2014
DOI: 10.1289/ehp.1307049
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An Integrated Risk Function for Estimating the Global Burden of Disease Attributable to Ambient Fine Particulate Matter Exposure

Abstract: Background: Estimating the burden of disease attributable to long-term exposure to fine particulate matter (PM2.5) in ambient air requires knowledge of both the shape and magnitude of the relative risk (RR) function. However, adequate direct evidence to identify the shape of the mortality RR functions at the high ambient concentrations observed in many places in the world is lacking.Objective: We developed RR functions over the entire global exposure range for causes of mortality in adults: ischemic heart dise… Show more

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Cited by 1,506 publications
(1,322 citation statements)
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“…The relative risk (RR) of four causes of death, chronic obstructive pulmonary disease, ischemic heart disease, lung cancer, and stroke, when compared with annual incident rate has been assessed separately. Such risks are described by a log-linear relationship with the corresponding PM 2.5 concentration level (Burnett et al, 2014). The basic form of RR formulas is provided as follows:…”
Section: Health Impact Assessment (Hia)mentioning
confidence: 99%
“…The relative risk (RR) of four causes of death, chronic obstructive pulmonary disease, ischemic heart disease, lung cancer, and stroke, when compared with annual incident rate has been assessed separately. Such risks are described by a log-linear relationship with the corresponding PM 2.5 concentration level (Burnett et al, 2014). The basic form of RR formulas is provided as follows:…”
Section: Health Impact Assessment (Hia)mentioning
confidence: 99%
“…We also examine the impact of using a low-concentration threshold. We apply a threshold of 5.8 µg m −3 (suggested by Burnett et al, 2014 which is derived from Lim et al, 2012) to annual mean PM 2.5 concentrations. Differences in AF estimates associated with long-term exposure to populationweighted PM 2.5 concentrations range from −4.8 to +2.1 % (as compared to −4.7 to +2.8 % above when no threshold is applied).…”
Section: Attributable Fraction Associated With Long-termmentioning
confidence: 99%
“…We evaluated the associations of SBP and DBP with exposure to PM 2.5 mass, BC, and WSOM. We express the results as the changes in SBP or DBP associated with a 1-ln(μg/m 3 ) increase in pollutant exposure using one and two-pollutant multivariate mixed-effects models because there was evidence of a nonlinear association (21,22).…”
Section: Significancementioning
confidence: 99%