An integrative GC–MS and LC–MS metabolomics platform determination of the metabolite profile of Bombax ceiba L. root, and in silico & in vitro evaluation of its antibacterial & antidiabetic activities

Insights into the Origin and Therapeutic Implications of Benzopyran and Its Derivatives

“…Some compounds have the first report on the presence of lathodoratin, cedrene, 4H‐1‐benzopyran‐4‐one,8‐[{dimethylamino} methyl]‐7‐methoxy‐3‐methyl‐2‐phenyl, asiatic acid, and (E)‐2,4,4′‐trihydroxylchalcone in B. ceiba roots. Methanol extract confirmed noteworthy antibacterial activity against Staphylococcus aureus (MTCC96) (MIC: 100 μg/mL) comparison toward antibiotic ampicillin (MIC: 250 μg/mL) as well as the highest α‐amylase inhibition (IC 50 =26.91 μg/mL) and α‐glucosidase inhibition (IC 50 =21.21 μg/mL) effects, molecular docking and some compounds having a very high docking score [149] . Sulfonamide derivatives of pyrrolidine and piperidine (anti‐diabetic agents) for the treatment of anticancer and antidiabetic agents [164] .…”

“…Methanol extract confirmed noteworthy antibacterial activity against Staphylococcus aureus (MTCC96) (MIC: 100 μg/mL) comparison toward antibiotic ampicillin (MIC: 250 μg/mL) as well as the highest α-amylase inhibition (IC 50 = 26.91 μg/mL) and α-glucosidase inhibition (IC 50 = 21.21 μg/mL) effects, molecular docking and some compounds having a very high docking score. [149] Sulfonamide derivatives of pyrrolidine and piperidine (anti-diabetic agents) for the treatment of anticancer and antidiabetic agents. [164] The dipeptidyl peptidase-4 (DPP-4) inhibitors compound has been synthesized for insulin resistance and chronic hyperglycemia.…”