): a cross-sectional study

Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer

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