An integrated systematic approach for investigating microcurrent electrical nerve stimulation (MENS) efficacy in STZ-induced diabetes mellitus

Luo, Yiliao; Huang, Sing‐Han; Pathak, Nikhil; Chuang, Yi Hsuan; Yang, Jinn-Moon

doi:10.1016/j.lfs.2021.119650

Cited by 5 publications

(3 citation statements)

References 67 publications

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“…Recent reports indicate also some other unexpected effects of nerve stimulation. For example, Guyot et al (2019) [39] described that pancreatic nerve stimulation inhibits the onset of autoimmune diabetes in mice and Luo et al (2021) [40] presented evidence from a mouse model that non-invasive microcurrent electrical nerve stimulation may improve glycemic control comparable to pharmacologic anti-diabetic com-pounds. Taken together, there are promising data indicate that electroceuticals may be helpful in the treatment of diabetes and associated problems.…”

Section: Why Diabetes?mentioning

confidence: 99%

The Potential of Electrical Stimulation and Smart Textiles for Patients with Diabetes Mellitus

et al. 2022

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Diabetes mellitus is one of the most frequent diseases in the general population. Electrical stimulation is a treatment modality based on the transmission of electrical pulses into the body that has been widely used for improving wound healing and for managing acute and chronic pain. Here, we discuss recent advancements in electroceuticals and haptic/smart devices for quality of life and present in which patients and how electrical stimulation may prove to be useful for the treatment of diabetes-related complications.

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Section: Why Diabetes?mentioning

confidence: 99%

The Potential of Electrical Stimulation and Smart Textiles for Patients with Diabetes Mellitus

et al. 2022

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“…Besides, a novel physiological effect of magnetostatic and electrostatic fields has been demonstrated for the long-term, noninvasive management of type 2 diabetes in mouse models 8 . Recently, a study in STZ-induced diabetes mellitus in mouse models showed that microcurrent electrical nerve stimulation exhibited effects similar to anti-diabetic drugs, through the peroxisome proliferator-activated receptor (PPAR), bile secretion, and insulin signaling pathways 9 . In a pre-clinical setting, we have proven that our TENS device significantly improved glucose parameters in a diabetic mouse model 10 , as indicated by fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA 1c ) ( Appendix in Supplementary Material).…”

Section: Introductionmentioning

confidence: 99%

A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes

Lü

et al. 2023

Sci Rep

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Transcutaneous electrical nerve stimulator (TENS) has been demonstrated to be beneficial in glycemic control in animal models, but its application in humans has not been well studied. We randomly assigned 160 patients with type 2 diabetes on oral antidiabetic drugs 1:1 to the TENS study device (n = 81) and placebo (n = 79). 147 (92%) randomized participants (mean [SD] age 59 [10] years, 92 men [58%], mean [SD] baseline HbA1c level 8.1% [0.6%]) completed the trial. At week 20, HbA1c decreased from 8.1% to 7.9% in the TENS group (− 0.2% [95% CI − 0.4% to − 0.1%]) and from 8.1% to 7.8% in the placebo group (− 0.3% [95% CI − 0.5% to − 0.2%]) (P = 0.821). Glycemic variability, measured as mean amplitude of glycemic excursion (MAGE) at week 20 were significantly different in the TENS group vs. the placebo group (66 mg/dL [95% CI 58, 73] vs. 79 mg/dL [95% CI 72, 87]) (P = 0.009). Our study provides the clinical evidence for the first time in humans that TENS does not demonstrate a statistically significant HbA1c reduction. However, it is a safe complementary therapy to improve MAGE in patients with type 2 diabetes.

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“…Besides, a novel physiological effect of magnetostatic and electrostatic elds has been demonstrated for the long-term, noninvasive management of type 2 diabetes in mouse models 12 . Recently, a study in STZinduced diabetes mellitus in mouse models showed that microcurrent electrical nerve stimulation exhibited effects similar to anti-diabetic drugs, through the peroxisome proliferator-activated receptor (PPAR), bile secretion, and insulin signaling pathways 13 . In a pre-clinical setting, we have proven that our TENS device signi cantly improved glucose parameters in a diabetic mouse model 14 , as indicated by fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA 1c ).…”

mentioning

confidence: 99%

A Randomized Trial on the Effect of Transcutaneous Electrical Nerve Stimulator on Glycemic Control in Patients with Type 2 Diabetes

Lü

et al. 2022

Preprint

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Transcutaneous electrical nerve stimulator (TENS) has been demonstrated to be beneficial in glycemic control in animal models, but its application in humans has not been well studied. We randomly assigned 160 patients with type 2 diabetes on oral antidiabetic drugs 1:1 to the TENS study device (n=81) and placebo (n=79). 147 (92%) randomized participants (mean [SD] age 59 [10] years, 92 men [58%], mean [SD] baseline HbA1c level 8.1% [0.6%]) completed the trial. At week 20, HbA1c decreased from 8.1% to 7.9% in the TENS group (-0.2% [95% CI: -0.4% to -0.1%]) and from 8.1% to 7.8% in the placebo group (-0.3% [95% CI: -0.5% to -0.2%]) (P = 0.821). Mean amplitude of glycemic excursion (MAGE) at week 20 were significantly different (66 mg/dL [95% CI: 58, 73] vs. 79 mg/dL [95% CI: 72, 87]) (P = 0.009). Besides, we noticed that hypoglycemia accounted for 6/54 (11%) of total adverse events and 14/46 (30%) in the TENS vs. the placebo groups. Our study provides the clinical evidence for the first time in humans that TENS does not demonstrate a statistically significant HbA1c reduction. However, it is a safe complementary therapy to improve MAGE in patients with type 2 diabetes.

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An integrated systematic approach for investigating microcurrent electrical nerve stimulation (MENS) efficacy in STZ-induced diabetes mellitus

Cited by 5 publications

References 67 publications

The Potential of Electrical Stimulation and Smart Textiles for Patients with Diabetes Mellitus

The Potential of Electrical Stimulation and Smart Textiles for Patients with Diabetes Mellitus

A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes

A Randomized Trial on the Effect of Transcutaneous Electrical Nerve Stimulator on Glycemic Control in Patients with Type 2 Diabetes

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