An Integrative Approach to Investigate the Mode of Action of (−)-Dendroparishiol in Bacterial Meningitis: Computer-Aided Estimation of Biological Activity and Network Pharmacology

Limcharoen, Thanchanok; Wasana, Peththa Wadu Dasuni; Hasriadi,; Angsuwattana, Pornpoom; Muangnoi, Chawanphat; Warinhomhoun, Sakan; Ongtanasup, Tassanee; Sritularak, Boonchoo; Vajragupta, Opa; Rojsitthisak, Pornchai; Towiwat, Pasarapa

doi:10.3390/ijms24098072

Cited by 1 publication

(1 citation statement)

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“… This is an open-source image: (a) kyphoscoliosis deformity, (b) X-ray of the entire spine in a standing position before surgery, (c) X-ray of the entire spine while bending, (d) three-dimensional reconstruction of the complete spinal computed tomography scan, (e) simulation of vertebral column resection osteotomy, and (f) after surgery, an X-ray of the entire spine in a standing position reveals significant improvement in the deformity [ 20 ]. …”

Section: Reviewmentioning

confidence: 99%

Risk Factors in Administering Spinal Anesthesia: A Comprehensive Review

Doelakeh,

Chandak

2023

Cureus

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Numerous advantages, including a quick start and consistent anesthesia, are provided by spinal anesthesia, a method often utilized in contemporary medicine for various surgical operations. However, it has some hazards, just like any medical procedure. With an emphasis on identifying and assessing the risk factors associated with administering spinal anesthesia, the review analyzes published literature and clinical investigations carried out in the field of anesthesia. Various key factors, including technique-related procedural and patient-related aspects, can influence the effectiveness of spinal anesthesia. Among these factors are age, sex, body mass index, concurrent conditions (such as cardiovascular disease, diabetes, and respiratory problems), pre-existing neurological issues, allergies, and a history of adverse responses to anesthesia drugs. Additionally, the chance of problems might be increased by physical abnormalities or malformations in the spinal canal and vertebral column. The safety and effectiveness of spinal anesthesia depend significantly on procedural factors, such as the type and dosage of anesthesia agents administered and the patient's position and alignment maintained during the entire surgical procedure and the injection rate. Increased risks can also be caused by inadequate monitoring and a slow response to unfavorable circumstances. Risk factors related to the technique include the expertise and competency of the anesthesiologist or medical professional carrying out the procedure. Inadequate post-procedure monitoring, inadvertent dural puncture, and improper needle placement might lead to complications during or after the spinal anesthesia administration. This review emphasizes the need for a complete preoperative assessment, suitable patient selection, and rigorous procedural planning to reduce the likelihood of problems during the administration of spinal anesthesia. It also emphasizes the significance of ongoing monitoring and timely management of adverse events to guarantee patient safety and the best results. Healthcare professionals may put preventative measures in place and follow best practices to limit possible consequences efficiently by recognizing the risk factors associated with spinal anesthesia. This review helps encourage safer anesthesia practices and improve patient care as medical knowledge and technology advance. However, further study and evidence-based recommendations are required to enhance patient outcomes and risk assessment.

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Section: Reviewmentioning

confidence: 99%