An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells

Zhao, Yu; Cai, Huihui; Ding, Xiaoling; Zhou, Xiaorong

doi:10.1007/s10142-023-01056-6

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…↑ medullary thyroid carcinoma, pancreatic cancer, breast cancer, colorectal cancer, rectal cancer, melanoma [99,107,118,119] ↓ serous ovarian carcinoma [120] negative correlation with OS and DFS in early breast cancer [95] positive correlation with RFS in colorectal cancer [99] positive correlation with OS in lung, pancreatic cancer, gastric, and clear cell renal cell cancer [121] hypermethylation predicts a negative survival factor in B-cell lymphoma [95] DUSP5…”

Section: Regulation Of Tam Functions By Duspsmentioning

confidence: 99%

Dual-Specificity Phosphatases in Regulation of Tumor-Associated Macrophage Activity

Patysheva,

Prostakishina,

Budnitskaya

et al. 2023

IJMS

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The regulation of protein kinases by dephosphorylation is a key mechanism that defines the activity of immune cells. A balanced process of the phosphorylation/dephosphorylation of key protein kinases by dual-specificity phosphatases is required for the realization of the antitumor immune response. The family of dual-specificity phosphatases is represented by several isoforms found in both resting and activated macrophages. The main substrate of dual-specificity phosphatases are three components of mitogen-activated kinase signaling cascades: the extracellular signal-regulated kinase ERK1/2, p38, and Janus kinase family. The results of the study of model tumor-associated macrophages supported the assumption of the crucial role of dual-specificity phosphatases in the formation and determination of the outcome of the immune response against tumor cells through the selective suppression of mitogen-activated kinase signaling cascades. Since mitogen-activated kinases mostly activate the production of pro-inflammatory mediators and the antitumor function of macrophages, the excess activity of dual-specificity phosphatases suppresses the ability of tumor-associated macrophages to activate the antitumor immune response. Nowadays, the fundamental research in tumor immunology is focused on the search for novel molecular targets to activate the antitumor immune response. However, to date, dual-specificity phosphatases received limited discussion as key targets of the immune system to activate the antitumor immune response. This review discusses the importance of dual-specificity phosphatases as key regulators of the tumor-associated macrophage function.

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