“…Ideally, the optimal physical layout of an inpatient care facility is determined given the decisions on service mix, case mix, care unit partitioning and care unit size. However, in practice, it often happens vice versa: physical characteristics of a facility constraint service mix, care unit partitioning and care unit size decisions [77,499]. Newly-built hospi-tals are preferably designed such that they support resource pooling and have modular spaces so that they are as flexible as possible with respect to care unit partitioning and dimensioning [499].…”