An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth

Joe, Peter; Clemente, José C.; Piras, Enrica; Wallach, D.; Robinson‐Papp, Jessica; Boka, Emeka; Remsen, Brooke; Bonner, Mharisi; Kimhy, David; Goetz, Deborah; Hoffman, Kevin W.; Lee, Jakleen J.; Ruby, Eugene; Fendrich, Sarah; Gonen, Oded; Malaspina, Dolores

doi:10.1016/j.schres.2021.09.019

Cited by 8 publications

(3 citation statements)

References 202 publications

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“…Microbiome acts as a mediator to transmit environmental impact as immune signals to the brain [6]. A previous study transplant schizophrenia patients' gut microbiota to healthy mice induced schizophrenic symptoms in mice [7].…”

Section: The Connection Between Schizophrenia and The Microbiota Of T...mentioning

confidence: 99%

The relationship between gut microbiota and schizophrenia: Recent research and treatment application

Yang¹,

Qi²

2023

HSET

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Schizophrenia (SZC) is a common, chronic, and severe mental illness. Recent years have witnessed increased study into the link between gut microbiome and psychotic disorders, particularly schizophrenia. Focusing on inflammatory, tryptophan compounds, and BDNF concentrations, we examine the data that currently exists linking intestinal microbiota to schizophrenia and explain how the presumptive dysregulation could fit into accepted theories of the disease's pathophysiology. We looked at recent research and assessed the therapeutic possibility of modifying the intestinal microbiota with prebiotics as adjuvant therapy for schizophrenia. Overall, although the available information on microbiome changes in schizophrenia is extremely erratic and inadequate to draw any firm conclusions. There were successful attempts that decreased the risk of SCZ by interfering with the intestinal microbiota. The gut microbiota is a possible approach to the treatment of schizophrenia.

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Section: The Connection Between Schizophrenia and The Microbiota Of T...mentioning

confidence: 99%

The relationship between gut microbiota and schizophrenia: Recent research and treatment application

Yang¹,

Qi²

2023

HSET

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Section: Introductionmentioning

confidence: 99%

“…The gut microbiome is a highly promising avenue through which metabolic signaling, inflammatory pathways, environmental factors, and genetics all influence BD pathogenesis. The gut microbiome has been suggested to be involved in numerous central nervous system (CNS) disorders such as major depressive disorder (MDD) [5,6], anxiety [7–10], schizophrenia [11], and attention-deficit/hyperactivity disorder (ADHD) [12] by way of the bidirectional signaling pathway referred to as the “gut-brain-axis.” Intestinal microbiota play a prominent role in gut-brain signaling by producing metabolites such as short-chain fatty acids (SCFAs) that regulate CNS activity through interception of the vagus nerve [13–15]. As a result, gut microbiota can contribute to the regulation of the neuromodulatory and neuroinflammatory systems implicated in the pathogenesis of various psychiatric disorders [16].…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice

Bukowski-Thall,

Fellendorf,

Gorkiewicz

et al. 2023

Preprint

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Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes of depression and (hypo-) mania. The gut microbiome is a potential avenue through which metabolic signaling, inflammatory pathways, environmental factors, and genetics influence BD pathogenesis via the gut-brain axis. Fecal microbiota transplantation (FMT) is a powerful translational tool for investigating the connections between the gut microbiome and BD, and there is evidence FMT can transfer affective symptoms of BD from humans to mice. In this study, we compared the behavior, gut-brain metabolomic profiles, and inflammatory marker expression in two groups of adult female C57BL/6J mice, one receiving FMT from a human donor with BD in a mixed episode ( HAM-D = 20, YMRS = 14) and another receiving FMT from a mentally healthy weight and age-matched control donor without BD (HAM-D and YMRS = 0). Here, we demonstrate that mice receiving FMT from individuals with BD had an increased abundance of Bacteroidota and decreased abundances ofParabacteroides merdaeandAkkermansia muciniphilaassociated with altered levels of fecal metabolites, short-chain fatty acids, and related gut hormone expression relative to mice receiving control donor FMT. BD mice also exhibited differential regulation of several metabolites and inflammatory markers in the amygdala, with glycine being the most prominently affected. Furthermore, BD mice displayed increased anxiety-like behavior and decreased sociability, indicating that aspects of the behavioral phenotype of BD are transferable from humans to mice via FMT. Taken together, these findings implicate gut-brain signaling in the physiological and behavioral changes observed in our BD-FMT mouse model.

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Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial

Badrfam,

Zandifar,

Hajialigol

et al. 2024

Psychopharmacology

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An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth

Cited by 8 publications

References 202 publications

The relationship between gut microbiota and schizophrenia: Recent research and treatment application

The relationship between gut microbiota and schizophrenia: Recent research and treatment application

Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice

Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial

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