An Integration Strategy to Develop Dual-State Luminophores with Tunable Spectra, Large Stokes Shift, and Activatable Fluorescence for High-Contrast Imaging

Liu, Yongchao; Teng, Lili; Xu, Cheng‐Yan; Ren, Tian‐Bing; Xu, Shuai; Lou, Xiaofeng; Yuan, Lin; Zhang, Xiaobing

doi:10.31635/ccschem.021.202100935

Cited by 30 publications

(23 citation statements)

References 33 publications

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“…This optimized geometric structure data revealed that NIR-3 possesses a relatively more coplanarity than NIR-1 and NIR-2. Furthermore, the biggest oscillator strength was consistent with the enhanced fluorescence intensity of NIR-3 ( Figure S6 ) 46 . As depicted in Figure S7 , for both NIR-1, NIR-2 and NIR-3, the highest occupied molecular orbital (HOMO) mainly localizes on the skeleton of molecules, whereas the lowest unoccupied molecular orbital (LUMO) mostly distributes on the electron-rich donor moiety.…”

Section: Resultssupporting

confidence: 72%

A novel afterglow nanoreporter for monitoring cancer therapy

Liao¹,

Wang²,

Li³

et al. 2022

Theranostics

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Rationale: Immunogenic cell death (ICD)-associated immunogenicity evoked through reactive oxygen species (ROS) is an efficient way to fight against the immune-dysfunctional microenvironment, so as to provoke potent anti-tumor immunity. However, the unknown ROS dose during cancer therapies may induce adverse immune responses (e.g., insufficient ICD, toxicity toward normal tissues or immune system). Methods: Herein, we developed a pyrido pyrazine - thiophene based semiconducting polymer as novel near-infrared (NIR) organic afterglow nanoparticles for the real-time visualization of self-generated ROS, during photodynamic-mediated immunogenic cell death. Specifically, we introduced the strong “acceptor” (pyrido pyrazine) into thiophene based semiconducting polymer to redshift emission wavelength, and further modulate the “donor” to afford more afterglow reaction sites and reducing ΔEst, so as to enhance luminescence intensity. Results: The semiconducting polymer-based afterglow nanoparticles exhibit strong afterglow emission with longer-wavelength emission (> 800 nm), compared with the reported organic afterglow nanoparticles (e.g., MEHPPV, PFODBT or Chlorin, < 690 nm), which endows this afterglow nanoparticles with a greatly improvement of signal to noise ratio. Moreover, the photodynamic effect of this afterglow nanoparticles can induce immunogenic cell death of cancer cells and further cause immune responses in mice. Conclusions: The NIR afterglow signal presents a good relationship with ROS generation, immunogenic cell death and outcome of treatment. Therefore, it was able to provide a non-invasive tool for predicting the degree of ICD that occurs during ROS-mediated cancer therapy and may contribute to precise immunotherapy.

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Section: Resultssupporting

confidence: 72%

A novel afterglow nanoreporter for monitoring cancer therapy

Liao¹,

Wang²,

Li³

et al. 2022

Theranostics

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“…β-Galactosidase is an overexpressed glycoside hydrolase enzyme in ovarian cancers. − Pu et al designed and synthesized a βGal-activatable macrotheranostic probe CyGal-P that specifically turns on its PA through specifically cleaving the d -galactose-caged moiety of the probe CyGal. CyGal-P is composed of a d -galactose-caged NIR hemicyanine dye (CyOH) that is connected with a long poly(ethylene glycol) (PEG) chain (Figure a) .…”

Section: Activatable Pa Probes For Molecular Detectionmentioning

confidence: 99%

Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

et al. 2022

Self Cite

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Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular imaging due to its high imaging depth and resolution. To endow PA imaging with the ability for real-time molecular visualization and precise biomedical diagnosis, numerous activatable molecular PA probes which can specifically alter their PA intensities upon reacting with the targets or biological events of interest have been developed. This review highlights the recent developments of activatable PA probes for precise biomedical applications including molecular detection of the biotargets and imaging of the biological events. First, the generation mechanism of PA signals will be given, followed by a brief introduction to contrast agents used for PA probe design. Then we will particularly summarize the general design principles for the alteration of PA signals and activatable strategies for developing precise PA probes. Furthermore, we will give a detailed discussion of activatable PA probes in molecular detection and biomedical imaging applications in living systems. At last, the current challenges and outlooks of future PA probes will be discussed. We hope that this review will stimulate new ideas to explore the potentials of activatable PA probes for precise biomedical applications in the future.

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“…Fluorophores with tunable emission properties have attracted increasing interest because of their applications in organic light-emitting diodes, 1–3 bioimaging, 4–6 fluorescent sensors, 7–10 and photovoltaic cells. 11,12 Two approaches have been adopted to develop fluorescent materials with tunable emission properties (especially those exhibiting white-emission): (1) synthesis of hybrid dye molecules with different color emissions and (2) rational design of single molecules by the covalent or non-covalent bonding of multiple fluorescent groups with different luminous colors.…”

Section: Introductionmentioning

confidence: 99%