An Integrative Genomic Analysis of Formalin Fixed Paraffin-Embedded Archived Serous Ovarian Carcinoma Comparing Long-term and Short-term Survivors

Stålberg, Karin; Crona, Joakim; Razmara, Masoud; Taslica, Diana; Skogseid, Britt; Stålberg, Peter

doi:10.1097/igc.0000000000000721

Cited by 4 publications

(4 citation statements)

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“…The factors reported to be associated with long-term survival are: grade, stage, primary mass size tumor [24], the absence of ascites [11], normal CA125 level before platinum therapy, negative Ki-67 expression, underexpression of p53 [25], age <40 years [26], performance status (PS), tumor histology [27], and stage IIIC due to nodal involvement [28] which is consistent with the results herein. At the molecular level, patterns of gene expression and genomic instability distinguish short-and long-term survivors [29][30][31][32]. Some studies have demonstrated that BRCA mutation status is associated with improved long-term survival independently of primary platinum sensitivity in stage III-IV ovarian cancer, suggesting that underlying tumor biology contributes to disease outcome [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Long-term survival in patients with epithelial ovarian cancer following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

Saux

Decullier

Gléhen

et al. 2018

International Journal of Hyperthermia

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Objective: Despite a high response rate to first-line therapy, prognosis of epithelial ovarian carcinoma (EOC) remains poor. The objective of the present study was to evaluate the frequency of long-term survivors and to identify the prognostic factors associated with long-term survival in a French cohort of 566 patients. Methods: Patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for EOC in 13 French centers between 1991 and 2010 were included. Long-term survivors were defined as patients who survived more than 5 years after HIPEC and CRS, irrespective of relapse. Results: Seventy-eight long-term survivors were analyzed. The median follow-up was 74 months. Median age at the time of first HIPEC was 55.4 years (range [22.6-77.6]. Seven patients had advanced EOC and 71 patients had recurrent EOC (37 patients had platinum-resistant EOC and 32 had platinumsensitive disease). More than half of the long-term survivors had high-grade serous ovarian cancer (HGSOC). In univariate analysis, age 50 years (p ¼ .004), peritoneal cancer index (PCI) 8 (p ¼ .049) and CA-125 < 100 (p ¼ .02) were associated with long-term survival. There was a trend towards an association between higher CC-score and long-term survival (p ¼ .057). Conclusion: Age 50 years, PCI 8 and CA125 < 100 were associated with long-term survival in univariate analysis. There was a trend towards the significance of CC-score. Platinum-status was not associated with long-term survival.

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Section: Discussionmentioning

confidence: 99%

Long-term survival in patients with epithelial ovarian cancer following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

Saux

Decullier

Gléhen

et al. 2018

International Journal of Hyperthermia

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“…In addition to clinical and pathological characteristics, genomic stability also seems to be a hallmark of long-term survival. For example, Stalberg et al assessed genomic profiles in an integrative genetic analysis of patients with serous ovarian cancer (6). Using single nucleotide polymorphism (SNP) arrays and targeted next-generation sequencing of 26 genes, they observed an increased genomic stability, a lower proportion of somatic copy number alterations and a lower average ploidy among ovarian cancer patients with long-term survival compared to those with early cancer-specific death.…”

mentioning

confidence: 99%

What Characterizes Long-term Survivors of Recurrent Ovarian Cancer? Case Report and Review of the Literature

Hilal

Schultheis

Hartmann

et al. 2016

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“…But it is also noted that there are still long-term survivors of recurrent ovarian cancer with survival time longer than five years. Clinical features at the time of primary therapy like optimal surgical cytoreduction and platinum-sensitivity [24], and genomic features like a lower proportion of somatic copy number alterations and a lower average ploidy [25] have been associated with long survival. Yet, there is still much unknown about the biomarkers associated with short/long survival in women with ovarian cancer.…”

Section: Ovarian Cancer-associated Gene Networkmentioning

confidence: 99%

MSIGNET: A Bayesian Approach for Disease-associated Gene Network Identification

Chen¹,

Xuan²

2020

OBM Genetics

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The analysis of gene networks and signalling pathways plays a key role in understanding gene functions, i.e., their effects on the development of a particular disease. Yet, for many heterogeneous diseases, the number of known disease-associated genes is limited. Identifying disease-associated genes is still an open challenge. To understand the functions of genes associated with a disease, we develop a Metropolis-Hastings sampling based SIGnificant NETwork (MSIGNET) identification approach. MSIGNET integrates disease gene expression data and human protein-protein interactions in a Bayesian network, and identifies interactions of genes specifically expressed under the disease condition. We applied MSIGNET to simulation and benchmark data. Results demonstrated its superior performance over conventional network identification tools on disease-associated gene network identification when multiple local gene modules existed. To learn genes and functional signalling pathways associated with ovarian cancer recurrence, we identified a gene network using TCGA ovarian cancer gene expression data and further validated results using an independent gene expression data set. Genes in the identified network were significantly enriched with cellular processes relevant to ovarian cancer development, and as

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An Integrative Genomic Analysis of Formalin Fixed Paraffin-Embedded Archived Serous Ovarian Carcinoma Comparing Long-term and Short-term Survivors

Abstract: We validated both previous genomic findings in ovarian cancer and the proposed association between increased genomic instability and better survival. These results exemplify that analysis of genomic biomarkers is feasible on archived FFPE tissue.

Cited by 4 publications

References 24 publications

Long-term survival in patients with epithelial ovarian cancer following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

Long-term survival in patients with epithelial ovarian cancer following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

What Characterizes Long-term Survivors of Recurrent Ovarian Cancer? Case Report and Review of the Literature

MSIGNET: A Bayesian Approach for Disease-associated Gene Network Identification

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