An integrated platform for small-animal hyperthermia investigations under ultra-high-field MRI guidance

Curto, Sergio; Faridi, Pegah; Shrestha, Tej B.; Pyle, Marla; Maurmann, Leila; Troyer, Deryl L.; Bossmann, Stefan H.; Prakash, Punit

doi:10.1080/02656736.2017.1339126

Cited by 28 publications

(36 citation statements)

References 38 publications

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“…Although several animal-MRI devices have been developed, clinical MRI systems are superior to those in terms of various factors, such as stability of image acquisition and diversity of imaging sequences. Moreover, since the available internal space for experiments in animal MRI systems is significantly small, performing dynamic experiments is difficult (Curto et al 2018;Maramraju et al 2011). Although a clinical MRI system is more convenient in that aspect, acquiring a significant amount of signal from a small object is difficult because the system is built for humans (Figure 3A).…”

Section: Discussionmentioning

confidence: 99%

Development of a dynamic imaging method for gravitropism in pea sprouts using clinical magnetic resonance imaging system

Nakai

Azuma

Nakaso

et al. 2020

Plant Biotechnology

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Although magnetic resonance imaging (MRI) is a useful technique, only a few studies have investigated the dynamic behavior of small subjects using MRI owing to constraints such as experimental space and signal amount. In this study, to acquire high-resolution continuous three-dimensional gravitropism data of pea (Pisum sativum) sprouts, we developed a small-bore MRI signal receiver coil that can be used in a clinical MRI and adjusted the imaging sequence. It was expected that such an arrangement would improve signal sensitivity and improve the signal-to-noise ratio (SNR) of the acquired image. All MRI experiments were performed using a 3.0-T clinical MRI scanner. An SNR comparison using an agarose gel phantom to confirm the improved performance of the small-bore receiver coil and an imaging experiment of pea sprouts exhibiting gravitropism were performed. The SNRs of the images acquired with a standard 32-channel head coil and the new small-bore receiver coil were 5.23±0.90 and 57.75±12.53, respectively. The SNR of the images recorded using the new coil was approximately 11-fold higher than that of the standard coil. In addition, when the accuracy of MR imaging that captures the movement of pea sprout was verified, the difference in position information from the optical image was found to be small and could be used for measurements. These results of this study enable the application of a clinical MRI system for dynamic plant MRI. We believe that this study is a significant first step in the development of plant MRI technique.

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Section: Discussionmentioning

confidence: 99%

Development of a dynamic imaging method for gravitropism in pea sprouts using clinical magnetic resonance imaging system

Nakai

Azuma

Nakaso

et al. 2020

Plant Biotechnology

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“…From an engineering point of view, the proposed approach requires a more complex, bulky and expensive system than a standard focused MWH system, which must include a measurement apparatus for the acquisition of the differential signal and another one for the generation of the PMF. However, concerning this latter, it should not represent a further burden if one takes into account that the current trend is to integrate microwave hyperthermia with MRI for the continuous and not invasive monitoring of the temperature rise during the treatment [38].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Nanoparticle-Guided Blind Focusing in Microwave Hyperthermia of Neck Tumors

Bellizzi

Bucci

2019

IEEE Access

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This paper aims to assess a recently proposed approach for microwave hyperthermia, exploiting magnetic nanoparticles as modulable contrast agents in order to blindly focus on the tumor the electric field radiated by an antenna array. The approach has been improved and numerically assessed in the realistic and clinically relevant case of the treatment of neck tumors. To this end, a realistic system, whose layout is inspired to an existing one, currently under clinical testing, has been considered. The Zubal phantom has been exploited to carry out the simulations. The numerical results show that the proposed blind focusing approach works properly even in realistic and complex situations like the one considered in this paper. Moreover, the results compare very well with those obtained through not-blind focusing approaches, based on the knowledge of geometry, positioning, and electric properties of the irradiated tissues. The robustness of approach against the measurement noise has been also analyzed, in order to identify the requirements that the measurement apparatuses must satisfy and the minimum amount of magnetic nanoparticles to be administered to the patient in order to make the approach feasible. The performed thermal analysis confirmed the ability of the approach to selectively heat the tumor. The proposed approach could be a valid alternative to achieve an effective field focusing without any a priori information on the electric and geometrical properties of the anatomical region to be treated. Moreover, it could be employed in combination with magnetic hyperthermia to improve the effectiveness of the therapy.INDEX TERMS Antenna array, blind focusing, magnetic nanoparticles, microwave hyperthermia, neck tumors.

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“…Simulations and experiments in tissue mimicking phantoms demonstrated the feasibility of heating 21-982 mm 3 targets to temperature rises of T increase > 3 C at radial distances up to $6 mm from the applicator, with 8-12 W input power. DT max between MR thermometry and fiber-optic temperatures was 0.6 C. In vivo experiments demonstrated the feasibility of delivering HT to implanted tumors in two experimental mice in combination with PRFS based MRT [69]. $4 C and $11 C temperature increase were achieved with 20 W microwave exposure for 5 min and 15 min, respectively.…”

Section: Preclinical (Animal) Setupsmentioning

confidence: 92%

“…-The coaxial applicator incorporates a 3.5 mm directional microwave antenna operating at 2.45 GHz designed for small animal investigations inside the 30 mm bore of the 14 T ultrahigh field MRI scanner [69]. Simulations and experiments in tissue mimicking phantoms demonstrated the feasibility of heating 21-982 mm 3 targets to temperature rises of T increase > 3 C at radial distances up to $6 mm from the applicator, with 8-12 W input power.…”

Section: Preclinical (Animal) Setupsmentioning

confidence: 99%

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia

Adibzadeh

Sümser

Curto

et al. 2020

International Journal of Hyperthermia

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Clinical trials have demonstrated the therapeutic benefits of adding radiofrequency (RF) hyperthermia (HT) as an adjuvant to radio-and chemotherapy. However, maximum utilization of these benefits is hampered by the current inability to maintain the temperature within the desired range. RF HT treatment quality is usually monitored by invasive temperature sensors, which provide limited data sampling and are prone to infection risks. Magnetic resonance (MR) temperature imaging has been developed to overcome these hurdles by allowing noninvasive 3D temperature monitoring in the target and normal tissues. To exploit this feature, several approaches for inserting the RF heating devices into the MR scanner have been proposed over the years. In this review, we summarize the status quo in MR-guided RF HT devices and analyze trends in these hybrid hardware configurations. In addition, we discuss the various approaches, extract best practices and identify gaps regarding the experimental validation procedures for MR-RF HT, aimed at converging to a common standard in this process.

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An integrated platform for small-animal hyperthermia investigations under ultra-high-field MRI guidance

Abstract: A platform for small-animal hyperthermia investigations under ultra-high-field MR thermometry was developed and applied to heating subcutaneous tumours in vivo.

Cited by 28 publications

References 38 publications

Development of a dynamic imaging method for gravitropism in pea sprouts using clinical magnetic resonance imaging system

Development of a dynamic imaging method for gravitropism in pea sprouts using clinical magnetic resonance imaging system

Magnetic Nanoparticle-Guided Blind Focusing in Microwave Hyperthermia of Neck Tumors

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia

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