An integrative analysis to predict the active compounds and explore polypharmacological mechanisms of Orthosiphon stamineus Benth.

Orthosiphon stamineus Benth, a potential herb in treatment of gout: A mini opinion and call for further research

“…Interestingly, after taking solution of herb extract about 30 days, levels of uric acid and symptoms of warmth, redness, and excruciating pain are well controlled. Orthosiphol Z, orthosiphol Y, 14-deoxo-14-Oacetylorthosiphol Y, vomifoliol, caffeic acid, rosmarinic acid, eupatorin, and sinensetin are core compounds serving as the most representative pharmacological active compounds 10 . Interestingly, rosmarinic acid and sinensetin, were identified as diuretic agents.…”

Anti-cervical cancer mechanism of bioactive compounds from Alangium platanifolium based on the ‘compound-target-disease’ network

“…Compounds in AP were pharmacokinetically screened using SwissADME [ 18 ]. SwissADME is widely for evaluating the druggability of small molecule compounds in natural products [ 19 , 20 ]. The screening criteria for potential active compounds were: (1) Gastrointestinal (GI) absorption was ‘High’; (2) two or more of the five types of medicinal properties (Lipinski, Ghose, Veber, Egan, Muegge) results were ‘yes’.…”